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Management of Functional Neurological Disorder
Patients with functional neurological symptoms present to clinicians in a variety of clinical settings, although they are ...
Two Cases of Menstrual Psychosis: Not to Be Forgotten
Menstrual psychosis is not included in any current nosological system, posing challenges to clinicians for its identificat...
Severe Psychosis Due to Cushing Syndrome
Acute psychosis may be the initial manifestation of Cushing syndrome, but it can easily be overlooked, especially in patie...
The Superiority of Clozapine Over Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: Room for Doubt
Clozapine is associated with many adverse effects. Given the findings that olanzapine and risperidone may be as good as cl...
Levomilnacipran, but Not Duloxetine, Inhibits Serotonin and Norepinephrine Reuptake Throughout Its Therapeutic Range
Levomilnacipran and duloxetine are both potent serotonin reuptake inhibitors at all therapeutic regimens for MDD. Potent n...
Lumateperone as Adjunctive Therapy in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial
In patients with MDD with inadequate antidepressant response, adjunctive lumateperone 42 mg significantly improved depress...
It Takes a Village: A Multidisciplinary Approach to Catatonia in Pregnancy
Timely treatment of catatonia is crucial and outweighs the risk of exposure to the fetus.
N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial
Among individuals with PTSD and alcohol use disorder receiving CBT and either NAC or placebo, both groups had significant ...
Artificial Intelligence in Depression–Medication Enhancement (AID-ME): A Cluster Randomized Trial of a Deep-Learning-Enabled Clinical Decision Support System for Personalized Depression Treatment Selection and Management
This study provides preliminary evidence that longitudinal use of an AI-enabled clinical decision support system can impro...
Depression Remission and Response Rates and Anxiety Response as a Predictor of Depression Response in a Community Electroconvulsive Therapy Clinic
Anxiety symptoms may be a factor correlated with depression treatment response, suggesting potential utility in screening ...
Broad Differential Diagnoses in a Case of Catatonia Secondary to Clozapine Withdrawal
This case presents a complex clinical scenario in which no single diagnosis fully accounted for the presenting symptoms.
Effects of Intravenous Hydroxyzine Versus Haloperidol Monotherapy for Delirium: A Retrospective Study
Hydroxyzine showed a significantly higher rate of delirium improvement than haloperidol, with no significant difference in...
Maternal Cannabis Use During Pregnancy and Neuropsychiatric Adverse Outcomes During Childhood and Early Adult Life
Current research suggests that prenatal cannabis exposure is linked to many adverse outcomes, including psychosis pronenes...
Innovative Strands of Healing: Nurturing Recovery in a Case of Trichotillomania Via Tele-Based Habit Reversal Therapy
The authors present a case of trichotillomania in a patient who was managed via telepsychiatry-based habit reversal therap...
Baseline Cardiovascular Risk Factors in Patients With Severe Mental Illness (SMI) and Second Generation Antipsychotic Use From the Fixed Dose Intervention Trial of New England Enhancing Survival in SMI (FITNESS)
Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental il...
Inpatient Treatment of Suicidality: A Systematic Review of Clinical Trials
Effective, rapid treatments that target suicidality in psychiatric inpatients are scarce in the existing literature and in...
Sodium Valproate–Associated Psoriasis: A Case Report and Brief Literature Review
The authors present a rare case of exacerbation of psoriasiform eruptions in a patient who was prescribed sodium valproate...
Catatonia Associated With Post-Acute COVID-19 in a Young Child
A 4-year-old girl with high-functioning autism spectrum disorder experienced catatonia associated with the post-acute phas...
Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial
Although the primary endpoint was not met, BI 1358894 was well-tolerated with no increase in self-harm or suicidality.
Synopsis of the 2023 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline for the Management of Bipolar Disorder
This synopsis focuses on clinically relevant recommendations related to identification and management of bipolar disorder,...
Different Types of Love Activate the Brain Differently
Different Types of Love Activate the Brain Differently
New research maps the neural mechanisms behind different forms of love, revealing that each type activates distinct areas ...
Perinatal Timing of Obsessive-Compulsive Disorder Onset
Perinatal Timing of Obsessive-Compulsive Disorder Onset
Findings show that OCD is most likely to begin in the early postpartum, with a rapid transition from symptoms to disorder....
Can Emotional Dysregulation Help Explain Adolescent PTSD?
Can Emotional Dysregulation Help Explain Adolescent PTSD?
A new review highlights the connection between emotional dysregulation and post-traumatic stress disorder in adolescents a...
Unremitting Nausea Due to Lurasidone After Semaglutide Initiation
Unremitting Nausea Due to Lurasidone After Semaglutide Initiation
The authors describe a potential drug interaction between lurasidone and semaglutide causing new intolerable nausea follow...
Adalimumab-Associated Depressive Symptoms in a Patient With Vasculitis, Autoinflammation, Immunodeficiency, and Hematologic Defects Syndrome
Adalimumab-Associated Depressive Symptoms in a Patient With Vasculitis, Autoinflammation, Immunodeficiency, and Hematologic Defects Syndrome
A 16-year-old boy with vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome, who was taking ad...
Esmethadone Shows Potential in Difficult-to-Treat Depression
Esmethadone Shows Potential in Difficult-to-Treat Depression
Esmethadone showed mixed results in phase 3 trials with promising response and remission rates, especially in severe depre...
How NRx Could Upend the Fight Against Depression and Suicide
How NRx Could Upend the Fight Against Depression and Suicide
NRx Pharmaceuticals is developing a pair of promising new treatments for bipolar depression and suicidal ideation.
Weekly Mind Reader: What Do Hair Pulling and PTSD Have in Common?
Weekly Mind Reader: What Do Hair Pulling and PTSD Have in Common?
The Weekly Mind Reader explores trichotillomania and PTSD, the onset of OCD post-partum, and the risks of fetal ketamine e...
Study Reveals Differences Between Psilocybin, Escitalopram in Depression Treatment
Study Reveals Differences Between Psilocybin, Escitalopram in Depression Treatment
New research explores how psilocybin therapy and escitalopram alter brain dynamics in different ways to treat depression.
Surgeon General Issues Mental Health Advisory for Parents
Surgeon General Issues Mental Health Advisory for Parents
The Surgeon General has urged policy changes and cultural shifts to better support the mental health of parents and caregi...
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