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Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
When developing vaccines and immunotherapeutic and enzymatic drugs, it is usually necessary to obtain a functional protein...
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
Dyslipidemia is a well-known risk factor for the development of cardiovascular diseases and atherosclerosis. The effects o...
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
Arachidonic acid (AA) is widely distributed in many organs and can be metabolized in several ways into small lipid molecul...
Effects of Various Poly(A) Tails on Luciferase Expression
Effects of Various Poly(A) Tails on Luciferase Expression
Synthesis of RNA by in vitro transcription has many applications in the production of vaccines, anticancer and gene therap...
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
The development of effective delivery systems for antitumor drugs with increased specificity and controlled release is one...
Expression of miR-21, miR-378a, miR-205, and Their Targets in ER-Positive Breast Tumors with Different HER2 Protein Levels
Expression of miR-21, miR-378a, miR-205, and Their Targets in ER-Positive Breast Tumors with Different HER2 Protein Levels
Tyrosine protein kinase HER2 plays an important role in carcinogenesis. In breast cancer (BC), the HER2 gene is amplified ...
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation
The authors examined 111 practically healthy individuals (66 women and 45 men aged 46–55 years) living and working i...
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
Adaptation and Experimental Validation of Clinical RNA Sequencing Protocol Oncobox for MGI DNBSEQ-G50 Platform
RNA sequencing (RNAseq) is currently a method of choice for the high-throughput RNA-level analysis of gene expression. Fur...
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A New Human Uveal Melanoma Cell Line: Melanin Production and Molecular Markers for Targeted Therapy
A new human uveal melanoma (UM) cell line uMel1 was established by mechanical disintegration of a tumor fragment. uMel1 ce...
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
The study compared the content of IgG specific to 90 food antigens in practically healthy people and in people with metabo...
Glycation and Glucose Variability in Subjects with Type 1 Diabetes
Glycation and Glucose Variability in Subjects with Type 1 Diabetes
High glucose variability (GV) and increased glycation may play a role in the development of diabetes complications. We aim...
Investigating the Role of KLF6-SV1 as a Regulator of EMT Progression
Investigating the Role of KLF6-SV1 as a Regulator of EMT Progression
Post-translational modifications (PTMs) are crucial for all biological processes and offer insights into protein functions...
Investigation of the Several Aspects of Interaction between Human Serum Albumin and Oleic Acid by Molecular Dynamic Simulation Approaches and Spectroscopic Methods
Investigation of the Several Aspects of Interaction between Human Serum Albumin and Oleic Acid by Molecular Dynamic Simulation Approaches and Spectroscopic Methods
The most predominant fatty acid in olive oil, oleic acid (OA), lowers LDL (low-density lipoprotein) cholesterol and may ra...
Synthesis, Spectral, and Structural Investigations and Anticancer Activity In Vitro of the New Organotin Complexes
Synthesis, Spectral, and Structural Investigations and Anticancer Activity In Vitro of the New Organotin Complexes
The series of new organotin complexes on the basis of bis(trimethylsilylmethyl)tin diсhloride, 1,1-dichloro-1-stanna...
Medicinal Applications and Prospects of Tetra- and Tripyrrole Compounds
Medicinal Applications and Prospects of Tetra- and Tripyrrole Compounds
This review is devoted to some areas of medicinal application of pyrrole-containing macroheterocycles. Two main applicatio...
Deep Learning Methods for Binding Site Prediction in Protein Structures
Deep Learning Methods for Binding Site Prediction in Protein Structures
This work is an overview of deep machine learning methods aimed at predicting binding sites in protein structures. Several...
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Melanoma is one of the most aggressive types of cancer. Melanoma morbidity is increasing every year and mortality rate is ...
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Mast cells (MCs) are an important population of connective tissue cells that play a key role in the development of allergi...
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Different efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been observed between lun...
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
Many disorders can be accurately diagnosed using ribonucleic acids (RNAs). A panel of RNAs specific to colorectal cancer (...
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
The processes of progressive decrease in muscle mass and weakening of mitochondrial function that occur during aging in sk...
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Background: This study assessed the association of vitamin D status with the frequency of incidence of metabolic health ri...
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
The E3 ubiquitin ligase Cullin 5 (CUL5) has been linked to a variety of cell biological functions, such as developmental p...
Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection
The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α1-proteinase inhibitor (α1...
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets
G-quadruplexes (G4), non-canonical secondary DNA structures, have been intensively investigated for a long time. In eukary...
Effect of Ethanol on Platelet Biology
Effect of Ethanol on Platelet Biology
In recent years, there has been interest in the study of platelets, the functions of which, as it turned out, are not limi...
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems
Antioxidant and anti-ischemic properties of the pharmacological agonist of galanin receptor GalR2 WTLNSAGYLLGPβAH (Ga...
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line
The analysis of cytochrome P450 transcripts was carried out by the nanopore sequencing in liver tissue samples of three do...
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome
Some brain-derived neurotrophic factor (BDNF)-targeted miRNAs such as miR-30a-5p may be associated with alcohol addiction;...
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9)
We studied the interaction of the antitumor agent abiraterone and its pharmacologically active metabolite D4A, which is pr...
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