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Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
The development and creation of a new generation vaccines based on recombinant proteins that assemble into virus-like part...
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a h...
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
SINEs are mobile genetic elements of multicellular eukaryotes that arose during evolution from various tRNAs, as well as f...
Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins
Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins
The process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule ...
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a com...
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
As a result of molecular domestication of the gag gene of errantiviruses, the Gagr gene was formed in the genome of Drosop...
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles
ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various sta...
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from b...
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
Atherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a lon...
ArdA Protein Specificity against Type I Restriction–Modification Systems
ArdA Protein Specificity against Type I Restriction–Modification Systems
The ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead...
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small non-coding RNAs (sRNAs, also called sncRNAs) known as gene expression regulatory factors are capable of modulating m...
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, ...
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
Abstract—Breast cancer is the most common type of cancer among women. The study of the mechanisms of metastasis, the...
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of bio...
Stochastic Packaging of Cas Proteins into Exosomes
Stochastic Packaging of Cas Proteins into Exosomes
Abstract—CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, such a...
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Abstract—Spore-forming bacteria have a unique resistance to negative environmental conditions, including aggressive ...
Prime-Editing Methods and pegRNA Design Programs
Prime-Editing Methods and pegRNA Design Programs
Abstract—It has been 10 years since CRISPR/Cas technology was applied to edit the genomes of various organisms. Its ...
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Stress can play a significant role in arterial hypertension and many other complications of cardiovascular diseases. Consi...
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues
Abstract—Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been st...
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19
Abstract—Production of extracellular membrane vesicles plays an important role in communication in bacterial populat...
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis
Current data on the molecular mechanisms of liver fibrosis and cirrhosis fail to fully explain all stages of their develop...
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
Verification of CRISPR/Cas9 Activity In Vitro via SSA-Based Dual-Luciferase Reporter System
The CRISPR/Cas9 technique has emerged as a powerful and promising tool for precise genomic integration, which applied to v...
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Flowering time plays an important role in crop regional adaptation, yield and reproductive success. ABRE BINDING FACTORs (...
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
The cadherin superfamily molecules, functioning as cell adhesion molecules, are recognized to play roles in both physiolog...
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
Microglia phagocytosis plays an important role in the pathogenesis of neurodegeneration. Defects or dysfunction of microgl...
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs) are involved in many cellular processes while displaying high tissue specificity. In contra...
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins
The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100...
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
Calcitonin is a 32-amino acid peptide, which causes a decrease in blood calcium levels and bone resorption in the human bo...
Metabolic Heterogeneity of Tumors
Metabolic Heterogeneity of Tumors
Abstract—Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates seriou...
Nitric Oxide(II) in the Biology of Chlorophyta
Nitric Oxide(II) in the Biology of Chlorophyta
Abstract—NO is a gaseous signaling redox-active molecule that functions in various eukaryotes. However, its synthesi...
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