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Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria
Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria
Significance Statement Proteinuria predicts accelerated decline in kidney function in CKD. The pa
Pkd2 Deficiency in Embryonic Aqp2+ Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease
Pkd2 Deficiency in Embryonic Aqp2+ Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease
Significance Statement Autosomal dominant polycystic kidney disease (ADPKD) is a devastating diso
Update on HD-Induced Multiorgan Ischemia: Brains and Beyond
Update on HD-Induced Multiorgan Ischemia: Brains and Beyond
Hemodialysis (HD) is a life-saving treatment for patients with kidney failure. However, patients req
Allocation and Utilization Patterns of Deceased Donor Kidneys for Preemptive Transplantation in the United States
Allocation and Utilization Patterns of Deceased Donor Kidneys for Preemptive Transplantation in the United States
1Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, N...
Age- and Race-Specific Changes in ESKD Incidence over Four Decades
Age- and Race-Specific Changes in ESKD Incidence over Four Decades
Significance Statement ESKD incidence has changed substantially in the past four decades, but dif
Cardiovascular-Kidney-Metabolic Health Syndrome: What Does the American Heart Association Framework Mean for Nephrology?
Cardiovascular-Kidney-Metabolic Health Syndrome: What Does the American Heart Association Framework Mean for Nephrology?
Overview of the American Heart Association's Cardiovascular-Kidney-Metabolic Syndrome Obesity, diabetes, and CK...
The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function
The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function
Background: Inorganic phosphate (Pi) is an essential mineral, and its plasma levels are tightly r
Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy Against Kidney Fibrosis
Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy Against Kidney Fibrosis
1Icahn School of Medicine at Mount Sinai, NY, NY 10029 2Rila Therapeutics Inc., South San Francisco, CA 94080...
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury
Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury
Background: The inflammatory response to acute kidney injury (AKI) likely dictates future renal h
Correction: The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care
Correction: The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care
Correction: The Primary-Secondary Care Partnership to Improv... : Journal of the American Society of Nephrology ...
Foxp1 is Required for Renal Intercalated Dell Differentiation and Acid-Base Regulation
Foxp1 is Required for Renal Intercalated Dell Differentiation and Acid-Base Regulation
Background Kidney collecting ducts are comprised of principal cells and intercalated cells, with
Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States
Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States
Key Points Nationally, 41% of kidney transplant candidates consented to receive high–Kidney Donor
Sensing Dying Cells in Health and Disease: The Importance of Kidney Injury Molecule-1
Sensing Dying Cells in Health and Disease: The Importance of Kidney Injury Molecule-1
Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain-1 (TIM-1), is
Integrated Single-Cell Transcriptomic Atlas of Human Kidney Endothelial Cells
Integrated Single-Cell Transcriptomic Atlas of Human Kidney Endothelial Cells
Background: Kidney endothelial cells are exposed to different microenvironmental conditions that
Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial
Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial
Background: Hyperuricemia is associated with elevated risks of cardiovascular and chronic kidney
Daprodustat and Heart Failure in CKD
Daprodustat and Heart Failure in CKD
Background: Patients with chronic kidney disease (CKD) are at higher risk for heart failure. The
Ondansetron and the Risk of Sudden Cardiac Death among Individuals Receiving Maintenance Hemodialysis
Ondansetron and the Risk of Sudden Cardiac Death among Individuals Receiving Maintenance Hemodialysis
Background: Individuals receiving hemodialysis have high incidence of sudden cardiac death and ar
Retraction: GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β–Induced Smad3 Phosphorylation
Retraction: GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β–Induced Smad3 Phosphorylation
Ai, Jun; Nie, Jing; He, Jiangbo; Guo, Qin; Li, Mei; Lei, Ying; Liu, Youhua; Zhou, Zhanmei; Zhu, Fengxin; Liang, Min; Cheng...
Point of Care Clinical Trials in Nephrology
Point of Care Clinical Trials in Nephrology
1Cooperative Studies Program Coordinating Center, VA Boston Healthcare System, Boston, MA 2Department of Bios...
Heterogeneity of Distal Convoluted Tubule Cells
Heterogeneity of Distal Convoluted Tubule Cells
Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National ...
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced AKI
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced AKI
Background Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors, but i
Oral Sodium Bicarbonate and Bone Turnover in CKD: A Secondary Analysis of the BASE Pilot Trial
Oral Sodium Bicarbonate and Bone Turnover in CKD: A Secondary Analysis of the BASE Pilot Trial
Background Treatment with alkali has been hypothesized to improve bone health in CKD by mitigatin
Dicarboxylic Acid Dietary Supplementation Protects Against Acute Kidney Injury
Dicarboxylic Acid Dietary Supplementation Protects Against Acute Kidney Injury
Introduction: Proximal tubules are rich in peroxisomes, which are damaged during AKI. Previous st
Prognostic Biomarkers in Kidney Transplantation: a Systematic Review and Critical Appraisal
Prognostic Biomarkers in Kidney Transplantation: a Systematic Review and Critical Appraisal
Background Despite the increasing number of biomarker studies published in the transplant literat
Racial and Ethnic Diversity is a Tool for Eliminating Unequal Racial and Ethnic Kidney Health
Racial and Ethnic Diversity is a Tool for Eliminating Unequal Racial and Ethnic Kidney Health
Dell Medical School, The University of Texas at Austin, Austin, TX Correspondence: Dr. Donald E. Wesson, Dell...
The B1 H+-ATPase (Atp6v1b1) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
The B1 H+-ATPase (Atp6v1b1) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
Background: Non-type-A intercalated cells (IC) in the collecting duct system express the luminal
Does Serum Creatinine Reflect Muscle Mass in Patients with Kidney Failure?
Does Serum Creatinine Reflect Muscle Mass in Patients with Kidney Failure?
1Section of Nephrology, Selzman Institute for Kidney Health, Baylor College of Medicine, Houston, Texas 2Sect...
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury
Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury
Background: Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors, but
Impact of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort
Impact of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort
Background: Excess mortality in hemodialysis patients is largely due to cardiovascular disease an
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder characte
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