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Metallic nanomedicine in cancer immunotherapy
Available online 14 July 2025Author links open overlay panel, , , , , , , , AbstractImmunotherapy has become a pivotal mod...
Photodynamic enhancement of PROTAC prodrug activation in hypoxic tumors
Available online 14 July 2025Author links open overlay panel, , , , , AbstractProteolysis-targeting chimeras (PROTACs) hav...
Evolution-guided design of mini-protein for high-contrast in vivo imaging
Available online 15 July 2025Author links open overlay panel, , , , , , , , , , , , , , , , , , , …AbstractTraditional dev...
A computational medicine framework integrating multi-omics, systems biology, and artificial neural networks for Alzheimer's disease therapeutic discovery
Available online 16 July 2025Author links open overlay panel, , , , , , , AbstractThe translation of genetic findings from...
Evidence that metformin promotes fibrosis resolution via activating alveolar epithelial stem cells and FGFR2b signaling
Available online 17 July 2025Author links open overlay panel, , , , , , , , , , , , , , , AbstractIdiopathic pulmonary fib...
Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy
Available online 17 July 2025Author links open overlay panel, , , , , , AbstractThe aging microenvironment, as a key drive...
Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insights
Available online 17 July 2025Author links open overlay panel, , , , , AbstractMacrophages are immune cells capable of exer...
A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief
Available online 19 July 2025Author links open overlay panel, , , , , , , , , , , , , , , AbstractOsteoarthritis (OA) caus...
VIRMA-mediated SHQ1 m6A modification enhances liver regeneration through an HNRNPA2B1-dependent mechanism
Available online 21 July 2025Author links open overlay panel, , , , , , , , , AbstractN6-Methyladenosine (m6A) modificatio...
Ischemic stroke and intervention strategies based on the timeline of stroke progression: Review and prospects
Available online 23 July 2025Author links open overlay panel, , , , AbstractIschemic stroke (IS), a leading cause of morbi...
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway
Available online 23 July 2025Author links open overlay panel, , , , , AbstractChemotherapeutic drugs, such as cisplatin an...
Progress and challenges of functionalized bacterial encapsulation: a novel biotechnology for next-generation biotherapeutics
Available online 23 July 2025Author links open overlay panel, , , , , , , , , , , , , , AbstractThe disturbance of the hum...
mRNA display-enabled discovery of proximity-triggered covalent peptide–drug conjugates
Available online 24 July 2025Author links open overlay panel, , , , , , , , , , , , , AbstractPeptide–drug conjugates (PDC...
Targeting oncogenic K-RAS mutants with small-molecule degrader XMU-MP-9 through NEDD4-1
Available online 25 July 2025Author links open overlay panel, , , , , , , , , , , , AbstractK-RAS mutations represent a mo...
Artificial intelligence-driven multi-omics approaches in Alzheimer’s disease: Progress, challenges, and future directions
Available online 25 July 2025Author links open overlay panel, , , , , , , , , AbstractAlzheimer’s disease (AD) is a progre...
Astrocytic dopamine D1 receptor modulates glutamatergic transmission and synaptic plasticity in the prefrontal cortex through D-serine
Available online 26 July 2025Author links open overlay panel, , , , , , , , , , , , , , , , , AbstractThe prefrontal corte...
Dissecting the effects of 223Radium on the bone microenvironment
Available online 26 July 2025Author links open overlay panel, , , , , , , , , , AbstractRadium-223 (223Ra) is a bone-seeki...
A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis
Available online 29 July 2025Author links open overlay panel, , , , , , , , , , , , , , , , , , , …AbstractCardiac fibrosi...
Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker
Available online 30 July 2025Author links open overlay panel, , , , , , , , , , , AbstractTriple-negative breast cancer (T...
Application of computational methods in the drug discovery and development of Alzheimer’s disease
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder marked by the accumulation of amyloid plaques and neuro...
The PGAM5–NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
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Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
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Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer’s disease
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Facilitation of mucosal healing by estrogen receptor β in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells
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Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A
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YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease
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Silencing excessive stress response of neurons — a new approach to treat neurodegeneration diseases
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“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation
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Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders
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Author correction to “The neuroprotective effect of traditional Chinese medicinal plants—A critical review” [Acta Pharm Sin B 13 (2023) 3208–3237]
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