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Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway
Chronic pancreatitis (CP) is a progressive disease characterized by injury on pancreatic acinar cells (PACs), ongoing fibr...
Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes
Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes
Actinomycetes have produced a variety of bioactive secondary metabolites; however, discovering new actinobacterial natural...
Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics
Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics
In this study, a lipid disorder Alzheimer’s disease (AD) model was developed with high-fat diet and d-galac...
Tenacissoside G reverses paclitaxel resistance by inhibiting Src/PTN/P-gp signaling axis activation in ovarian cancer cells
Tenacissoside G reverses paclitaxel resistance by inhibiting Src/PTN/P-gp signaling axis activation in ovarian cancer cells
Ovarian cancer (OC) is the most common malignant gynecologic tumor, with the highest mortality rate among female reproduct...
Insight of action mechanism of Astragaloside IV for relieving of cerebral ischemic injury in a rat model of middle cerebral artery occlusion reperfusion via proteomics and network pharmacology
Insight of action mechanism of Astragaloside IV for relieving of cerebral ischemic injury in a rat model of middle cerebral artery occlusion reperfusion via proteomics and network pharmacology
Astragaloside IV (AS-IV) is the principal active component of Astragalus membranaceus (fisch.) Bge. var. mongholicus (Bge....
Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases
Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases
The increasing prevalence of obesity and its related diseases, including diabetes mellitus and metabolic dysfunction-assoc...
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway
Dendrobium huoshanense has received special attention for its advantages in the treatment of lung cancer, but the underlyi...
Exploring anti-hyperglycemic potential of isolation, structural elucidation and -glucosidase inhibition evaluation
Exploring anti-hyperglycemic potential of isolation, structural elucidation and -glucosidase inhibition evaluation
Pseuderanthemum crenulatum (Acanthaceae) is a medicinal plant traditionally used to manage diabetes. However, its chemical...
Natural products that target p53 for cancer therapy
Natural products that target p53 for cancer therapy
Wild-type p53 acts as a tumor suppressor, but p53 is frequently mutated and inactivated in tumor cells, promoting cancer p...
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis
This study aimed to investigate the effects of astragaloside IV(AS-IV) and quercetin (QCT) on autophagic activity, pyropto...
Identification of specialized metabolites from as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study
Identification of specialized metabolites from as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study
Artocarpus species play an important role in the folk medicine of various ethnic groups in Africa, South Asia, and Southea...
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells
Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells
The application of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) holds significant promise in anti-agin...
Amyloid-β aggregation inhibitory activity of triterpene saponins from the cactus
Amyloid-β aggregation inhibitory activity of triterpene saponins from the cactus
Seven new triterpene saponins (1–7) and two known saponins (8, 9) were isolated from MeOH extracts of Stenocereus gu...
Chlorinated illudalane sequiterpenoids from
Chlorinated illudalane sequiterpenoids from
Eight chlorinated illudalane sesquiterpenoids were isolated from the aerial parts of Saxiglossum angustissimum, including ...
Loganin ameliorates left ventricular fibrosis and dysfunction induced by pressure overload via the Sirt1/AKT/TGF-β1 signaling pathway
Loganin ameliorates left ventricular fibrosis and dysfunction induced by pressure overload via the Sirt1/AKT/TGF-β1 signaling pathway
Loganin (LG), a natural compound derived from Cornus officinalis Sieb. et Zucc., possesses diverse pharmacological propert...
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca/NOX2/NF-κB signaling pathways
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca/NOX2/NF-κB signaling pathways
Ginsenoside Rh3, a bioactive component of ginsenosides, has gained attention for its potential therapeutic effects, especi...
Safranal ameliorates atherosclerosis progression partly via repressing PI3K/Akt and NF-κB signaling pathways in ApoE (−/−) mice
Safranal ameliorates atherosclerosis progression partly via repressing PI3K/Akt and NF-κB signaling pathways in ApoE (−/−) mice
Atherosclerosis (AS) remains the main cause of vascular diseases. This study reveals the effects of safranal and underlyin...
A plasma metabolomic analysis revealed the metabolic regulatory mechanism of the water extract of in improving streptozotocin-induced type 1 diabetes model rats
A plasma metabolomic analysis revealed the metabolic regulatory mechanism of the water extract of in improving streptozotocin-induced type 1 diabetes model rats
D. huoshanense is a traditional Chinese medicine with antidiabetes effects, but the underlying metabolic regulatory mechan...
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type ses...
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Menthae Herba is an herbal medicine whose name is written with the same kanji characters (薄荷) in both the Ja...
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Previously, we reported that azamollugin, an aza-derivative of mollugin, exhibited potent inhibitory activity on NO produc...
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Lysiphyllum binatum (Blanco) de Wit in the Fabaceae family, despite its traditional medicinal uses, has not been the subje...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for ...
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape ...
New sesquiterpenes from the soft coral Litophyton arboreum
New sesquiterpenes from the soft coral Litophyton arboreum
Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in...
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition...
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