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Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm
Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm
Depending on the region of the aorta involved in the aneurysm, it can be categorized as a thoracic aortic aneurysm (TAA) o...
Disease progression modeling with temporal realignment: An emerging approach to deepen knowledge on chronic diseases
Disease progression modeling with temporal realignment: An emerging approach to deepen knowledge on chronic diseases
Clinical studies on chronic disease progression, especially on the trajectory of biochemical or imaging markers that refle...
Therapeutic targeting of DNA methylation alterations in cancer
Therapeutic targeting of DNA methylation alterations in cancer
DNA methylation, one of the most well-characterized epigenetic modifications in mammals, plays a critical role in a variet...
Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
5-HT2aR5-Hydroxytryptamine (Serotonin) Receptor 2 AAHNAdult hippocampal neurogenesisALSAmyotrophic Lateral SclerosisBDNFBr...
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
Cytochrome P450 enzymes (P450) consist of a family of membrane-bound hemeproteins that are mainly expressed in the human l...
Cisplatin in the era of PARP inhibitors and immunotherapy
Cisplatin in the era of PARP inhibitors and immunotherapy
Cisplatin, also called Cis-diamminedichloridoplatinum(II), is a platinum (Pt)-based compound widely used for cancer treatm...
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
KeywordsUltramicronized N-palmitoylethanolamineChronic painAnalgesicsAdd-onPreclinical studiesClinical studiesAbbreviation...
Pharmacological potential of cyclic nucleotide signaling in immunity
Pharmacological potential of cyclic nucleotide signaling in immunity
Nucleotides are essential components of living organisms. From genetic information storage to energy production, nucleotid...
The role of lidocaine in cancer progression and patient survival
The role of lidocaine in cancer progression and patient survival
Local anesthetics are crucial in clinical practice, being among the most utilized medications during invasive procedures, ...
Organic cation transporters in psychiatric and substance use disorders
Organic cation transporters in psychiatric and substance use disorders
Psychiatric and substance use disorders pose significant public health burdens across the globe. An estimated 970 million ...
Clinical advances in TNC delivery vectors and their conjugate agents
Clinical advances in TNC delivery vectors and their conjugate agents
Tenascin C (TNC), a glycoprotein that is abundant in the tumor extracellular matrix (ECM), is strongly overexpressed in tu...
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Available online 7 December 2023, 108576Author links open overlay panel, , , , , , , , , , AbstractRNA ac4C modification i...
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Dementia is a progressive neurodegenerative disease that develops most commonly in late adulthood and is predominantly cha...
Repurposing of pexidartinib for microglia depletion and renewal
Repurposing of pexidartinib for microglia depletion and renewal
Available online 3 December 2023, 108565Author links open overlay panel, , , AbstractPexidartinib (PLX3397) is a small mol...
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by three core impairments: impaired communic...
Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: Current perspectives and future challenges
Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: Current perspectives and future challenges
Chronic liver diseases (CLDs) are the leading cause of liver-related fatalities, accounting for 2 million deaths yearly (D...
Emerging role of immune cells as drivers of pulmonary fibrosis
Emerging role of immune cells as drivers of pulmonary fibrosis
Pulmonary fibrosis is an irreversible condition where the tissue (interstitium) surrounding the small air sacs (alveoli) i...
Retinoid X receptor agonists as selective modulators of the immune system for the treatment of cancer
Retinoid X receptor agonists as selective modulators of the immune system for the treatment of cancer
Retinoid X receptors (RXRs) are essential modulators of human physiology and attractive targets for treating cancer (Altuc...
What matters in aging is signaling for responsiveness
What matters in aging is signaling for responsiveness
Aging has traditionally been viewed as a multifaceted process influenced by various factors, including genetics, environme...
From exploring cancer and virus targets to discovering active peptides through mRNA display
From exploring cancer and virus targets to discovering active peptides through mRNA display
At first glance, cancer and viral infections have nothing in common – and, indeed, the differences run deep. However, from...
Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance
Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance
Antibiotic resistance has become a global health crisis. Antibiotics are undoubtedly indispensable in the fight against ba...
Biologics for severe asthma and beyond
Biologics for severe asthma and beyond
Asthma remains a very common chronic disease worldwide and poses a huge burden on individuals and societies (García-Marcos...
Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?
Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?
AGBadjustable gastric bandingAgRPagouti-related peptideATMadipose tissue macrophagesATPadenosine triphosphateBAIBAβ-aminoi...
NLRP3 and cancer: Pathogenesis and therapeutic opportunities
NLRP3 and cancer: Pathogenesis and therapeutic opportunities
In 2010 we published a provocative review entitled “Why not treat human cancer with interleukin-1 blockade?” and suggested...
Boron in cancer therapeutics: An overview
Boron in cancer therapeutics: An overview
Boron has gradually resurfaced for its medical importance after several studies proved its nutrient value and medicinal pr...
Severe hypertriglyceridemia: Existing and emerging therapies
Severe hypertriglyceridemia: Existing and emerging therapies
Severe hypertriglyceridemia (sHTG) has been arbitrarily defined by different national guidelines as either triglyceride (T...
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Epigenetic regulation encompasses the engagement of adaptive cellular pathways influenced by environmental factors and met...
Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons
Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons
Chronic pain is defined as any type of pain that persists more than three months following the initial triggering event (S...
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Ischemic stroke refers to blood supply disorders that result in cerebral ischemia and hypoxia and ultimately lead to ische...
Presynaptic glutamate receptors in nociception
Presynaptic glutamate receptors in nociception
Acute, physiological pain serves as an important warning signal in our body to avoid dangerous stimuli or environment, man...
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