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Improving the Efficiency and Safety of Human Gene Editing by Selection of Optimal Guide RNAs for SpCAS9 and CAS12A
Improving the Efficiency and Safety of Human Gene Editing by Selection of Optimal Guide RNAs for SpCAS9 and CAS12A
Advances in CRISPR/Cas-mediated genome editing have opened up treatment alternatives for many human diseases, including HI...
πDMD Simulation as a Strategy for Refinement of AlphaFold2 Modeled Fuzzy Protein Complexes Structures
πDMD Simulation as a Strategy for Refinement of AlphaFold2 Modeled Fuzzy Protein Complexes Structures
Disordered proteins are of great interest due to their structural features, as they do not have well-defined three-dimensi...
Exploring the Role and Mechanism of miRNA Dysregulation in Chronic Intermittent Hypoxia-Induced Cognitive Decline in Rats
Exploring the Role and Mechanism of miRNA Dysregulation in Chronic Intermittent Hypoxia-Induced Cognitive Decline in Rats
This study aimed to explore the effects of chronic intermittent hypoxia (CIH) on learning, memory, and hippocampal miRNA e...
Label-Free Optical Biosensor for Analysis of Binding Kinetics of Smart Nanomaterials with Ligands
Label-Free Optical Biosensor for Analysis of Binding Kinetics of Smart Nanomaterials with Ligands
Stimulus-sensitive smart materials are activated by input signals and remain inactive until they arrive. Such materials ar...
TRIM56 Mediates Autophagy Inhibition in Esophageal Cancer
TRIM56 Mediates Autophagy Inhibition in Esophageal Cancer
Tripartite motif containing 56 (TRIM56) has been implicated in tumor development, but its role in esophageal cancer remain...
Enveloped Virus Entry as a Pharmacological Target: Viral Membrane Fusion Machineries and Their Inhibitors
Enveloped Virus Entry as a Pharmacological Target: Viral Membrane Fusion Machineries and Their Inhibitors
Enveloped virus entry into the host cell mediated by the viral fusion glycoproteins represents an earliest step in viral i...
Development of Multiplex Real-Time RT–PCR to Determine the Expression Levels of Toll-Like Receptor Genes
Development of Multiplex Real-Time RT–PCR to Determine the Expression Levels of Toll-Like Receptor Genes
Immune response gene expression analysis is an important task in studies of interactions between a host and an infectious ...
DNA Vaccine Technologies: Design and Delivery
DNA Vaccine Technologies: Design and Delivery
The COVID-19 pandemic has triggered the development of new directions in vaccine development, among which DNA- and mRNA-ba...
Autophagy Impairment in Parkinson’s Disease: Approaches to Therapy
Autophagy Impairment in Parkinson’s Disease: Approaches to Therapy
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and is characterized by progressive m...
Substrate Behavior of Dissimilar Cy5-Deoxypyrimidine Nucleotides in PCR with DNA Templates of Different GC Compositions
Substrate Behavior of Dissimilar Cy5-Deoxypyrimidine Nucleotides in PCR with DNA Templates of Different GC Compositions
The substrate properties of six pairs of fluorescently labeled deoxyuridine and deoxycytidine triphosphates (Cy5-dUTPs and...
De Novo Gene Birth
De Novo Gene Birth
According to classic ideas, new genes emerge from old genes by duplication or horizontal transfer. Analyses of a large num...
Omics Study of Ovarian Malignancies: From Urine Metabolomic Profile to Minimally Invasive MicroRNA Markers
Omics Study of Ovarian Malignancies: From Urine Metabolomic Profile to Minimally Invasive MicroRNA Markers
A search for efficient biomarkers of ovarian cancer is one of the current trends in gynecologic oncology. Metabolic profil...
Transcriptomics and the “Curse of Dimensionality”: Monte Carlo Simulations of ML-Models as a Tool for Analyzing Multidimensional Data in Tasks of Searching Markers of Biological Processes
Transcriptomics and the “Curse of Dimensionality”: Monte Carlo Simulations of ML-Models as a Tool for Analyzing Multidimensional Data in Tasks of Searching Markers of Biological Processes
High-throughput transcriptomic research methods provide the assessment of a vast number of factors valuable for researcher...
Substrate Efficiency of Cy5-Modified Derivatives of Deoxyuridine and Deoxycytidine in the Rolling Circle Amplification
Substrate Efficiency of Cy5-Modified Derivatives of Deoxyuridine and Deoxycytidine in the Rolling Circle Amplification
The kinetics of amplification and the features of individual and simultaneous incorporation of modified deoxynucleoside tr...
Marine Fungi: In Search of New Antibacterial Drugs
Marine Fungi: In Search of New Antibacterial Drugs
Studies of antibacterial secondary metabolites of marine micromycete fungi as an element of a modern strategy for the sear...
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and poses a severe threat to human health. Gink...
Human eRF1 Translation Regulation
Human eRF1 Translation Regulation
Eukaryotic translation release factor eRF1 is an important cellular protein that plays a key role in translation terminati...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity wi...
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Transglutaminases are enzymes that carry out post-translational modifications of proteins and participate in the regulatio...
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Pancreatic Ductal AdenoCarcinoma (PDAC) is characterized by a poor prognosis and is poorly amenable to modern therapies. A...
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
Vimentin intermediate filaments are dynamic structures that are able to move in cytoplasm owing to activity of the motor p...
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Serine/threonine protein kinase ATM (ataxia-telangiectasia mutated) performs a number of aging-related functions in the ce...
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of...
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Klebsiella oxytoca is a causative agent of various community-acquired and nosocomial infections, including urinary tract i...
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication for...
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 an...
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Transposable elements (TEs) increase the frequency of spontaneous mutations in the genome and are capable of altering the ...
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory respiratory disease. T...
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