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Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Nowadays, design of cytotoxic agents based on microbial toxins is attracted for researchers. Pertussis-like toxin subunit ...
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial peptides (AMPs) are small cationic or amphipathic molecules that are produced by both prokaryotic and eukary...
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
This bibliometric analysis delves into the latest research on protein hydrolysates from fish, examining its potential to c...
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
Dengue, a significant mosquito-borne disease, presents a global health challenge with limited treatment options. Recently,...
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
FOXM1 is a crucial oncogenic transcription factor involved in almost all cancer hallmark pathways across all cancer types....
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
In recent years, as cancer immunotherapeutic approaches continue to be intensively investigated, therapeutic cancer vaccin...
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
We have previously shown that lyophilized mixtures of six- and twelve-melanoma peptide vaccines retain stability, purity, ...
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Antimicrobial peptides (AMPs) have garnered attention for their differential regulation in cancers like oral squamous cell...
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Bacteriocins are membrane-acting peptides and generally kill closely related bacteria using pore formation. In this study,...
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
In this study, an antimicrobial protein (AMP) from the epidermis of catfish (Clarias batrachus) was purified and character...
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
In this comprehensive investigation, we conducted a rigorous analysis of antimicrobial peptides (AMPs) within two venomous...
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Diabetes mellitus (DM) is a chronic endocrine disorder with lifelong implications. The prevalence of this condition is ste...
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Eupolyphaga sinensis Walker (ESW), an animal drug in traditional Chinese medicine, has been used clinically for thousands ...
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate
The peptide melittin is a promising possibility for cancer treatment. The present research evaluated the anticancer impact...
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Evaluation of Anti-endotoxin Activity, Hemolytic Activity, and Cytotoxicity of a Novel Designed Peptide: An In Silico and In Vitro Study
Endotoxin, also identified as lipopolysaccharide (LPS), is considered the pathogenic factor of septic shock triggered by G...
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties enco...
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptides, as therapeutic agents, can mimic the actions of molecules involved in inflammatory disorders. Antimicrobial pept...
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
π-Stacking Interactions Involved in Gynecologic Tankyrase-1/Inhibitor Recognition and Association: Implications for Rational Design of Aromatic Pentapeptide Ligands
Human tankyrase-1 is an important regulator of poly(ADP-ribosyl)ation (PARylation) of Wnt/β-catenin signaling and has...
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens
Kyotorphin (KTP) dipeptide (l-Tyrosine-l-Arginine) and their derivatives possess a multitude of functions, qualifying them...
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Apelin is Peptide Increasing Tolerance of Organs and Cells to Hypoxia and Reoxygenation. The Signaling Mechanism
Over the last three decades, treatment of stroke and acute myocardial infarction (AMI) has been improved, but it has stagn...
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1
Viral infections are continually emerging with new characteristics and the potential to cause outbreaks or pandemics. Ther...
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
In vitro and in silico Evaluation of the Anti-Biofilm Activity of Histatin 5 against Streptococcus mutans
Dental caries is a prevalent and costly disease throughout the world. Streptococcus mutans is widely recognized as one of ...
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Design and Characterization of Anticancer Peptides Derived from Snake Venom Metalloproteinase Library
Snake venom metalloproteinases (SVMPs) are enzymatic proteins found in snake venom and are known for their diverse biologi...
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, an inhibitor of voltage-gated sodium and potassium channels, is derived from the venom of the spider Chilobrachys ...
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Naturally Occurring Imidazole Peptides, Carnosine and Anserine Inhibit the Degranulation of Mast Cells and Basophils by Modulating Intracellular Signaling
Imidazole peptides possess multiple functions, including antioxidant effects, although their biological activities are lar...
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Correction: Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis
Gross morphology of knee joint surfaces; femoral condyles (F) and tibial plateaus (T). Arrowheads indicate the MIA-induced...
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use
Antimicrobial peptides (AMPs) are promising candidates for the development of new drugs. However, thorough studies on the ...
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Anti-Biofilm Effects of Melittin: Lessons Learned and the Path Ahead
Biofilm formation empowers microorganisms to withstand clearance mechanisms produced by host and synthetic sources. Biofil...
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers....
Cytotoxic Activity of A New Isoform l-Amino Acid Oxidase (Balt-LAAO-II) From Bothrops alternatus (Urutu) Snake Venom in Human Leukemic HL60 Cells
Cytotoxic Activity of A New Isoform l-Amino Acid Oxidase (Balt-LAAO-II) From Bothrops alternatus (Urutu) Snake Venom in Human Leukemic HL60 Cells
In this study, we describe the isolation of a new isoform, l-Amino acid oxidase (LAAO), referred to as Balt-LAAO-II, from ...
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