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Gene of the month: GATA3
Gene of the month: GATA3
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FOXL2: a gene central to ovarian function
FOXL2: a gene central to ovarian function
The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription fac...
Emerging mesenchymal tumour types and biases in the era of ubiquitous sequencing
Emerging mesenchymal tumour types and biases in the era of ubiquitous sequencing
IntroductionSince the late 1990s, molecular genetic techniques have accelerated developments in the field of soft tissue p...
Her2 low (but not negative): the newest biomarker on the block for gastro-oesophageal adenocarcinoma
Her2 low (but not negative): the newest biomarker on the block for gastro-oesophageal adenocarcinoma
In this issue of Journal of Clinical Pathology, Angerilli et al provide a detailed survey of the prevalence and characteri...
HER2-low in gastro-oesophageal adenocarcinoma: a real-world pathological perspective
HER2-low in gastro-oesophageal adenocarcinoma: a real-world pathological perspective
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Molecular characterisation of Hb Akron [{beta}52 (D3) Asp->Val] combined with thalassaemia in a Chinese family
Molecular characterisation of Hb Akron [{beta}52 (D3) Asp->Val] combined with thalassaemia in a Chinese family
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Independent reporting in oral and maxillofacial pathology
Independent reporting in oral and maxillofacial pathology
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Thrombin generation assay and lupus anticoagulant synergically distinguish populations of patients with antiphospholipid antibodies
Thrombin generation assay and lupus anticoagulant synergically distinguish populations of patients with antiphospholipid antibodies
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Polymorphisms of ACE and thrombophilic genes: risk for recurrent pregnancy loss
Polymorphisms of ACE and thrombophilic genes: risk for recurrent pregnancy loss
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One-step embedding method for maintaining orientation of pathological tissue specimens using agar thin films
One-step embedding method for maintaining orientation of pathological tissue specimens using agar thin films
AbstractPathological histology examination involves handling a variety of specimens that are cut according to regulations ...
Barretts oesophagus with indefinite for dysplasia shows high rates of prevalent and incident neoplasia in a UK multicentre cohort
Barretts oesophagus with indefinite for dysplasia shows high rates of prevalent and incident neoplasia in a UK multicentre cohort
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Droplet digital PCR (ddPCR) using FFPE DNA to assess methylation status of MGMT gene among patients with IDH mutant astrocytoma and IDH wild-type glioblastoma
Droplet digital PCR (ddPCR) using FFPE DNA to assess methylation status of MGMT gene among patients with IDH mutant astrocytoma and IDH wild-type glioblastoma
MGMT promoter methylation analysis in formalin-fixed paraffin-embedded (FFPE) tissues can be challenging since the DNA ob...
New kids on the block: FOS and FOSB gene
New kids on the block: FOS and FOSB gene
Gene and protein structure FOS (Fos proto-oncogene, activator protein 1 (AP-1) transcription factor subunit), a protein co...
Screening for and diagnosis of monoclonal gammopathy
Screening for and diagnosis of monoclonal gammopathy
Monoclonal gammopathy is a spectrum of disorders characterised by clonal proliferation of plasma cells or lymphocytes, whi...
Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology
Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is one of the most well-established precursors of pancreati...
Comprehensive characterisation of acinar cystic transformation of the pancreas: a systematic review
Comprehensive characterisation of acinar cystic transformation of the pancreas: a systematic review
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Establishment and validation of prognostic nomograms integrating histopathological features in patients with endocervical adenocarcinoma
Establishment and validation of prognostic nomograms integrating histopathological features in patients with endocervical adenocarcinoma
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Comparison of two pathological processing methods for large endoscopic submucosal dissection (ESD) specimens
Comparison of two pathological processing methods for large endoscopic submucosal dissection (ESD) specimens
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Proposal to distinguish HER2-low from HER2-normal breast cancer by in situ hybridisation
Proposal to distinguish HER2-low from HER2-normal breast cancer by in situ hybridisation
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Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology
Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology
IntroductionSerological tests are commonly used diagnostic tools in a broad medical field, spanning from infectiology1 2 t...
IGH cytogenetic abnormalities can be detected in multiple myeloma by imaging flow cytometry
IGH cytogenetic abnormalities can be detected in multiple myeloma by imaging flow cytometry
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Quantification of human embryonic {zeta}-globin chains in Southeast Asian deletion (--SEA) carriers
Quantification of human embryonic {zeta}-globin chains in Southeast Asian deletion (--SEA) carriers
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Performance evaluation and clinical impact of the Oncomine Myeloid Research Assay for gene expression analysis in myeloid haematologic malignancies
Performance evaluation and clinical impact of the Oncomine Myeloid Research Assay for gene expression analysis in myeloid haematologic malignancies
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Artificial intelligence (AI) molecular analysis tool assists in rapid treatment decision in lung cancer: a case report
Artificial intelligence (AI) molecular analysis tool assists in rapid treatment decision in lung cancer: a case report
IntroductionLeptomeningeal spread is one of the most devastating complications of non-small cell lung cancer (NSCLC) with ...
SOX10
SOX10
The SRY-related HMG-box (SOX) family of transcription factors are important in determining the differentiation of a cell d...
57-year-old woman with purpura fulminans and acute kidney injury
57-year-old woman with purpura fulminans and acute kidney injury
Clinical presentationA 57-year-old woman was admitted to Peking University First Hospital with a fever (temperature 38.5°C...
Through the looking crystal: clarifying the pathogenesis and laboratory work-up of cryocrystalglobulinaemia
Through the looking crystal: clarifying the pathogenesis and laboratory work-up of cryocrystalglobulinaemia
Cryoglobulins are immunoglobulins that precipitate or gel out of serum at temperatures less than 37°C and resolubilise on ...
Cost analysis of archives in the pathology laboratories: from safety to management
Cost analysis of archives in the pathology laboratories: from safety to management
Archives in pathology: a historical rebusThe archives in pathology are crucial, but at the same time, they are the least-o...
New autopsy technique in COVID-19 positive dead bodies: opening the thoracic cavity with an outlook to reduce aerosol spread
New autopsy technique in COVID-19 positive dead bodies: opening the thoracic cavity with an outlook to reduce aerosol spread
WHAT IS ALREADY KNOWN ON THIS TOPICPathological or Medico-legal autopsies have been the cornerstone for the determination ...
Verification and validation of the anti-PD-L1 antibody, Clone 22C3 on a laboratory-developed test
Verification and validation of the anti-PD-L1 antibody, Clone 22C3 on a laboratory-developed test
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