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From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
Cholestasis is characterized by hepatic accumulation of bile acids. Clinical manifestation of cholestasis only occurs in a...
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation
The urinary mercapturic acids N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-...
Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy
Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy
Valproic acid (VPA) is a primary medication for epilepsy, yet its hepatotoxicity consistently raises concerns among indivi...
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Six novel brominated bis-pyridinium oximes were designed and synthesized to increase their nucleophilicity and reactivatio...
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Diagnostic and prognostic ROC curves based on the validated obtained hub genes. A–C Diagnostic ROC curves for CDKN2A, NRAS...
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years....
In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids
In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids
2-Benzylbenzimidazole ‘nitazene’ opioids are presenting a growing threat to public health. Although various ni...
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Early brain development depends on adequate transport of thyroid hormones (THs) from the maternal circulation to the fetus...
Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice
Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice
Per- and polyfluoroalkyl substances (PFAS) such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) ...
A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
Okadaic acid (OA), a prevalent marine biotoxin found in shellfish, is known for causing acute gastrointestinal symptoms. D...
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity
The development of inhaled drugs for respiratory diseases is frequently impacted by lung pathology in non-clinical safety ...
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions
Marine toxins produced by marine organisms threaten human health and impose a heavy public health burden on coastal countr...
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
The objective of the present study was to review the molecular mechanisms of the adverse effects of environmental pollutan...
Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols
Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols
Many people convicted for drunken driving suffer from an alcohol use disorder and some traffic offenders consume denatured...
Rapid quantitative high-throughput mouse embryoid body model for embryotoxicity assessment
Rapid quantitative high-throughput mouse embryoid body model for embryotoxicity assessment
Individuals are exposed to a wide arrays of hazardous chemicals on a daily basis through various routes, many of which hav...
Predictive biomarkers for embryotoxicity: a machine learning approach to mitigating multicollinearity in RNA-Seq
Predictive biomarkers for embryotoxicity: a machine learning approach to mitigating multicollinearity in RNA-Seq
Multicollinearity, characterized by significant co-expression patterns among genes, often occurs in high-throughput expres...
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo models of lipopolysaccharide (LPS)-induced pulmonary injury, quercetin-3-glucuronide (Q3G) has been p...
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C (EXCC), a marine coral-derived compound, exhibits an antiproliferation effect on bladder cancer cells. The ...
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and unde...
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Marine biotoxins are a heterogenous group of natural toxins, which are able to trigger different types of toxicological re...
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Since the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemic...
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Cytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive meta...
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Grouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source su...
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Consumption of herbal products containing pyrrolizidine alkaloids (PAs) is one of the major causes for hepatic sinusoidal ...
Thresholds of adversity for endocrine disrupting substances: a conceptual case study
Thresholds of adversity for endocrine disrupting substances: a conceptual case study
For endocrine disrupting chemicals (EDC) the existence of “safe exposure levels”, that is exposure levels that...
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors
The endocrine system functions by interactions between ligands and receptors. Ligands exhibit potency for binding to and i...
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo
Rifampicin is a strong inducer of cytochrome P450 (CYP3A4) and P-glycoprotein (P-gp/ABCB1), leading to profound drug–...
Targeting gut microbiota for immunotherapy of diseases
Targeting gut microbiota for immunotherapy of diseases
With advances in next-generation sequencing technology, there is growing evidence that the gut microbiome plays a key role...
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Physiologically based kinetic (PBK) modelling offers a mechanistic basis for predicting the pharmaco-/toxicokinetics of co...
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs
Cultivation of industrial low-Δ9-tetrahydrocannabinol (Δ9-THC) hemp has created an oversupply of cannabidiol (CB...
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