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Si-Ni-San ameliorates cholestatic liver injury by favoring P. goldsteinii colonization
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Bioactive constituents and acute toxicity of Blighia sapida capsule extracts using wistar rats
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Qian Yang Yu Yin Granule prevents hypertensive cardiac remodeling by inhibiting NLRP3 inflammasome activation via Nrf2
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Bailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice
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Transcriptomics analysis reveals the effect of Pulsatilla decoction butanol extract on endoplasmic reticulum and peroxisome function of Candida albicans in hyphal state
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Chaihu Guizhi Decoction prevents cognitive, memory impairments and sensorimotor gating deficit induced by N-methyl-d-aspartate receptor antibody in mice
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Shuanghuanglian volatile oil exerts antipyretic, anti-inflammatory, and antibacterial synergistic effects through multiple pathways
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Periostracum Cicadae exhibits immunosuppressive effects on dendritic cells and contact hypersensitivity responses
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Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury
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Wenjing decoction: Mechanism in the treatment of dysmenorrhea with blood stasis syndrome through network pharmacology and experimental verification
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Anemarrhena asphodeloides Bunge total saponins lower lipid via modulating MAOA activity to enhance defense mechanisms in mice and C. elegans
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ZiBu PiYin recipe regulates central and peripheral Aβ metabolism and improves diabetes-associated cognitive decline in ZDF rats
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Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis
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Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway
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Systematic pharmacology and experimental validation to elucidate the inflammation-associated mechanism of Huanglian Wendan (HLWD) decoction in the treatment of MAFLD associated with atherosclerosis
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Mechanism of Biqi capsules in the treatment of gout based on network pharmacology and experimental verification
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Elucidation of the mechanism of the Yinhua Miyanling Tablet against urinary tract infection based on a combined strategy of network pharmacology, multi-omics and molecular biology
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Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure
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Quercus dentata Thunb. leaves extract inhibits CaOx crystallization and ameliorates ethylene glycol-induced CaOx kidney stones via the OPN/CD44 and NLRP3 pathways
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Efficacy and mechanism of Schisandra chinensis active component Gomisin A on diabetic skin wound healing: network pharmacology and in vivo experimental validation
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Investigating the effects of rare ginsenosides on hyperuricemia and associated sperm damage via nontargeted metabolomics and gut microbiota
Investigating the effects of rare ginsenosides on hyperuricemia and associated sperm damage via nontargeted metabolomics and gut microbiota
Hyperuricemia is a metabolic disease caused by a purine metabolism disorder or insufficient excretion of uric acid, affect...
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD
As the most prevalent liver disease globally, nonalcoholic fatty liver disease (NAFLD) encompasses a diverse range of path...
The extract of buds of Chrysanthemum morifolium ramat alleviated UVB-induced skin photoaging by regulating MAPK and Nrf2/ARE pathways
The extract of buds of Chrysanthemum morifolium ramat alleviated UVB-induced skin photoaging by regulating MAPK and Nrf2/ARE pathways
The exogenous factors of skin aging are mainly photoaging caused by ultraviolet radiation (UVR)(Krutmann et al., 2021). UV...
Alkaloids from Siparuna (Siparunaceae) are predicted as the inhibitors of proteolysis and plasma coagulation caused by snake venom and potentially counteract phospholipase A2 activity of Bothrops jararaca
Alkaloids from Siparuna (Siparunaceae) are predicted as the inhibitors of proteolysis and plasma coagulation caused by snake venom and potentially counteract phospholipase A2 activity of Bothrops jararaca
Snakebite envenomation (SBE) is an important public health challenge worldwide, being included in the list of neglected tr...
Long-term oral administration of Kelisha capsule does not cause hepatorenal toxicity in rats
Long-term oral administration of Kelisha capsule does not cause hepatorenal toxicity in rats
Aristolochic acids (AAs) mainly exist in plants of the Aristolochia species and Asarum belonging to the Aristolochiaceae f...
Treating ischemic stroke by improving vascular structure and promoting angiogenesis using Taohong Siwu Decoction: An integrative pharmacology strategy
Treating ischemic stroke by improving vascular structure and promoting angiogenesis using Taohong Siwu Decoction: An integrative pharmacology strategy
Ischemic stroke (IS), the leading cause of death and long-term disability in humans, imposes a substantial burden on the g...
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway
Postmenopausal osteoporosis (PMOP), as a major type of primary osteoporosis, inflicts harm on more than 50% of postmenopau...
Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: Involvement of arginine metabolism pathway
Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: Involvement of arginine metabolism pathway
Pulmonary fibrosis (PF) is a chronic progressive lung disease characterized by the impaired gas transfer, restricted venti...
Ganlu formula ethyl acetate extract (GLEE) blocked the development of experimental arthritis by inhibiting NLRP3 activation and reducing M1 type macrophage polarization
Ganlu formula ethyl acetate extract (GLEE) blocked the development of experimental arthritis by inhibiting NLRP3 activation and reducing M1 type macrophage polarization
Rheumatoid arthritis (RA) is one of the most prevalent systemic chronic autoimmune diseases worldwide, affecting approxima...
Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway
Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway
Millingtonia hortensis L.F. (Bignoniaceae), commonly referred to as the tree jasmine or Indian cork tree, is indigenous to...
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