SCI时时刷

search
+
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, ...
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
Abstract—Breast cancer is the most common type of cancer among women. The study of the mechanisms of metastasis, the...
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of bio...
Stochastic Packaging of Cas Proteins into Exosomes
Stochastic Packaging of Cas Proteins into Exosomes
Abstract—CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, such a...
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Abstract—Spore-forming bacteria have a unique resistance to negative environmental conditions, including aggressive ...
Prime-Editing Methods and pegRNA Design Programs
Prime-Editing Methods and pegRNA Design Programs
Abstract—It has been 10 years since CRISPR/Cas technology was applied to edit the genomes of various organisms. Its ...
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Stress can play a significant role in arterial hypertension and many other complications of cardiovascular diseases. Consi...
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Abstract—Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been st...
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
Abstract—Production of extracellular membrane vesicles plays an important role in communication in bacterial populat...
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Current data on the molecular mechanisms of liver fibrosis and cirrhosis fail to fully explain all stages of their develop...
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
The CRISPR/Cas9 technique has emerged as a powerful and promising tool for precise genomic integration, which applied to v...
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Flowering time plays an important role in crop regional adaptation, yield and reproductive success. ABRE BINDING FACTORs (...
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
The cadherin superfamily molecules, functioning as cell adhesion molecules, are recognized to play roles in both physiolog...
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Microglia phagocytosis plays an important role in the pathogenesis of neurodegeneration. Defects or dysfunction of microgl...
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs) are involved in many cellular processes while displaying high tissue specificity. In contra...
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100...
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Calcitonin is a 32-amino acid peptide, which causes a decrease in blood calcium levels and bone resorption in the human bo...
Metabolic Heterogeneity of Tumors
Metabolic Heterogeneity of Tumors
Abstract—Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates seriou...
Nitric Oxide(II) in the Biology of Chlorophyta
Nitric Oxide(II) in the Biology of Chlorophyta
Abstract—NO is a gaseous signaling redox-active molecule that functions in various eukaryotes. However, its synthesi...
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Abstract—One of the key regulators of hematopoietic stem cell (HSC) maintenance is cellular metabolism. Resting HSCs...
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
δ-Aminolevulinic acid dehydratase (ALAD) is a key enzyme of the cytoplasmic heme biosynthesis pathway. The primary st...
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Abstract—Low molecular-weight thiols as glutathione and cysteine are an important part of the cell’s redox reg...
The Redox-Catalytic Properties of Cobalamins
The Redox-Catalytic Properties of Cobalamins
Abstract—Vitamin B12, or cobalamin, is essential for normal body function and is used in the therapies of different ...
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Abstract—Changes in the activity of antioxidant systems in Escherichia coli during phosphate starvation have been st...
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
Abstract—Plant polyphenols are characterized by a wide range of biological activities, including antioxidant propert...
Protein Repeats Show Clade-Specific Volatility in Aves
Protein Repeats Show Clade-Specific Volatility in Aves
Protein repeats are a source of rapid evolutionary and functional novelty. Repeats are crucial in development, neurogenesi...
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract—Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many ...
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Peripheral blood biomarkers are of particular importance to diagnose certain diseases including coronary artery disease (C...
Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active “Working Form” of Nitric Oxide System in Living Organisms: A Review
Dinityrosyl Iron Complexes with Thiol-Containing Ligands as a Functionally Active “Working Form” of Nitric Oxide System in Living Organisms: A Review
Experimental data were summarized to assume that dinitrosyl iron complexes (DNICs) with thiol-containing ligands are an en...
The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
Abstract—Hsp70 and hydrogen sulfide donors reduce inflammatory processes in human and animal cells. The biological a...
阅读更多
format_indent_increase