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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
Melatonin, the ‘hormone of darkness’ is a neuronal hormone secreted by the pineal gland and other extra pineal...
Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility
Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that involves functional and structural defects in...
The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhib...
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans...
Mutation of TRPML1 Channel and Pathogenesis of Neurodegeneration in Haimeria
Mutation of TRPML1 Channel and Pathogenesis of Neurodegeneration in Haimeria
Neurodegenerative diseases, a group of debilitating disorders, have garnered increasing attention due to their escalating ...
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a v...
Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia
Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia
Neurons and microglia are sensitive to cerebral microcirculation and their responses play a crucial part in the pathologic...
TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats
TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats
In this study, we investigated whether transient receptor melastatin 7 (TRPM7), known as a non-selective cation channel, i...
Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Exosomes are small extracellular vesicles with a complex lipid-bilayer surface and 30–150 nm diameter. Thes...
Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Kearns-Sayre syndrome (KSS) is a rare multisystem mitochondrial disorder. It is caused by mitochondrial DNA (mtDNA) rearra...
Histone 3 Trimethylation Patterns are Associated with Resilience or Stress Susceptibility in a Rat Model of Major Depression Disorder
Histone 3 Trimethylation Patterns are Associated with Resilience or Stress Susceptibility in a Rat Model of Major Depression Disorder
Major Depressive Disorder (MDD) is a severe and multifactorial psychiatric condition. Evidence has shown that environmenta...
Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus
Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus
Motopsin, a serine protease encoded by PRSS12, is secreted by neuronal cells into the synaptic clefts in an activity-depen...
Proteomic-miRNA Biomics Profile Reveals 2D Cultures of Human iPSC-Derived Neural Progenitor Cells More Sensitive than 3D Spheroid System Against the Experimental Exposure to Arsenic
Proteomic-miRNA Biomics Profile Reveals 2D Cultures of Human iPSC-Derived Neural Progenitor Cells More Sensitive than 3D Spheroid System Against the Experimental Exposure to Arsenic
The iPSC-derived 3D models are considered to be a connective link between 2D culture and in vivo studies. However, the sen...
Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases
Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases
As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural ligands. However, its biological ...
Methylene Blue Pretreatment Protects Against Repeated Neonatal Isoflurane Exposure-Induced Brain Injury and Memory Loss
Methylene Blue Pretreatment Protects Against Repeated Neonatal Isoflurane Exposure-Induced Brain Injury and Memory Loss
Perioperative neurocognitive impairment (PND) is a common medical complication in the postoperative period. General anesth...
Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers
Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers
Cancer is a serious public health concern worldwide, and nervous system (NS) cancers are among the most life-threatening m...
Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples
Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples
Amyotrophic lateral sclerosis (ALS) is a paralytic disease that damages the brain and spinal cord motor neurons. Several c...
Integrated Bulk and Single-Cell RNA-Sequencing Reveals the Effects of Circadian Rhythm Disruption on the Metabolic Reprogramming of CD4+ T Cells in Alzheimer’s Disease
Integrated Bulk and Single-Cell RNA-Sequencing Reveals the Effects of Circadian Rhythm Disruption on the Metabolic Reprogramming of CD4+ T Cells in Alzheimer’s Disease
Although growing evidence suggests close correlations between Alzheimer’s disease (AD) and circadian rhythm disrupti...
Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG
Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG
Correction to: Molecular NeurobiologyThe original version of this article unfortunate...
Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions
Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions
Alzheimer’s disease (AD), a multifactorial disease, is characterized by the accumulation of neurofibrillary tangles ...
Extracellular Purine Metabolism—Potential Target in Multiple Sclerosis
Extracellular Purine Metabolism—Potential Target in Multiple Sclerosis
The purinergic signaling system comprises a complex network of extracellular purines and purine-metabolizing ectoenzymes, ...
Oxidative Stress and Migraine
Oxidative Stress and Migraine
The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, acco...
Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease
Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease
Reactive astrocytes play an important role in the development of Alzheimer’s disease (AD). Here, we aimed to investi...
High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
We present a panel of central nervous system (CNS) complications associated with coronavirus disease 2019 (COVID-19) and t...
Research Advances in Neuroblast Migration in Traumatic Brain Injury
Research Advances in Neuroblast Migration in Traumatic Brain Injury
Neuroblasts were first derived from the adult mammalian brains in the 1990s by Reynolds et al. Since then, persistent neur...
LPAR6 Participates in Neuropathic Pain by Mediating Astrocyte Cells via ROCK2/NF-κB Signal Pathway
LPAR6 Participates in Neuropathic Pain by Mediating Astrocyte Cells via ROCK2/NF-κB Signal Pathway
Neuropathic pain (NPP) is a common type of chronic pain. Glial cells, including astrocytes (AS), are believed to play an i...
AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment
AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment
Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are...
Acute Administration of HIV-1 Tat Protein Drives Glutamatergic Alterations in a Rodent Model of HIV-Associated Neurocognitive Disorders
Acute Administration of HIV-1 Tat Protein Drives Glutamatergic Alterations in a Rodent Model of HIV-Associated Neurocognitive Disorders
HIV-1-associated neurocognitive disorders (HAND) are a major comorbidity of HIV-1 infection, marked by impairment of execu...
Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology
Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology
Potassium voltage-gated channel subfamily a member 2 (Kv1.2, encoded by KCNA2) is highly expressed in the central and peri...
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway
Glaucoma, as an ischemia-reperfusion (I/R) injury disease, leading irreversible blindness through the loss of retinal gang...
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