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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic cancer
Pancreatic cancerTumor adjacent normal tissue fibroblasts (NAF)DesmoplasiaExtracellular vesiclesExosomesTumor targetingOrm...
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
Available online 10 April 2024Author links open overlay panel, , , , , , , , , , , , , , , AbstractCoumarins, derived from...
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared...
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
3,5-JulolidinylAza-BODIPYNanocarriersNear-infrared IIFluorescence imagingAggregation-caused quenchingPolymeric micellesPol...
Characteristic roadmap of linker governs the rational design of PROTACs
Characteristic roadmap of linker governs the rational design of PROTACs
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging th...
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Non-covalent PLpro inhibitorsAntiviral activityStructural-based drug designImidazo[4,5-b]pyridine scaffold© 2024 Published...
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer’s disease
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer’s disease
Available online 17 April 2024Author links open overlay panelAbstractAlzheimer’s disease (AD) is considered the most commo...
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation
AilanthoneMEOX1Pulmonary fibrosisJUNTGF-β1High-throughput screeningNatural product© 2024 The Author(s). Published by Elsev...
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Available online 22 April 2024Author links open overlay panel, , , , , , AbstractInherited genetic disorders of the liver ...
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Piezo1DGAT2SGLT1Lipid metabolismObesityMechanical sensingIntestinal lipid absorptionIntestinal glucose absorption© 2024 Th...
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
multiple myelomaPhenylalanineAmino acid metabolismNutrient deprivationCancer therapyEndoplasmic reticulum stressATF3Apopto...
PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification
PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification
Available online 24 April 2024Author links open overlay panel, , , , , , , , , , , , , , AbstractThe mucosal barrier is cr...
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer
Regulated cell death (RCD) is a controlled form of cell death orchestrated by one or more cascading signaling pathways, ma...
Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast
Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast
Available online 4 December 2023Author links open overlay panel, KeywordsbeigeBreastEpitheliail cellsscRNA-seqThermogenesi...
Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
Available online 18 November 2023Author links open overlay panel, , , , , , , , , , , , , , , , AbstractThe role of co-ago...
In situ autophagy regulation in synergy with phototherapy for breast cancer treatment
In situ autophagy regulation in synergy with phototherapy for breast cancer treatment
AutophagyTumor phototherapySynergistic sensitizationHCQTRANSFERRINDisulfide bond reconstructionGSHBiomimetic mineralized n...
Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing
Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing
Available online 18 November 2023Author links open overlay panel, , , , , , AbstractSynthetic chemistry plays an indispens...
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions
Intratumoral microbiota has become research hotspots, and emerges as a non-negligent new component of tumor microenvironme...
Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates
Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates
Available online 17 November 2023Author links open overlay panel, , , , , , , , , , , AbstractThe orphan nuclear receptor ...