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Molybdenum-Catalyzed Deoxygenative Heterocyclization of 2-Nitroazobenzenes: A Novel Strategy for Catalytic Synthesis of 2-Aryl-2H-benzo[d][1,2,3]triazoles
A novel strategy for catalytic synthesis of 2-aryl-2H-benzo[d][1,2,3]triazoles by non-noble molybdenum-catalyzed deoxygena...
Non-enzymatic Synthesis of C-Methylated Fluostatins: Discovery and Reaction Mechanism
Two methylation FSTs, FST B3/FST B4 (1/2), were obtained from oxidative ring-opening reaction. The structure of 1/2 were e...
Oxidative cascade cyclization of N-arylacrylamides with TMSN3
An azido-radical-triggered cyclization of N-(o-cyanobiaryl)acrylamides with TMSN3 via a C(sp3)–N/C(sp2)–C(sp3)/C(sp2)–N bo...
Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes
A highly effective and selective FeBr3 promoted deuterium bromination/cyclization of 1,n-enynes is reported. On one hand, ...
Practical and scalable enantioselective synthesis of (+)-majoranolide from Cyrene
A two-step enantioselective gram scale synthesis of the Persea derived γ-lactones (+)-majoranolide and (+)-majoranolide B ...
A transition-metal-free azide-alkyne cycloaddition / hydroamination cascade reaction for the construction of triazole-fused piperazin-2-ones
A time-dependent, divergent synthesis of highly functionalized [1,2,3]triazolo[1,5-a]pyrazin-4(5H)-one (reaction time: 12 ...
Visible-light-induced decarboxylative cascade cyclization of acryloylbenzamides with N-hydroxyphthalimide esters via EDA complexes
Visible-light-induced decarboxylative cascade reactions of acryloylbenzamides with alkyl N-hydroxyphthalimide (NHP) esters...
Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds
Benzopyrans (BZPs) are one of the most privileged and influential small O-heterocycles that form the core of many natural ...
Iridium (III)-Catalyzed β-Trifluoromethyl Enone Carbonyl Directed Regio-Selective C(sp2)-H Olefination
Due to the lower LUMO energy level at β-position of α,β-unsaturated-β-trifluoromethyl enone than its non-fluorinated count...
Selective α-oxidation of amides via visible-light-driven Iron-catalysis
The hydroxyl radical (•OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. T...
Direct Synthesis of Phenanthrenyl Triflates from 1-Biphenylyl-2-diazo-2-aryl Ketones and Triflic Anhydride
A strategy for direct synthesis of phenanthrenyl triflates from 1-biphenylyl-2-diazo-2-aryl ketones and triflic anhydride ...
Synthesis of 4-Sulfonyl-1,7-diesters via K2CO3-Mediated Alkylative Debenzoylation of α-Sulfonyl o-Hydroxyacetophenones with Acrylates
The synthesis of 4-sulfonyl-1,7-diesters was well-developed, under the open-vessel condition, by K2CO3-mediated double alk...
Brønsted Acid and Ni(II)-catalyzed C-H Oxidation/Rearrangement of Cyclotriveratrylenes (CTVs) to Cyclic and Acyclic Quinones as Potential Anti-cancer Agents
This paper describes a simple and practical protocol for the direct synthesis of acyclic and cyclic quinone derivatives vi...
Asymmetric synthesis of (R)-baclofen and (3S,4S)-tetflupyrolimet via “on water” organocatalytic addition reactions: a tip on catalysts screening
This work demonstrated asymmetric synthesis of GABA derivative (R)-baclofen and a new herbicidal mode-of-action inhibitor ...
Metal‑ and Base-Free, Aerobic Photoredox Catalysis with Riboflavin to Synthesize 2-Substituted Benzothiazoles
Sustainable approaches for the synthesis of 2-substituted benzothiazoles are sought after for their use in organic chemist...
5-exo-Selective Asymmetric Bromolactonization of Stilbenecarboxylic Acids Catalyzed by Phenol-bearing Chiral Thiourea
We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5-exo-bromolactonization o...
Electrochemical oxidative dehydrogenative annulation of 1-(2-aminophenyl)pyrroles with cleavage of ethers to synthesize pyrrolo[1,2-a]quinoxaline derivatives
An array of pyrrolo[1,2-a]quinoxaline derivatives were achieved with moderate to good yields via the electrochemical redox...
Efficient Amidation of Weak Amine: Synthesis, Chiral Separation by SFC, and Antimicrobial Activity of N-(9, 10-dioxo-9, 10-dihydro anthracene-1-yl) carboxamide
An effective and straight forward method for the synthesis of 1-aminoanthracene-9,10-dione carboxamides, by coupling weakl...
Synthesis of Sulfinamides via Photocatalytic Alkylation or Arylation of Sulfinylamine with Potassium Trifluoro(organo)borates
Sulfinamides are a versatile class of compounds that find applications in both organic synthesis and pharmaceuticals. Here...
Synthesis of Cs-symmetrical C60 tetra-adducts via reactions of C60Cl6 with CH-acids and enol silyl ester
Here we report the synthesis of novel fullerene derivatives with attached aliphatic residues based on the previously unkno...
Two Distinct Protocols for the Synthesis of Unsymmetrical 3,4-Disubstituted Maleimides Based on Transition-Metal Catalysts
Two tandem catalytic systems are described for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi addu...
PCy3 assisted Ag(I) catalyzed click reaction for regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature
An approach towards Cu-free click chemistry has been reported in this work. Silver catalyzed PCy3 ligand assisted 1,4-disu...
Synthesis of mixed Phosphorotrithiotes via coupling of Thiol with Bis(diisopropylamino)chlorophosphine and Sulphenyl Chloride
In this study, we report a novel and efficient one-pot synthesis of mixed phosphorotrithioates under mild conditions at am...
Copper-mediated [3+2] oxidative cyclization of oxime acetate and their utility in formal synthesis of fentiazac
A new protocol for the direct synthesis of 2-aminothiazole has been developed from oxime acetate and readily available sod...
Developing a Straightforward Route Toward Synthesis of Arylaminomaleimides by Palladium-Catalyzed Arylation of One-Pot Synthesized Aminomaleimides
3-Aryl-4-aminomaleimides have well-demonstrated applications, such as use as fluorophores and inhibitors. However, their p...
Synthesis of benzimidazole-fused 1,4-benzoxazepines and benzosultams spiro-connected to a 2-oxindole core via a tandem epoxide-opening/SNAr approach
While hundreds of literature reports describe the preparation of spirooxindole-based 5- and 6-membered-heterocycles, const...
Theoretical Investigation of Tautomerism of 2- and 4-Pyridones: Origin, Substituent and Solvent Effects
Computational investigation at the BHandHLYP/6-311G(d,p) level of theory of the gas-phase tautomerism of 2- and 4-pyridon...
Molecular clips with spatially proximal urea residues for efficient transmembrane co-transport of H+/Cl− ions
We report the design of bis(urea) functionalized amphiphilic molecular clips, viz. 1a-1e to achieve efficient transmembran...
Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation / Houben-Hoesch cyclization 2-step sequence
In this manuscript we report the efficient and selective two-step synthesis of various 3-silyl-2-amidoindenones from easil...
Catalyst-Free Assembly of Poly-Functionalized 1,2,4-Triazole-Fused N-Heterocycle, 6-Acylated Pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine
A catalyst-free synthetic route to a new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]t...
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