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Practical Compass of Single-Cell RNA-Seq Analysis
Practical Compass of Single-Cell RNA-Seq Analysis
This review paper provides step-by-step instructions on the fundamental process, from handling fastq datasets to illustrat...
Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis
Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis
We primarily aim to review differences in bone mineral density (BMD) for osteoporosis among different racial/ethnic groups...
Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation
Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation
To summarize what is known about the deleterious effect of hip fracture on muscle mass and strength as well as the scienti...
Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting
Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting
This review aims to explore the potential of biomimetic hydrogels as an alternative to bone cement in vertebral body stent...
Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies
Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies
GWAS, as a largely correlational analysis, requires in vitro or in vivo validation. Zebrafish (Danio rerio) have many adva...
Weight-bearing Guidelines for Common Geriatric Upper and Lower Extremity Fractures
Weight-bearing Guidelines for Common Geriatric Upper and Lower Extremity Fractures
The purpose of this review paper is to summarize current weight-bearing guidelines for common geriatric fractures, around ...
Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging
Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging
Summarize the recent literature that investigates how advanced medical imaging has contributed to our understanding of ske...
Bone Material Properties in Bone Diseases Affecting Children
Bone Material Properties in Bone Diseases Affecting Children
Metabolic and genetic bone disorders affect not only bone mass but often also the bone material, including degree of miner...
Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease
Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease
As the importance of osteocytes for bone mineral homeostasis is increasingly recognized, there is growing interest in oste...
Correction: Bringing Mechanical Context to Image-Based Measurements of Bone Integrity
Correction: Bringing Mechanical Context to Image-Based Measurements of Bone Integrity
Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, 105 Administration Place, Saskatoon, SK, S...
The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting
The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting
Here, we discuss the origin of chondrocytes, their destiny, and their plasticity in relationship to bone growth, articulat...
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
Metformin is an anti-glycemic agent, which is widely prescribed to diabetes patients. Although its alleged role on bone st...
Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
The integration of data from multiple genomic assays from humans and non-human model organisms is an effective approach to...
Novel Insights into Osteoclast Energy Metabolism
Novel Insights into Osteoclast Energy Metabolism
Osteoclasts are crucial for the dynamic remodeling of bone as they resorb old and damaged bone, making space for new bone....
Inflammatory Processes Affecting Bone Health and Repair
Inflammatory Processes Affecting Bone Health and Repair
The purpose of this article is to review the current understanding of inflammatory processes on bone, including direct imp...
Osteocyte Mechanotransduction in Orthodontic Tooth Movement
Osteocyte Mechanotransduction in Orthodontic Tooth Movement
Orthodontic tooth movement is characterized by periodontal tissue responses to mechanical loading, leading to clinically r...
Early Life Management of Osteogenesis Imperfecta
Early Life Management of Osteogenesis Imperfecta
This review aims to provide a review of the multidisciplinary management of infants with osteogenesis imperfecta (OI) duri...
The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy
The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy
To summarise the evidence regarding the effects of gender-affirming hormone therapy (GAHT) on bone health in transgender p...
Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence
Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence
The purpose of this review is to discuss the role of macrophages in the regulation of skeletal health with age, particular...
Osteocytes and Primary Cilia
Osteocytes and Primary Cilia
The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays i...
From Inflammation to Resolution: Specialized Pro-resolving Mediators in Posttraumatic Osteoarthritis
From Inflammation to Resolution: Specialized Pro-resolving Mediators in Posttraumatic Osteoarthritis
To provide a comprehensive overview of the inflammatory response following anterior cruciate ligament (ACL) injury and to ...
Racial and Ethnic Differences in Studies of the Gut Microbiome and Osteoporosis
Racial and Ethnic Differences in Studies of the Gut Microbiome and Osteoporosis
The purpose of this review is to summarize the scientific evidence published in the past 5 years examining the epidemiolog...
Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications
Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications
This review examines the diverse functional relationships that exist between the peripheral nervous system (PNS) and bone,...
Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
The purpose of this review is to summarize the recently published scientific literature regarding the effects of mitochond...
Osteoporosis and Fracture Risk among Older US Asian Adults
Osteoporosis and Fracture Risk among Older US Asian Adults
This review summarizes the current knowledge regarding osteoporosis and fracture among older US Asian adults. Asian adults...
Fracture Risk in Patients with Hypoparathyroidism
Fracture Risk in Patients with Hypoparathyroidism
To summarize the recently published scientific evidence on fracture risk in hypoparathyroidism. Hypoparathyroidism is char...
Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments
Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments
The study aims to provide updated information on the genetic factors associated with the diagnoses ‘Diffuse Idiopath...
Sclerostin and Cardiovascular Disease
Sclerostin and Cardiovascular Disease
The role of wnt signalling in atherogenesis raises the possibility that the wnt inhibitor, sclerostin, provides a natural ...
Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases
Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases
Runt-related transcription factors (RUNX) play critical roles in skeletal development, metabolism, and diseases. In mammal...
Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg
Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg
Recently, there has been an increasing number of studies on the crosstalk between the bone and the bone marrow and how it ...
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