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Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Our Kaplan–Meier analysis reveals that gastric cancer patients with high androgen receptor (AR) expression demonstra...
Positive association between anti- IgG antibody titers and atrophic gastritis in a Latvian cohort
Positive association between anti- IgG antibody titers and atrophic gastritis in a Latvian cohort
Although H. pylori is the most important risk factor for gastric cancer, the role of anti-H. pylori antibody titers in gas...
Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data
Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data
Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recen...
YAP as a therapeutic target to reverse trastuzumab resistance
YAP as a therapeutic target to reverse trastuzumab resistance
Trastuzumab resistance in HER2-positive cancers remains a significant clinical challenge with limited therapeutic options....
The oncogenic role of hypomethylated in gastric carcinoma: a focus on cell survival and stemness
The oncogenic role of hypomethylated in gastric carcinoma: a focus on cell survival and stemness
Although genome-wide promoter CpG island hypermethylation of Epstein–Barr virus-associated gastric carcinoma (EBV GC...
Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors
Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors
Boron neutron capture therapy selectively delivers the boron isotope 10B to tumors, where neutron irradiation induces a nu...
Efficacy of nodal dissection for locoregional gastric neuroendocrine carcinoma: a multicenter retrospective observational study
Efficacy of nodal dissection for locoregional gastric neuroendocrine carcinoma: a multicenter retrospective observational study
Gastric neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy for which no standard treatment has been establ...
Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
In 2021, anamorelin, a ghrelin receptor agonist, was approved in Japan for cancer cachexia in select cancers, including ga...
Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results
Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results
Nivolumab plus chemotherapy demonstrated clinically significant improvement in quality-adjusted survival versus chemothera...
An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study
An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study
Nivolumab plus chemotherapy has shown efficacy in clinical trials for advanced or recurrent gastric cancer (GC). However, ...
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study
Excessive surgical stress induces inflammatory cytokine release, negatively impacting prognosis in patients with malignanc...
Resveratrol targets mitochondrial USP36–SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression
Resveratrol targets mitochondrial USP36–SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression
Gastric cancer is an aggressive malignancy with high metastatic potential, limiting effective treatments. Resveratrol, a n...
Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis
Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis
Peritoneal metastasis (PM) is a major challenge in advanced gastric cancer (GC) with poor prognosis. Normothermic intraper...
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma
Perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is the standard of care for locally advanced oes...
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication
Aberrant DNA methylation persists in the gastric mucosa after Helicobacter pylori (H. pylori) eradication and may contribu...
Serum TFF2 as a more reliable biomarker for gastric cancer and early gastric cancer: a cross-sectional population-based study
Serum TFF2 as a more reliable biomarker for gastric cancer and early gastric cancer: a cross-sectional population-based study
TFF2 is a promising yet underexplored biomarker for gastric cancer. We aimed to investigate the relationship between serum...
Assessing efficacy of anti-glypican-1 antibody–drug conjugate as potential therapeutic approach for gastric cancer
Assessing efficacy of anti-glypican-1 antibody–drug conjugate as potential therapeutic approach for gastric cancer
Despite significant advancements in cancer treatment, gastric cancer (GC) continues to have a high incidence and mortality...
Clinical impact of primary and secondary mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors
Clinical impact of primary and secondary mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are commonly driven by primary mutations in KIT or PDGFRA. Imatinib is the first-l...
Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer
Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer
Lipolysis-stimulated lipoprotein receptor (LSR), a lipid receptor, is associated with cancer progression. However, detaile...
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer
Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate targeting HER2-positive gastric cancer or gastroesophag...
Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach
Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach
Hepatoid adenocarcinoma of the stomach (HAS), a subtype of gastric cancer (GC), includes multiple tumor components, such a...
Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01)
Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01)
There is a paucity of confirmatory randomized controlled trials (RCTs) comparing the effectiveness of totally laparoscopic...
Advantages of adjuvant chemotherapy using S-1 following minimally invasive gastrectomy for gastric cancer versus open surgery: a propensity score-matched analysis
Advantages of adjuvant chemotherapy using S-1 following minimally invasive gastrectomy for gastric cancer versus open surgery: a propensity score-matched analysis
It is essential to ensure optimal adherence to adjuvant chemotherapy regimens following gastric cancer surgery. However, t...
Short-term outcomes of a phase II trial of perioperative capecitabine plus oxaliplatin therapy for advanced gastric cancer with extensive lymph node metastases (OGSG1701)
Short-term outcomes of a phase II trial of perioperative capecitabine plus oxaliplatin therapy for advanced gastric cancer with extensive lymph node metastases (OGSG1701)
The prognosis of advanced gastric cancer (GC) with extensive lymph node (LN) metastasis treated with surgery alone remains...
Decorin as a key marker of desmoplastic cancer-associated fibroblasts mediating first-line immune checkpoint blockade resistance in metastatic gastric cancer
Decorin as a key marker of desmoplastic cancer-associated fibroblasts mediating first-line immune checkpoint blockade resistance in metastatic gastric cancer
Gastric cancer (GC) remains a significant cause of cancer-related mortality worldwide. Despite the transformative impact o...
Predictors of tolerability for postoperative adjuvant S1 plus docetaxel chemotherapy for gastric cancer: a multicenter retrospective study
Predictors of tolerability for postoperative adjuvant S1 plus docetaxel chemotherapy for gastric cancer: a multicenter retrospective study
Adjuvant docetaxel plus S1 (DS) chemotherapy after gastrectomy with D2 lymph node dissection is the standard treatment for...
Survival outcomes of patients with gastric cancer treated with first-line nivolumab plus chemotherapy based on claudin 18.2 expression
Survival outcomes of patients with gastric cancer treated with first-line nivolumab plus chemotherapy based on claudin 18.2 expression
Claudin 18.2 has emerged as a viable therapeutic target in gastric cancer; however, its clinical relevance in the context ...
Predicting chemotherapy responsiveness in gastric cancer through machine learning analysis of genome, immune, and neutrophil signatures
Predicting chemotherapy responsiveness in gastric cancer through machine learning analysis of genome, immune, and neutrophil signatures
Gastric cancer is a major oncological challenge, ranking highly among causes of cancer-related mortality worldwide. This s...
Novel affibody molecules targeting the AXL extracellular structural domain for molecular imaging and targeted therapy of gastric cancer
Novel affibody molecules targeting the AXL extracellular structural domain for molecular imaging and targeted therapy of gastric cancer
Gastric cancer (GC) has a poor prognosis and high mortality because it is often diagnosed at an advanced stage. Targeted t...
YAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axis
YAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axis
Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized b...
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