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Managing Rheumatoid Arthritis in Older Adults with Cancer
Managing Rheumatoid Arthritis in Older Adults with Cancer
Rheumatoid arthritis (RA) is a chronic autoimmune condition disproportionately affecting older adults (> 60 years),...
Aging in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: From Pathophysiology to Clinical Management
Aging in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: From Pathophysiology to Clinical Management
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) predominantly affect individuals aged 55–75...
Burden of Disease and Treatment Gap in Patients with an Osteoporotic Hip Fracture between 2015 and 2019 in Italy
Burden of Disease and Treatment Gap in Patients with an Osteoporotic Hip Fracture between 2015 and 2019 in Italy
Osteoporosis (OP) represents a public health challenge, with OP fractures associated with high morbidity, mortality, and e...
Metformin: An Old Drug with New Tricks—Promising Role in Vascular Aging and Cardioprotection
Metformin: An Old Drug with New Tricks—Promising Role in Vascular Aging and Cardioprotection
Metformin, traditionally promoted for its efficacy in diabetes, is increasingly appreciated for its geroprotective potenti...
Real-World Harm Reduction of Metformin Plus DPP4 Inhibitors versus Metformin Plus Sulfonylureas in Older Adults: A Target Trial Emulation Using German Claims Data
Real-World Harm Reduction of Metformin Plus DPP4 Inhibitors versus Metformin Plus Sulfonylureas in Older Adults: A Target Trial Emulation Using German Claims Data
This study complements evidence from randomized controlled trials on the harms (e.g., hypoglycemia) of sulfonylureas compa...
Scabies in older adults: What Is New in Diagnosis and Treatment?
Scabies in older adults: What Is New in Diagnosis and Treatment?
Scabies is a common and disabling ectoparasitic infestation of the skin that can clinically present in ‘classical...
Drugs and Healthy Aging
Drugs and Healthy Aging
Appropriate drug treatment can enhance the likelihood of experiencing healthy aging and maintaining functional ability up ...
Incontinence-Associated Dermatitis in Older Adults: A Critical Review of Risk Factors, Prevention and Management
Incontinence-Associated Dermatitis in Older Adults: A Critical Review of Risk Factors, Prevention and Management
Prolonged and repeated exposure of the skin to urine and/or faeces may lead to incontinence-associated dermatitis (IAD). I...
One-Year Mortality in Hospitalized, Frail Older Adults with Atrial Fibrillation on Oral Anticoagulant Therapy: Impact of Stroke and Bleeding Events
One-Year Mortality in Hospitalized, Frail Older Adults with Atrial Fibrillation on Oral Anticoagulant Therapy: Impact of Stroke and Bleeding Events
Atrial fibrillation (AF) is common in older adults, and anticoagulation is recommended for those aged 75 years and older. ...
Pain in Osteoporosis: Current and Future Strategies
Pain in Osteoporosis: Current and Future Strategies
Osteoporosis is the most common metabolic bone disease and the main cause of fractures in older adults. Although it is com...
Efficacy and Tolerability of Vortioxetine Versus Selective Serotonin Reuptake Inhibitors for Late-Life Depression: A Post-hoc Analysis of the VESPA Study
Efficacy and Tolerability of Vortioxetine Versus Selective Serotonin Reuptake Inhibitors for Late-Life Depression: A Post-hoc Analysis of the VESPA Study
Usual treatment approaches for late-life depression primarily involve selective serotonin reuptake inhibitors (SSRIs). Rec...
Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients
Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients
Apixaban is the most prescribed direct-acting oral anticoagulant drug. According to its product information, clearance is ...
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Older inpatients with dementia are at an increased risk of an adverse drug reaction (ADR) during hospitalization. To quant...
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Corticosteroids play a crucial role as anti-inflammatory and immunomodulatory agents in dermatology and other medical spec...
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
As dementia progresses, people living with dementia may take high-risk, unnecessary, or ineffective medicines. Cholinester...
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Steroids are widely used in maintenance immunosuppression treatment in kidney transplant recipients. Older individuals und...
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Approximately one in three older adults (aged 65 years and over) experience pain, negatively impacting their quality of li...
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Presbyopia is a common age-related visual impairment. With the aging of the population, the incidence of presbyopia is inc...
Pharmacological Treatment of Obesity in Older Adults
Pharmacological Treatment of Obesity in Older Adults
Obesity is a complex health issue with growing prevalence worldwide. It is also becoming more prevalent in the population ...
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Frailty is associated with increased susceptibility to medication-related harm, highlighting the importance of medication ...
Assessing Frailty-Specific Treatment Effect in Cardiovascular Disease: A Systematic Review
Assessing Frailty-Specific Treatment Effect in Cardiovascular Disease: A Systematic Review
Clinicians are increasingly considering using frailty assessments to individualize treatment for older patients. It remain...
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study
Despite growing awareness of sex differences in inappropriate prescribing among older adults, including the initiation of ...
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Postoperative delirium (POD) is a common complication in older adult patients after surgery. A patient’s preoperativ...
Relationship Between Frailty and Diabetic Pharmacologic Therapy in Older Adults with Type 2 Diabetes: A Cross-Sectional Study
Relationship Between Frailty and Diabetic Pharmacologic Therapy in Older Adults with Type 2 Diabetes: A Cross-Sectional Study
Older adults with diabetes mellitus require drug treatment considering their frailty, cognitive function, and hypoglycemia...
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
Although gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longe...
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
Although gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longe...
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Surgeons have come under increased scrutiny for postoperative pain management, particularly for opioid prescribing. To dec...
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Surgeons have come under increased scrutiny for postoperative pain management, particularly for opioid prescribing. To dec...
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
The aim was to evaluate prevalence and factors associated with anti-tumor necrosis factor (anti-TNF) de-escalation in olde...
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
The aim was to evaluate prevalence and factors associated with anti-tumor necrosis factor (anti-TNF) de-escalation in olde...
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