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Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type ses...
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Menthae Herba is an herbal medicine whose name is written with the same kanji characters (薄荷) in both the Ja...
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Previously, we reported that azamollugin, an aza-derivative of mollugin, exhibited potent inhibitory activity on NO produc...
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Lysiphyllum binatum (Blanco) de Wit in the Fabaceae family, despite its traditional medicinal uses, has not been the subje...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for ...
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape ...
New sesquiterpenes from the soft coral Litophyton arboreum
New sesquiterpenes from the soft coral Litophyton arboreum
Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in...
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition...
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Acacia confusa Merr. (Fabaceae) (A. confusa) is a native tree species of Taiwan, commonly found in the low-altitude mounta...
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
Inflammation is a vital and normal physiological response; however, excessive inflammation can contribute to the ...
Proposal for structure revision of pinofuranoxin A through total syntheses of stereoisomers
Proposal for structure revision of pinofuranoxin A through total syntheses of stereoisomers
The relative configuration of the epoxide functionality in pinofuranoxin A (1), α-alkylidene-β-hydroxy-γ-me...
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obes...
Evaluation of Rhododendri Mollis Flos and its representative component as a potential analgesic
Evaluation of Rhododendri Mollis Flos and its representative component as a potential analgesic
Rhododendri Mollis Flos (R. mole Flos), the dried flowers of Rhododendron mole G. Don, have the ability to relieve pain, d...
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV–XVII
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV–XVII
Ipomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins...
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlyi...
A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism
A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism
A combination of LC–MS/MS and feature-based molecular networking analyses led to the isolation of a new adenopeptin ...
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption
Mountain caviar is a fruit of Kochia scoparia that contains momordin Ic as a major saponin constituent. Its extract (MCE) ...
Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports
Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports
Recently, health hazards, such as kidney damage, have been reported owing to the ingestion of a health food product, so-ca...
Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway
Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway
Urolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and urolithin B (UB) were...
Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation
Di-caffeoylquinic acid: a potential inhibitor for amyloid-beta aggregation
Alzheimer's disease (AD) remains a challenging neurodegenerative disorder with limited therapeutic success. Traditiona...
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
A phytochemical investigation of Kaempferia champasakensis rhizomes led to the isolation of five new pimarane diterpenes, ...
Dragon’s blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways
Dragon’s blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways
Inflammation-induced intestinal epithelial barrier (IEB) dysfunction is one of the important reasons for the occurrence an...
Search for new steroidal glycosides with anti-cancer potential from natural resources
Search for new steroidal glycosides with anti-cancer potential from natural resources
Chemical investigations of higher plants, with particular attention paid to their steroidal glycosides, present a promisin...
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7
Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7
The Wnt/β-catenin signaling pathway plays important roles in several cancer cells, including cell proliferation and d...
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability
Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability
Chemotherapy is still a prevalent strategy for clinical lung cancer treatment. However, the inevitable emerged drug resist...
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