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Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
IntroductionBoth rheumatic musculoskeletal diseases (RMDs) and cancer occur frequently in the general population and these...
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
WHAT IS KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis study shows that the death of intestinal epithelial cells via necropto...
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
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Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
IntroductionSerological activity in systemic lupus erythematosus (SLE) generally refers to the presence of anti-dsDNA anti...
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
IntroductionSystemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients experience diverse organ ...
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
IntroductionOsteoarthritis is a highly complex disease that poses a significant burden on both individuals and society due...
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
AbstractObjectives Inflammatory cytokines that signal through the Janus kinases–signal transducer and activator of transcr...
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
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Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
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An ulcerating skin tumour in a patient with rheumatoid arthritis
An ulcerating skin tumour in a patient with rheumatoid arthritis
A 78-year-old white woman was diagnosed in 2010 with IgM-rheumatoid factor negative, anticyclic citrullinated peptide-posi...
Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients
Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients
WHAT IS ALREADY KNOWN ON THIS TOPICIn April 2020, several Western countries used varying population-level strategies to id...
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
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Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
IntroductionDespite the range of disease-modifying anti-rheumatic drugs (DMARDs) that have transformed the therapeutic lan...
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
IntroductionAutoinflammatory diseases (AIDs) are genetically determined conditions characterised by recurrent sterile infl...
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
IgG4-related disease (IgG4-RD) was initially discovered as a clearly different entity in patients with sclerosing cholangi...
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
We read with great interest the article by Linge et al 1 on ‘NCF1- 339 polymorphism is associated with altered formation o...
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
A recent phase 3 trial (contRAst 3) with otilimab, a drug targeting granulocyte-macrophage colony-stimulating factor (GM-C...
Potential for biosimilars in rheumatology in Africa
Potential for biosimilars in rheumatology in Africa
Biosimilars are products which are highly similar to a reference biologic product (RBP). In Africa, regulatory frameworks ...
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
WHAT IS ALREADY KNOWN ON THIS TOPICNot all patients with rheumatoid arthritis (RA) achieve effective disease control with ...
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
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Finger ischaemia, enlarged spleen and lung nodules
Finger ischaemia, enlarged spleen and lung nodules
A 48-year-old man presented with a 10 kg weight loss and fever. On examination, there was digital ischaemia (figure 1), oe...
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
WHAT IS ALREADY KNOWN ON THIS TOPICColchicine or non-steroidal anti-inflammatory drug prophylaxis reduces the incidence of...
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
With great interest, we read the results of the tight control in spondyloarthritis (TICOSPA) study1 in which a tight-contr...
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Pain and inflammation are often discordant among patients with rheumatoid arthritis (RA). In a mouse model, systemic injec...
Benralizumab for eosinophilic granulomatosis with polyangiitis
Benralizumab for eosinophilic granulomatosis with polyangiitis
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Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
IntroductionThe extent and severity of skin thickness varies in systemic sclerosis (SSc). In diffuse cutaneous SSc (dcSSc)...
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