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Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7
The Wnt/β-catenin signaling pathway plays important roles in several cancer cells, including cell proliferation and d...
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability
Chemotherapy is still a prevalent strategy for clinical lung cancer treatment. However, the inevitable emerged drug resist...
Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury
Kaempferol-3-O-(2″-O-galloyl-β-d-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia—induced brain injury
Our previous study demonstrated neuroprotective and therapeutic effects of a standardized flavonoid extract from leaves of...
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity
Identification of intracellular activation mechanism of rhamnogalacturonan-I type polysaccharide purified from Panax ginseng leaves in macrophages and roles of component sugar chains on activity
This study aimed to investigate the mechanisms underlying intracellular signaling pathways in macrophages in relation to t...
Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs
Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs
Our representative studies to achieve sustainable use of crude drugs and ensure their stable quality are introduced: compr...
Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus
Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatric...
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway
Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway
Angelica dahurica (A. dahurica) has a wide range of pharmacological effects, including analgesic, anti-inflammatory and he...
Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo
Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo
Dihydroartemisinin (DHA), a derivative of artemisinin which is primarily used to treat malaria in clinic, also confers pro...
Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentrax...
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse
The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse
Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis l...
Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural
Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural
Gentianae Radix, an herbal medicine, has been used as a gastrointestinal drug in Japan. In the Japanese Pharmacopoeia 18th...
Recent trends in ginseng research
Recent trends in ginseng research
Ginseng, the dried root of Panax ginseng, contains ginsenosides and has long been used in Korea, China, and Japan to treat...
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro
Papain-like protease (PLpro) enzyme plays a vital role in viral replication as it breaks down polyproteins and disrupts th...
Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex
Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex
Photochemical reactions are powerful tools for synthesizing organic molecules. The input of energy provided by light offer...
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of a new 3,4-seco-isopimarane dit...
Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss
Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss
A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, w...
Non-enzymatic reactions in biogenesis of fungal natural products
Non-enzymatic reactions in biogenesis of fungal natural products
Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. ...
Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis
Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis
Osteoporosis (OP) is closely related to iron overload. Bajitianwan (BJTW) is a traditional Chinese medicine formulation us...
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
Recently, the number of patients diagnosed with dementia has increased. The World Health Organization (WHO) estimates that...
Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
The impact of hypertension on tissue and organ damage is mediated through its influence on the structure and function of b...
Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors
Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors
Chrysin (5,7-dihydroxyflavone, 6) and galangin 3-methyl ether (5,7-dihydroxy-3-methoxy flavone, 7) were obtained from the ...
Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors
Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors
The Japanese herbal medicine kamikihito (KKT) is widely used for insomnia, anorexia, anemia, and depression. Recently, the...
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells
The hypothalamic–pituitary–adrenal (HPA) system plays an important role in stress response. Chronic stress is ...
Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes
Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes
Epoxides, aziridines, and cyclopropanes are found in various medicinal natural products, including polyketides, terpenes, ...
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver
An acylated flavonol glycoside, trans-tiliroside (1), is found in certain parts of different herbs, including the seeds of...
The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome
The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome
Citrinin derivatives have been found to have various pharmacological activities, such as anti-inflammatory, anti-tumor, an...
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Controlling and treating biofilm-related infections is challenging because of the widespread presence of multidrug-resista...
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Fibroblast growth factor 21 (FGF21) is expressed in several organs, including the liver, adipose tissue, and cardiovascula...
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation
Hepatocellular carcinoma (HCC) treatment is a major challenge. Although andrographolide (Andro) has an anti-proliferation ...
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway
Cancer stem cells (CSCs) are the primary source of tumor recurrence and chemoresistance, which complicates tumor treatment...
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