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Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
This review aims to elucidate the mechanisms employed by Host Defense Peptides (HDPs) in propagating their effector functi...
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
Sec-isoamyl Mercaptan (SIT), a Multi-faceted Disulfide Based Protecting Group for Cysteine Thiol
The successful synthesis of a peptide requires the synchronization of several processes, including the efficient execution...
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Heterologous Production of Bacteriocin EMM1 from Pseudomonas Protegens and its Antimicrobial Activity against Multidrug-resistant Clinical Isolates
Bacteria produce antimicrobial compounds to compete for nutrients and space in particular habitat. Bacteria of the genus P...
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Morpholine Prevents the Formation of Aspartimide from β-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides
Despite significant advancements in peptide chemistry, the persistent occurrence of aspartimide formation during peptide s...
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
Adjuvant Potential of Lionfish Venom on LPS Activated Mammalian Macrophages
The lionfish, originally from the Indo-Pacific, has become established in the western Atlantic Ocean and the Caribbean Sea...
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
Investigating the Inhibitory Effect of Animal Antimicrobial Peptides on Gram-Positive and Gram-Negative Bacteria in Diabetic Foot Ulcers
One of the problems of diabetic patients is the formation of ulcers in the lower areas, especially the legs, and the treat...
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
Conformational Flexibility and Net Charge are Key Determinants for the Antimicrobial Activity of Peptide Uy234 Against Multidrug-resistant Bacteria
The antimicrobial activity of two peptides, Uy234 derived from the venom of the scorpion Urodacus yaschenkoi and a consens...
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Insulin Prodrugs with Programmed Chemical Release of an Intramolecular Cross-Link
Basal insulin therapy is conventionally achieved by one of two broad medicinal approaches that entail either protracted ab...
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
The melanocortin system has been implicated in regulating various physiological pathways including skin and hair pigmentat...
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Low Molecular Weight Peptides Derived from Iranian Scorpion (Odontobuthus bidentatus) Venom Induces Apoptosis in the Hepatocellular Carcinoma Cell Line (HepG2) in 3D Cell Culture
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. Natural compounds, such as...
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (C...
Recent Discoveries of Antifungal Activity in Plant Antimicrobial Peptides
Recent Discoveries of Antifungal Activity in Plant Antimicrobial Peptides
Antimicrobial peptides (AMPs) are positive-charged small molecules of less than 50 amino acids, with antibacterial and ant...
A Specialized and Comprehensive Resource of Antiviral Peptides against Ebola Virus
A Specialized and Comprehensive Resource of Antiviral Peptides against Ebola Virus
Ebola virus (EBOV), a member of the Filoviridae family, causes EBOV disease (EVD), a highly fatal and neglected tropical d...
Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview
Utilization of Antiviral Peptides in Treating Coronavirus Infection: An Overview
This review aims to elucidate the mechanisms employed by antiviral peptides in inhibiting coronaviruses as well as related...
Study of Image Processing Method for Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP/CPPS) Mice Model
Study of Image Processing Method for Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP/CPPS) Mice Model
We determine the prostatic interstitium area, the inflammation’s localization, and the impact of different doses on ...
Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application
Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application
The thymus is the main lymphoid organ that regulates the functions of the immune system, protecting against pathogens, tum...
In vivo Immunogenicity and Antigenicity of MAP-8 Peptides Derived from the Structural and Non-Structural Proteins of Canine Parvovirus Type 2
In vivo Immunogenicity and Antigenicity of MAP-8 Peptides Derived from the Structural and Non-Structural Proteins of Canine Parvovirus Type 2
Canine parvovirus is a viral disease associated with the infection with the canine parvovirus type 2 (CPV-2). Virus-attenu...
Biotinylated Heptapeptides with D-amino Acids Suppress Allergic Reactions by Inhibiting Mast Cell Activation and Antagonizing the Histamine Receptor
Biotinylated Heptapeptides with D-amino Acids Suppress Allergic Reactions by Inhibiting Mast Cell Activation and Antagonizing the Histamine Receptor
Mast cells play an important role in allergic reactions by releasing potent mediators, including histamine and platelet-ac...
Synthetic Studies of the Mutant Proinsulin Syndrome Demonstrate Correlation Between Folding Efficiency and Age of Diabetes Onset
Synthetic Studies of the Mutant Proinsulin Syndrome Demonstrate Correlation Between Folding Efficiency and Age of Diabetes Onset
Heterozygous mutations in the insulin gene can give rise to a monogenic diabetes syndrome due to toxic misfolding of the v...
Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Design and Expression of Recombinant cell Penetrating Protein Based on Tat and pertussis-like Toxin A and Evaluation of its Effects on the lung cancer
Nowadays, design of cytotoxic agents based on microbial toxins is attracted for researchers. Pertussis-like toxin subunit ...
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases
Antimicrobial peptides (AMPs) are small cationic or amphipathic molecules that are produced by both prokaryotic and eukary...
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
Fish Protein Hydrolysate Research Trends over the Last 5 Years and Future Research Predictions; a Bibliometric Analysis
This bibliometric analysis delves into the latest research on protein hydrolysates from fish, examining its potential to c...
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
Dengue, a significant mosquito-borne disease, presents a global health challenge with limited treatment options. Recently,...
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
FOXM1 is a crucial oncogenic transcription factor involved in almost all cancer hallmark pathways across all cancer types....
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
The Role and Development of Peptide Vaccines in Cervical Cancer Treatment
In recent years, as cancer immunotherapeutic approaches continue to be intensively investigated, therapeutic cancer vaccin...
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
Stability of Multi-Peptide Vaccines in Conditions Enabling Accessibility in Limited Resource Settings
We have previously shown that lyophilized mixtures of six- and twelve-melanoma peptide vaccines retain stability, purity, ...
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Exploring Therapeutic Potential: A Comprehensive Review of Antimicrobial Peptides in Oral Cancer Management
Antimicrobial peptides (AMPs) have garnered attention for their differential regulation in cancers like oral squamous cell...
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Weissellicin LM85 Purified from Weissella confusa LM85 Effluxes Potassium Ions and Depletes Proton Motive Force in Escherichia coli ATCC 25922
Bacteriocins are membrane-acting peptides and generally kill closely related bacteria using pore formation. In this study,...
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
Characterization of Novel Antimicrobial Peptides from the Epidermis of Clarias batrachus Catfish
In this study, an antimicrobial protein (AMP) from the epidermis of catfish (Clarias batrachus) was purified and character...
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
Diving into the Venom Apparatus Transcriptomes of Pterois antennata and Pterois radiata: Unearthing a Novel Genus-Specific Piscidin-3 Homolog and a Multifarious Repertoire of Antimicrobial Peptides
In this comprehensive investigation, we conducted a rigorous analysis of antimicrobial peptides (AMPs) within two venomous...
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