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Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
In this study, an antimicrobial protein (AMP) from the epidermis of catfish (Clarias batrachus) was purified and character...
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
In this comprehensive investigation, we conducted a rigorous analysis of antimicrobial peptides (AMPs) within two venomous...
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Diabetes mellitus (DM) is a chronic endocrine disorder with lifelong implications. The prevalence of this condition is ste...
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Eupolyphaga sinensis Walker (ESW), an animal drug in traditional Chinese medicine, has been used clinically for thousands ...
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
The peptide melittin is a promising possibility for cancer treatment. The present research evaluated the anticancer impact...
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Endotoxin, also identified as lipopolysaccharide (LPS), is considered the pathogenic factor of septic shock triggered by G...
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties enco...
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptides, as therapeutic agents, can mimic the actions of molecules involved in inflammatory disorders. Antimicrobial pept...
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
Human tankyrase-1 is an important regulator of poly(ADP-ribosyl)ation (PARylation) of Wnt/β-catenin signaling and has...
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Kyotorphin (KTP) dipeptide (l-Tyrosine-l-Arginine) and their derivatives possess a multitude of functions, qualifying them...
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Over the last three decades, treatment of stroke and acute myocardial infarction (AMI) has been improved, but it has stagn...
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
Viral infections are continually emerging with new characteristics and the potential to cause outbreaks or pandemics. Ther...
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
Dental caries is a prevalent and costly disease throughout the world. Streptococcus mutans is widely recognized as one of ...
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Snake venom metalloproteinases (SVMPs) are enzymatic proteins found in snake venom and are known for their diverse biologi...
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, an inhibitor of voltage-gated sodium and potassium channels, is derived from the venom of the spider Chilobrachys ...
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Imidazole peptides possess multiple functions, including antioxidant effects, although their biological activities are lar...
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Gross morphology of knee joint surfaces; femoral condyles (F) and tibial plateaus (T). Arrowheads indicate the MIA-induced...
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Antimicrobial peptides (AMPs) are promising candidates for the development of new drugs. However, thorough studies on the ...
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Biofilm formation empowers microorganisms to withstand clearance mechanisms produced by host and synthetic sources. Biofil...
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers....
Cytotoxic Activity of A New Isoform l-Amino Acid Oxidase (Balt-LAAO-II) From Bothrops alternatus (Urutu) Snake Venom in Human Leukemic HL60 Cells
Cytotoxic Activity of A New Isoform l-Amino Acid Oxidase (Balt-LAAO-II) From Bothrops alternatus (Urutu) Snake Venom in Human Leukemic HL60 Cells
In this study, we describe the isolation of a new isoform, l-Amino acid oxidase (LAAO), referred to as Balt-LAAO-II, from ...
Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability
Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability
Staphylococcus aureus is a prevalent pathogen responsible for healthcare and community-acquired infections, which lead to ...
Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells
Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells
This study investigates the effects of Temporin-Rb, an antimicrobial peptide, on A549 cells’ viability and pro-infla...
Improving the Antibacterial Activity of Tryptophan-Containing Peptide Nanostructures Through Self-Assembly
Improving the Antibacterial Activity of Tryptophan-Containing Peptide Nanostructures Through Self-Assembly
Antimicrobial peptides (AMPs) are frequently distributed in the tissues and organs of animals to exhibit broad-spectrum ac...
Correction: Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NFκB and MAPK Activation
Correction: Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NFκB and MAPK Activation
Correction to: International Journal of Peptide Research and Therapeutics (2023) The original v...
Peptidomic Analysis and Potential Bioactive Peptides Identification Targeting Endometrial Cancer
Peptidomic Analysis and Potential Bioactive Peptides Identification Targeting Endometrial Cancer
Existing evidence has explained the critical role of endogenous peptides in cancers, however, the peptidomic profile and f...
BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines
BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines
BMAP-27 peptide is reported to possess apoptotic and anti-proliferative effects against cancer cells but the actual mechan...
Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NF-κB and MAPK Activation
Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NF-κB and MAPK Activation
The combined use of walnut meal peptides and ellagic acid demonstrated synergistic anti-inflammatory properties, which cou...
In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12
In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12
Antimicrobial peptides are thought to be promising antibiotic substitutes for a variety of multidrug-resistant bacteria. N...
Aspartame, a Synthetic Dipeptide Mediated Biochemical and Histopathological Alterations in Hepato-nephric Tissues of Mice and Pharmaceutical Intervention by Sesame Oil
Aspartame, a Synthetic Dipeptide Mediated Biochemical and Histopathological Alterations in Hepato-nephric Tissues of Mice and Pharmaceutical Intervention by Sesame Oil
Aspartame is an artificial sweetener, used worldwide and is one of the most controversial food additives, regarding its sa...
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