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Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α1-proteinase inhibitor (α1...
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-quadruplexes (G4), non-canonical secondary DNA structures, have been intensively investigated for a long time. In eukary...
Effect of Ethanol on Platelet Biology
Effect of Ethanol on Platelet Biology
In recent years, there has been interest in the study of platelets, the functions of which, as it turned out, are not limi...
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Antioxidant and anti-ischemic properties of the pharmacological agonist of galanin receptor GalR2 WTLNSAGYLLGPβAH (Ga...
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
The analysis of cytochrome P450 transcripts was carried out by the nanopore sequencing in liver tissue samples of three do...
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Some brain-derived neurotrophic factor (BDNF)-targeted miRNAs such as miR-30a-5p may be associated with alcohol addiction;...
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
We studied the interaction of the antitumor agent abiraterone and its pharmacologically active metabolite D4A, which is pr...
The Integrin α3β1 Signaling in the Regulation of the SK-Mel-147 Melanoma Cell Senescence
The Integrin α3β1 Signaling in the Regulation of the SK-Mel-147 Melanoma Cell Senescence
Using a model of the human SK-Mel-147 melanoma cell line, it was shown that blocking the expression of integrin α3 ...
Comparative Analysis of Proteins Associated with 26S and 20S Proteasomes Isolated from Rabbit Brain and Liver
Comparative Analysis of Proteins Associated with 26S and 20S Proteasomes Isolated from Rabbit Brain and Liver
The fractions of 26S and 20S proteasomes have been isolated from the rabbit liver and the brain. According to mass spectro...
Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease
Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease
To date, there are no drugs that can prevent progressive destruction of lung tissue and small airway fibrosis in patients ...
Mechanisms of Development of Side Effects and Drug Resistance to Asparaginase and Ways to Overcome Them
Mechanisms of Development of Side Effects and Drug Resistance to Asparaginase and Ways to Overcome Them
Asparaginase is one of the most important chemotherapeutic agents against acute lymphoblastic leukemia, the most common fo...
Adrenodoxins and Their Role in the Cytochrome P450 Systems
Adrenodoxins and Their Role in the Cytochrome P450 Systems
The role of partner proteins in the formation of functional complexes in cytochrome P450 systems was investigated by means...
Screening Analysis of Proteolytic Enzymes and Their Inhibitors in the Leaflets of Epoxy-Treated Bioprosthetic Heart Valves Explanted due to Dysfunction
Screening Analysis of Proteolytic Enzymes and Their Inhibitors in the Leaflets of Epoxy-Treated Bioprosthetic Heart Valves Explanted due to Dysfunction
Bioprosthetic heart valves (BHVs) have lower thrombogenicity rates and excellent hemodynamic parameters similar to native ...
Clinical and Diagnostic Significance of Sialic Acids Determination in Biological Material
Clinical and Diagnostic Significance of Sialic Acids Determination in Biological Material
Sialic acids (SA) are neuraminic acid derivatives, located at the terminal position in the chains of monosaccharide residu...
Influence of N-Alkynylaminosteroids on Mitochondrial Functioning and Autophagy in Glioma Cells
Influence of N-Alkynylaminosteroids on Mitochondrial Functioning and Autophagy in Glioma Cells
The effect of the synthesized N-alkynyl-17-aminosteroids and N-alkynyl-20-aminosteroids (based on dehydroepiandrosterone a...
Increased Suppressor Activity of Ex Vivo Transformed Regulatory T Cells in Comparison with Unstimulated Cells of the Same Donor
Increased Suppressor Activity of Ex Vivo Transformed Regulatory T Cells in Comparison with Unstimulated Cells of the Same Donor
Regulatory T cells CD4+CD25+FoxP3+СD127low (Tregs) play a key role in the maintenance of tolerance to autoantigens, ...
Expression Levels and Activity of Rat Liver Lactate Dehydrogenase Isoenzymes in Alloxan Diabetes
Expression Levels and Activity of Rat Liver Lactate Dehydrogenase Isoenzymes in Alloxan Diabetes
A significant decrease in the activity of liver lactate dehydrogenase (LDH, EC 1.1.1.27) associated with a decrease in the...
Lipidomic Markers of Tumor Progress in Breast Cancer Patients
Lipidomic Markers of Tumor Progress in Breast Cancer Patients
Research of cancer progression mechanisms and their impact on metabolism of tumor cells and tumor microenvironment cells i...
Production and Internalization of Extracellular Vesicles in Norm and under Conditions of Hyperglycemia and Insulin Resistance
Production and Internalization of Extracellular Vesicles in Norm and under Conditions of Hyperglycemia and Insulin Resistance
Extracellular vesicles (EVs) are spherical functionally important structures of cell membrane origin ranging in size from ...
Determination of the Risk of Tumor Progression in Patients with Early Stages of Adenocarcinoma and Squamous Cell Lung Carcinoma Based on Laboratory Parameters
Determination of the Risk of Tumor Progression in Patients with Early Stages of Adenocarcinoma and Squamous Cell Lung Carcinoma Based on Laboratory Parameters
Non-small cell lung cancer (NSCLC) dominates in the morbidity of lung cancer. In stage I, only 60–70% patients overc...
Prenatal Exposure to Alcohol Alters TLR4 Mediated Signaling in the Prefrontal Cortex in Rats
Prenatal Exposure to Alcohol Alters TLR4 Mediated Signaling in the Prefrontal Cortex in Rats
Prenatal alcohol exposure (PAE) can lead to developmental disorders of the central nervous system (CNS) and mental retarda...
Pregnan X Receptor Functioning under Conditions of Nitrosative Stress
Pregnan X Receptor Functioning under Conditions of Nitrosative Stress
Pregnan X receptor (PXR) is a nuclear receptor that plays an important role in the regulation of the expression enzymes of...
The Effect of Methylene Blue and Its Metabolite—Azure I—on Bioenergetic Parameters of Intact Mouse Brain Mitochondria
The Effect of Methylene Blue and Its Metabolite—Azure I—on Bioenergetic Parameters of Intact Mouse Brain Mitochondria
Methylene blue, a phenothiazine dye, that is widely used in medicine and is under clinical trials as an agent for treatmen...
The Effect of Lipid Derivative of the Anti-Tumor Drug Sarcolysin Embedded in Phospholipid Nanoparticles in the Experiments in Vivo
The Effect of Lipid Derivative of the Anti-Tumor Drug Sarcolysin Embedded in Phospholipid Nanoparticles in the Experiments in Vivo
In order to improve the therapeutic properties of the antitumor agent sarcolysin, we have previously developed and charact...
The Bioinformatic Identification of Proteins with Varying Levels of Post-Translational Modifications in Experimental Ischemic Stroke in Mice
The Bioinformatic Identification of Proteins with Varying Levels of Post-Translational Modifications in Experimental Ischemic Stroke in Mice
The experimental data obtained by Simats, A. et al. (Molecular and Cellular Proteomics, 2020, vol. 19, no. 12, pp...
Cysteine Cathepsins: Structure, Physiological Functions, and the Role in Carcinogenesis
Cysteine Cathepsins: Structure, Physiological Functions, and the Role in Carcinogenesis
Cysteine cathepsins (Cts) also known as thiol proteinases belong to the superfamily of cysteine proteinases. Most Cts are ...
Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium
Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium
The review summarizes literature data on molecular and biochemical mechanisms of nonspecific protection of respiratory epi...
PCR Analysis of the Expression of Chromosome 18 Genes in Human Liver Tissue: Interindividual Variability
PCR Analysis of the Expression of Chromosome 18 Genes in Human Liver Tissue: Interindividual Variability
Using human chromosome 18 (Ch18) genes as an example, a PCR analysis of the interindividual variability of expression of 2...
Neurotransmitter Impairments in the Brain Induced by Acute Combined Intoxication of Rats with Ethanol and Morphine
Neurotransmitter Impairments in the Brain Induced by Acute Combined Intoxication of Rats with Ethanol and Morphine
The levels of biogenic monoamines and their metabolites have been investigated in the hypothalamus, midbrain, and cerebell...
The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy
The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy
In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of...
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