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In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo models of lipopolysaccharide (LPS)-induced pulmonary injury, quercetin-3-glucuronide (Q3G) has been p...
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C (EXCC), a marine coral-derived compound, exhibits an antiproliferation effect on bladder cancer cells. The ...
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and unde...
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Marine biotoxins are a heterogenous group of natural toxins, which are able to trigger different types of toxicological re...
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Since the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemic...
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Cytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive meta...
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes
Grouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source su...
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Consumption of herbal products containing pyrrolizidine alkaloids (PAs) is one of the major causes for hepatic sinusoidal ...
Thresholds of adversity for endocrine disrupting substances: a conceptual case study
Thresholds of adversity for endocrine disrupting substances: a conceptual case study
For endocrine disrupting chemicals (EDC) the existence of “safe exposure levels”, that is exposure levels that...
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors
The endocrine system functions by interactions between ligands and receptors. Ligands exhibit potency for binding to and i...
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo
Rifampicin is a strong inducer of cytochrome P450 (CYP3A4) and P-glycoprotein (P-gp/ABCB1), leading to profound drug–...
Targeting gut microbiota for immunotherapy of diseases
Targeting gut microbiota for immunotherapy of diseases
With advances in next-generation sequencing technology, there is growing evidence that the gut microbiome plays a key role...
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Physiologically based kinetic (PBK) modelling offers a mechanistic basis for predicting the pharmaco-/toxicokinetics of co...
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs
Cultivation of industrial low-Δ9-tetrahydrocannabinol (Δ9-THC) hemp has created an oversupply of cannabidiol (CB...
Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study
Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study
The type of experimental model for the in vitro testing of drug formulations efficiency represents an important tool in ca...
The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns
The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns
The phenylethylamine, 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’), is the prototypical example of an e...
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures
Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication f...
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells
Cannabidivarin (CBDV) and cannabigerol (CBG) are minor phytocannabinoids from Cannabis sativa, whose health benefits have ...
The role of cellular senescence in neurodegenerative diseases
The role of cellular senescence in neurodegenerative diseases
Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkins...
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Triclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; an...
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relativ...
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful blooms (CyanoHABs) pose a global ecological problem, and their lipopolysaccharides (LPS) are among ...
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
Nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylc...
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRE...
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Hazardous properties of a large number of esters of 4-hydroxybenzoic acid (parabens) have been proposed by ECHA to be asse...
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Brand P, Beilmann V, Thomas K et al (2019) The effects of exposure time on systemic inflammation in subjects with exposure...
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Sudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in ch...
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Endothelial cells (ECs), found in the innermost layer of blood vessels, are crucial for maintaining the structure and func...
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Aflatoxin B1 (AFB1) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compo...
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