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Promotion of nerve regeneration and motor function recovery in SCI rats using LOCAS-iPSCs-NSCs
Promotion of nerve regeneration and motor function recovery in SCI rats using LOCAS-iPSCs-NSCs
Spinal cord injury (SCI) is a severe traumatic spinal condition with a poor prognosis. In this study, a scaffold called li...
The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo
The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo
Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and compromises the viability of transplanted human bone mar...
Current advances in understanding endometrial epithelial cell biology and therapeutic applications for intrauterine adhesion
Current advances in understanding endometrial epithelial cell biology and therapeutic applications for intrauterine adhesion
The human endometrium is a highly regenerative tissue capable of undergoing scarless repair during the menstruation and po...
Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cor...
Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunity
Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunity
The human induced pluripotent stem cells (hiPSCs) can generate all the cells composing the human body, theoretically. Ther...
SPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
SPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
Nowadays, companion and working dogs hold significant social and economic importance. Dry eye, also known as dry keratocon...
Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes
Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes
Inherited retinal dystrophies (IRD) are one of the main causes of incurable blindness worldwide. IRD are caused by mutatio...
Autophagy modulation effect on homotypic transfer of intracellular components via tunneling nanotubes in mesenchymal stem cells
Autophagy modulation effect on homotypic transfer of intracellular components via tunneling nanotubes in mesenchymal stem cells
Recent studies have proved the role of autophagy in mesenchymal stem cell (MSCs) function and regenerative properties. How...
Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral ...
Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice
Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice
Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, th...
Evaluation of the efficacy of mesenchymal stem cells derived conditioned medium in the treatment of striae distensae: a double blind randomized clinical trial
Evaluation of the efficacy of mesenchymal stem cells derived conditioned medium in the treatment of striae distensae: a double blind randomized clinical trial
Striae distensae is a disfiguring atrophic skin condition that impairs the body’s aesthetic image. Despite the varie...
Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production
Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production
Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory ...
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with ...
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. Ho...
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomod...
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified...
The effect of TLR3 priming conditions on MSC immunosuppressive properties
The effect of TLR3 priming conditions on MSC immunosuppressive properties
Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy....
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed ...
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have sho...
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible ...
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization....
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable econo...
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for i...
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease mod...
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal and multi-directional differentiation potential and p...
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new appr...
The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response
The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response
Assisted reproduction faces a significant obstacle in the form of poor ovarian response (POR) to controlled ovarian stimul...
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
In regenerative medicine, especially skin tissue engineering, the focus is on enhancing the quality of wound healing. Also...
Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury
Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury
Acute compartment syndrome (ACS) is one of the most common complications of musculoskeletal injury, leading to the necrosi...
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