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Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Cenobamate is an antiseizure medication (ASM) approved in the US and Europe for the treatment of uncontrolled focal seizur...
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
The number of older individuals receiving a kidney transplant as replacement therapy has significantly increased in the pa...
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
Pain and frailty are closely linked. Chronic pain is a risk factor for frailty, and frailty is a risk factor for pain. Peo...
Proton Pump Inhibitor Use and the Risk of Cardiovascular Complications and Death in Older Adults with Diabetes: A Population-Based Cohort Study
Proton Pump Inhibitor Use and the Risk of Cardiovascular Complications and Death in Older Adults with Diabetes: A Population-Based Cohort Study
The unfavorable effect of proton pump inhibitors (PPIs) on cardiovascular (CV) outcomes and mortality was reported in the ...
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review
Suboptimal prescribing, including the prescription of potentially inappropriate medications (PIM), is frequent in patients...
Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma
Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma
Older patients are often underrepresented in clinical trials owing to exclusionary comorbidities, which are more common wi...
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Cannabis use is increasing among older adults, with use primarily for medicinal purposes. Much of the evidence on percepti...
Management of Scleritis in Older Adults
Management of Scleritis in Older Adults
Scleritis, an inflammatory disease of the eye affecting scleral tissue, presents unique challenges in the older adult popu...
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties....
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Osteoarthritis (OA) is a major cause of chronic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are analgesics common...
Post-Stroke Depression in Older Adults: An Overview
Post-Stroke Depression in Older Adults: An Overview
Detailed data on post-stroke depression (PSD) in older adults are limited in spite of the high vulnerability of this popul...
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Statins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscula...
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Preliminary evidence suggests a possible preventive effect of tumor necrosis factor-α inhibitors (TNFi) on incident d...
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea is a chronic inflammatory skin condition that is often more severe in older patients. The main clinical features a...
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Physicians often face difficulties in selecting appropriate medications for older adults with multiple comorbidities. As p...
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Though more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythemato...
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management mode...
Evaluating the Safety of an Educational Deprescribing Intervention: Lessons from the Optimize Trial
Evaluating the Safety of an Educational Deprescribing Intervention: Lessons from the Optimize Trial
Patients, family members, and clinicians express concerns about potential adverse drug withdrawal events (ADWEs) following...
Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis
Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis
Polypharmacy in multimorbid older patients with atrial fibrillation (AF) is a risk factor for potentially inappropriate pr...
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients
Spondylarthritis (SpA) is generally observed in young male patients but can be diagnosed in older patients. These cases co...
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study
Polypharmacy is common in older adults, particularly among those living in long-term care facilities. This condition repre...
Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study
Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study
Atrial fibrillation (AF) is a common condition among older adults, requiring anticoagulation therapy to prevent thromboemb...
Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis
Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis
There has been considerable focus on the use of psychotropic agents in people living with dementia in long-term care. Howe...
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review
Hip fracture (HF) mostly affects older adults and is responsible for increased morbidity and mortality. Non-steroidal anti...
Five-Year Follow-Up of Diabetic Complications and Geriatric Alterations in French Older Patients with Type 2 Diabetes According to Treatment Modalities: The Observational Prospective GERODIAB Cohort
Five-Year Follow-Up of Diabetic Complications and Geriatric Alterations in French Older Patients with Type 2 Diabetes According to Treatment Modalities: The Observational Prospective GERODIAB Cohort
Little is known about clinical events occurring in older patients with type 2 diabetes mellitus according to their therape...
Low-Income Older Adults’ Vulnerability to Anticholinergic Medication-Associated Frailty
Low-Income Older Adults’ Vulnerability to Anticholinergic Medication-Associated Frailty
A growing body of research supports the negative impact of anticholinergic drug burden on physical frailty. However, prior...
Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review
Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review
To reduce prescribing cascades occurring in clinical practice, healthcare providers require information on the prescribing...
Anti-VEGF Drugs in Age-Related Macular Degeneration: A Focus on Dosing Regimen-Related Safety and Efficacy
Anti-VEGF Drugs in Age-Related Macular Degeneration: A Focus on Dosing Regimen-Related Safety and Efficacy
Age-related macular degeneration (AMD) is one of the main causes of visual impairment and severe visual loss, and can prog...
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis
Older adults are at an increased risk of drug-related problems, especially following discharge from hospital. Drug-related...
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing
Opioids and benzodiazepines (BZDs) pose a public health problem. Older adults are especially susceptible to adverse events...
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