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Nuclear mechanotransduction on skin stem cell fate regulation
Nuclear mechanotransduction on skin stem cell fate regulation
Mammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite...
Engines of change: Nonmuscle myosin II in mechanobiology
Engines of change: Nonmuscle myosin II in mechanobiology
The emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to th...
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Editorial overview: Functional specialization of the cytoskeleton in diverse cell types
Adele L. Marston is professor of cell biology at the University of Edinburgh, a wellcome investigator and director of the ...
GFAP-isoforms in the nervous system: Understanding the need for diversity
GFAP-isoforms in the nervous system: Understanding the need for diversity
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells...
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells
Lipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in...
Organelle adaptations in response to mechanical forces during tumour dissemination
Organelle adaptations in response to mechanical forces during tumour dissemination
Cell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastas...
Editorial overview: Navigating the landscapes of mechanobiology and cell–cell interactions
Editorial overview: Navigating the landscapes of mechanobiology and cell–cell interactions
Staffan Strömblad is Professor of Clinical Molecular Biology at Karolinska Institutet (KI) since 2009 and performs researc...
Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
Recent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper e...
Machines, mechanics and mechanisms of cells and tissues
Machines, mechanics and mechanisms of cells and tissues
Anne Straube is a Professor and Head of Bio-Medical Sciences at the University of Warwick. She trained as a biochemist and...
The multidimensional roles of intermediate filaments - bridging genetic diversity with form, functions, and targets
The multidimensional roles of intermediate filaments - bridging genetic diversity with form, functions, and targets
John E. Eriksson, PhD, is Director General of Euro-BioImaging ERIC (www.eurobioimaging.eu), the pan-European organization ...
Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography
Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography
KeywordsCryo-electron tomographyMolecular sociologyActin filamentsTomogram acquisitionAutomationDeep learning-based data a...
Molecular cartography within axons
Molecular cartography within axons
Recent advances in imaging methods begin to further illuminate the inner workings of neurons. Views of the axonal landscap...
Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration
Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration
Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and tissue integrity. In vivo, these ...
The emerging tools for precisely manipulating microtubules
The emerging tools for precisely manipulating microtubules
KeywordsMicrotubulePost-translational modificationsOptogeneticsChemogeneticsMicrotubule-targeting agentSpastinKataninFRBFK...
The molecular architecture of the ciliary transition zones
The molecular architecture of the ciliary transition zones
Cilia and flagella are specialized eukaryotic organelles projecting from the surface of eukaryotic cells that play a centr...
Endoplasmic reticulum – condensate interactions in protein synthesis and secretion
Endoplasmic reticulum – condensate interactions in protein synthesis and secretion
In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independentl...
Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer
Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer
Macropinocytosis (MP), the actin-dependent bulk uptake of extracellular fluids, plays a central role in nutrient scavengin...
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Throughout history, the liver has captivated human interest; spanning from the ancient ritual of hepatoscopy, where the li...
Cell cycle control by cell-matrix interactions
Cell cycle control by cell-matrix interactions
Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. ...
The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow
Research over the last two decades has provided compelling evidence that the physical principle of molecular spatiotempora...
AAA ATPase protein–protein interactions as therapeutic targets in cancer
AAA ATPase protein–protein interactions as therapeutic targets in cancer
The ATPases Associated with Diverse Cellular Activities (AAA ATPases) represent a family of enzymes found in all domains o...
Cytoskeletal dynamics in parasites
Cytoskeletal dynamics in parasites
Volume 86, February 2024, 102277Author links open overlay panel, , AbstractCytoskeletal dynamics are essential for cellula...
How nuclear envelope dynamics can direct laminopathy phenotypes
How nuclear envelope dynamics can direct laminopathy phenotypes
The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physical...
Microtubule control of migration: Coordination in confinement
Microtubule control of migration: Coordination in confinement
The microtubule cytoskeleton has a well-established, instrumental role in coordinating cell migration. Decades of research...
Mechanisms and functions of multiciliary coordination
Mechanisms and functions of multiciliary coordination
Ciliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate...
Disturbed endothelial cell signaling in tumor progression and therapy resistance
Disturbed endothelial cell signaling in tumor progression and therapy resistance
Endothelial cells (ECs) not only form a semi-permeable monolayer with anti-thrombotic properties, but also release angiocr...
The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation
The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation
KeywordsOxidative stressCysteine modificationOxidation and lipoxidationVimentinRedox signalingAbbreviationsGFAPglial fibri...
The keratin-desmosome scaffold of internal epithelia in health and disease – The plot is thickening
The keratin-desmosome scaffold of internal epithelia in health and disease – The plot is thickening
Keratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tiss...
Stress-protecting harbors for hematopoietic stem cells
Stress-protecting harbors for hematopoietic stem cells
Hematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and m...
Drivers of heterogeneity in the glioblastoma immune microenvironment
Drivers of heterogeneity in the glioblastoma immune microenvironment
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a median overall survival (OS) of approxima...
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