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Three-dimensional saturated C(sp3)-rich bioisosteres for benzene
Three-dimensional saturated C(sp3)-rich bioisosteres for benzene
Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are frequently associated with poor R...
Monitoring a planetary resource under threat
Monitoring a planetary resource under threat
Understanding our water supplies is vital for our health and wellbeing. While traditional water quality analyses require a...
Solvent effects in anion recognition
Solvent effects in anion recognition
Anion recognition is pertinent to a range of environmental, medicinal and industrial applications. Recent progress in the ...
Tying the knot with lysine
Tying the knot with lysine
Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs ...
Robust scientific advisory mechanisms future-proof disarmament treaties
Robust scientific advisory mechanisms future-proof disarmament treaties
The Chemical Weapons Convention has a unique Scientific Advisory Board that ensures it keeps pace with science, and its im...
Triplet–triplet annihilation photon upconversion-mediated photochemical reactions
Triplet–triplet annihilation photon upconversion-mediated photochemical reactions
Photon upconversion is a method for harnessing high-energy excited states from low-energy photons. Such photons, particula...
Electrochemical hydrogenation and oxidation of organic species involving water
Electrochemical hydrogenation and oxidation of organic species involving water
Fossil fuel-driven thermochemical hydrogenation and oxidation using high-pressure H2 and O2 are still popular but energy-i...
Boosting band structure
Boosting band structure
Typically thought of as inert and non-participating atoms, noble gasses adsorbed onto freshly cleaved single crystal surfa...
Tailor-made glycans
Tailor-made glycans
A highly chemoselective method for the insertion of carbohydrates into existing oligosaccharides has been developed. The r...
Non-symmetric stapling of native peptides
Non-symmetric stapling of native peptides
Stapling has emerged as a powerful technique in peptide chemistry. It enables precise control over peptide conformation le...
An industrial take on developing and deploying carbon capture at scale
An industrial take on developing and deploying carbon capture at scale
To write this article, Jennifer Rudd asked managers and vice-presidents working in carbon capture and carbon dioxide remov...
The forgotten D of DEI
To mark the United Nations International Day of Persons with Disabilities we have launched a collection on chemists with d...
Phosphorescence resonance energy transfer from purely organic supramolecular assembly
Phosphorescence resonance energy transfer from purely organic supramolecular assembly
Phosphorescence energy transfer systems have been applied in encryption, biomedical imaging and chemical sensing. These sy...
Synthetically encoded complementary oligomers
Synthetically encoded complementary oligomers
Creating the next generation of advanced materials will require controlling molecular architecture to a degree typically a...
If it moves but shouldn’t
If it moves but shouldn’t
A new class of adhesive is reported where the two-component glue adheres via electrostatic interactions. The glue works ef...
Neurodiverse scientists in the workplace
Neurodiverse scientists in the workplace
The culture of scientific workplaces can cause neurodiverse scientists to face challenges. However, employing inclusive st...
Technology solutions to support blind students in the chemistry laboratory
Technology solutions to support blind students in the chemistry laboratory
For blind and low vision chemists to participate independently in the chemistry laboratory we must employ principles of un...
The experiment is the limit
The experiment is the limit
Free energy calculations have great potential to accelerate drug discovery projects by predicting relative protein–l...
Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics
Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics
More than a century old, magnesium Grignard reagents remain essential to the toolbox of organic chemists. Although similar...
Towards accessible science laboratories in Japan
Towards accessible science laboratories in Japan
The participation of people with disabilities in higher education in STEM fields in Japan is significantly lower than the ...
The cycle that sculpted evolution
A review of Transformer: The Deep Chemistry of Life and Death, where Nick Lane explores the Krebs cycle, a metabolic pathw...
Halogen chemistry of solid electrolytes in all-solid-state batteries
Halogen chemistry of solid electrolytes in all-solid-state batteries
All-solid-state batteries (ASSBs) using solid-state electrolytes, replacing flammable liquid electrolytes, are considered ...
On the origins of the conflict between Rosalind Franklin and Maurice Wilkins
Why was the relationship between Rosalind Franklin and Maurice Wilkins so fraught? A great deal has been written on the co...
Carbon on the move
Carbon on the move
In the interstellar medium, complex organic molecules are believed to form on icy dust grains in dark molecular clouds. Re...
Advances in heterogeneous single-cluster catalysis
Advances in heterogeneous single-cluster catalysis
Heterogeneous single-cluster catalysts (SCCs) comprising atomically precise and isolated metal clusters stabilized on appr...
Publisher Correction: Omniphobic liquid-like surfaces
Authors and AffiliationsSchool of Materials Science and Engineering, Key Laboratory for Polymer Composite & Functional...
Applications of macrocycle-based solid-state host–guest chemistry
Applications of macrocycle-based solid-state host–guest chemistry
Macrocyclic molecules have been used in various fields owing to their guest binding properties. Macrocycle-based host̵...
Remote autonomous titration
Remote autonomous titration
Michael DeGrandpre explains the development and workings of a submersible autonomous moored instrument for alkalinity meas...
Electrochemical cell for neutron scattering
Electrochemical cell for neutron scattering
Emily Draper explains how to design and build electrochemical equipment for neutron scattering experiments with simple, at...
Strategic application of C–H oxidation in natural product total synthesis
Strategic application of C–H oxidation in natural product total synthesis
The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural product synthesis and has alter...
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