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In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic ...
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
The tumorigenic dose 50 (TD50) is a widely used measure of carcinogenic potency which has historically been used to determ...
Re-thinking the link between exposure to mercury and blood pressure
Re-thinking the link between exposure to mercury and blood pressure
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant c...
Elucidating the Phase I metabolism of psilocin in vitro
Elucidating the Phase I metabolism of psilocin in vitro
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps rema...
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances...
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical r...
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
The potential risk of chemicals to the human eye is assessed by adopted test guidelines (TGs) for regulatory purposes to e...
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.cig vapi...
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious a...
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlo...
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relativ...
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Little is known about the impact of environmental pollution on thyroid function in the non-occupationally exposed populati...
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Femtosecond lasers represent a novel tool for tattoo removal as sources that can be operated at high power, potentially le...
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic a...
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exposomics is a field that studies environmental exposures and their impact on human health. The MRM-IDA-EPI method, which...
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity
Given the lack of accurate diagnostic methods of acetaminophen (APAP)-induced acute liver failure (ALF), the search for ne...
A physiologically based pharmacokinetic (PBPK) model describing the kinetics of a commercial mixture α-, β-, and γ-hexabromocyclododecane exposure in mice
A physiologically based pharmacokinetic (PBPK) model describing the kinetics of a commercial mixture α-, β-, and γ-hexabromocyclododecane exposure in mice
Hexabromocyclododecane (HBCD) is a brominated flame retardant, that is added, but not chemically bonded, to consumer produ...
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
Cholestasis is characterized by hepatic accumulation of bile acids. Clinical manifestation of cholestasis only occurs in a...
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation
The urinary mercapturic acids N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-...
Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy
Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy
Valproic acid (VPA) is a primary medication for epilepsy, yet its hepatotoxicity consistently raises concerns among indivi...
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Six novel brominated bis-pyridinium oximes were designed and synthesized to increase their nucleophilicity and reactivatio...
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Diagnostic and prognostic ROC curves based on the validated obtained hub genes. A–C Diagnostic ROC curves for CDKN2A, NRAS...
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years....
In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids
In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids
2-Benzylbenzimidazole ‘nitazene’ opioids are presenting a growing threat to public health. Although various ni...
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4
Early brain development depends on adequate transport of thyroid hormones (THs) from the maternal circulation to the fetus...
Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice
Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice
Per- and polyfluoroalkyl substances (PFAS) such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) ...
A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
Okadaic acid (OA), a prevalent marine biotoxin found in shellfish, is known for causing acute gastrointestinal symptoms. D...
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity
The development of inhaled drugs for respiratory diseases is frequently impacted by lung pathology in non-clinical safety ...
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions
Marine toxins produced by marine organisms threaten human health and impose a heavy public health burden on coastal countr...
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
The objective of the present study was to review the molecular mechanisms of the adverse effects of environmental pollutan...
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