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The PGAM5–NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
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Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
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Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer’s disease
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Facilitation of mucosal healing by estrogen receptor β in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells
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Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A
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YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease
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Silencing excessive stress response of neurons — a new approach to treat neurodegeneration diseases
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“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation
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Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders
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Author correction to “The neuroprotective effect of traditional Chinese medicinal plants—A critical review” [Acta Pharm Sin B 13 (2023) 3208–3237]
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Author correction to ‘Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication’ [Acta Pharmaceutica Sinica B 9 (2019) 769-781].
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Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
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GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway
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Real-world efficacy and safety of azvudine in hospitalized older patients with COVID-19 during the omicron wave in China: A retrospective cohort study
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Author correction to “FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis” [Acta Pharm Sin B 14 (2024) 1605–1623]
Author correction to “FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis” [Acta Pharm Sin B 14 (2024) 1605–1623]
Available online 9 April 2024Author links open overlay panel, , , , , , , , , , , , , , , © 2024 The Author(s). Published ...
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Pancreatic cancerTumor adjacent normal tissue fibroblasts (NAF)DesmoplasiaExtracellular vesiclesExosomesTumor targetingOrm...
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
Available online 10 April 2024Author links open overlay panel, , , , , , , , , , , , , , , AbstractCoumarins, derived from...
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared...
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
3,5-JulolidinylAza-BODIPYNanocarriersNear-infrared IIFluorescence imagingAggregation-caused quenchingPolymeric micellesPol...
Characteristic roadmap of linker governs the rational design of PROTACs
Characteristic roadmap of linker governs the rational design of PROTACs
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging th...
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
ChemoimmunotherapyTargeted drug deliveryEndoplasmic reticulumEndoplasmic reticulum stressImmunogenic cell deathsiRNAExosom...
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Non-covalent PLpro inhibitorsAntiviral activityStructural-based drug designImidazo[4,5-b]pyridine scaffold© 2024 Published...
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer’s disease
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer’s disease
Available online 17 April 2024Author links open overlay panelAbstractAlzheimer’s disease (AD) is considered the most commo...
Author correction to ‘Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry’ [Acta Pharmaceutica Sinica B 10 (2020) 789–798]
Author correction to ‘Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry’ [Acta Pharmaceutica Sinica B 10 (2020) 789–798]
Available online 18 April 2024Author links open overlay panelKe Tang a b †, Xiaoyu Zhang a b †, Ying Guo a bShow moreRecom...
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation
AilanthoneMEOX1Pulmonary fibrosisJUNTGF-β1High-throughput screeningNatural product© 2024 The Author(s). Published by Elsev...
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Available online 22 April 2024Author links open overlay panel, , , , , , AbstractInherited genetic disorders of the liver ...
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Piezo1DGAT2SGLT1Lipid metabolismObesityMechanical sensingIntestinal lipid absorptionIntestinal glucose absorption© 2024 Th...
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
multiple myelomaPhenylalanineAmino acid metabolismNutrient deprivationCancer therapyEndoplasmic reticulum stressATF3Apopto...
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