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Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
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Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
IntroductionDespite the range of disease-modifying anti-rheumatic drugs (DMARDs) that have transformed the therapeutic lan...
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
IntroductionAutoinflammatory diseases (AIDs) are genetically determined conditions characterised by recurrent sterile infl...
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
IgG4-related disease (IgG4-RD) was initially discovered as a clearly different entity in patients with sclerosing cholangi...
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
We read with great interest the article by Linge et al 1 on ‘NCF1- 339 polymorphism is associated with altered formation o...
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
A recent phase 3 trial (contRAst 3) with otilimab, a drug targeting granulocyte-macrophage colony-stimulating factor (GM-C...
Potential for biosimilars in rheumatology in Africa
Potential for biosimilars in rheumatology in Africa
Biosimilars are products which are highly similar to a reference biologic product (RBP). In Africa, regulatory frameworks ...
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
WHAT IS ALREADY KNOWN ON THIS TOPICNot all patients with rheumatoid arthritis (RA) achieve effective disease control with ...
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
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Finger ischaemia, enlarged spleen and lung nodules
Finger ischaemia, enlarged spleen and lung nodules
A 48-year-old man presented with a 10 kg weight loss and fever. On examination, there was digital ischaemia (figure 1), oe...
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
WHAT IS ALREADY KNOWN ON THIS TOPICColchicine or non-steroidal anti-inflammatory drug prophylaxis reduces the incidence of...
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
With great interest, we read the results of the tight control in spondyloarthritis (TICOSPA) study1 in which a tight-contr...
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Pain and inflammation are often discordant among patients with rheumatoid arthritis (RA). In a mouse model, systemic injec...
Benralizumab for eosinophilic granulomatosis with polyangiitis
Benralizumab for eosinophilic granulomatosis with polyangiitis
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Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
IntroductionThe extent and severity of skin thickness varies in systemic sclerosis (SSc). In diffuse cutaneous SSc (dcSSc)...
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study
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Clinical image: atypical calcification of dorsal spine
Clinical image: atypical calcification of dorsal spine
A previously healthy 46-year-old man presented with constant and awakening dorsal pain and fever for 5 days. There was no ...
Time and dose-dependent effect of systemic glucocorticoids on major adverse cardiovascular event in patients with rheumatoid arthritis: a population-based study
Time and dose-dependent effect of systemic glucocorticoids on major adverse cardiovascular event in patients with rheumatoid arthritis: a population-based study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSIn this population-based real-world database, after controlling for...
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis
WHAT IS ALREADY KNOWN ON THIS TOPICActivation of fibroblasts is crucial for the development of all fibrotic processes, in ...
Nanna Svartz (1890-1986) and the discovery of sulfasalazine
Nanna Svartz (1890-1986) and the discovery of sulfasalazine
On 17 December 1937, the King of Sweden, Gustaf V, signed a document appointing Nanna Svartz (1890–1986) as full professor...
Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases
Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases
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T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases
T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases
Recent technological progress has greatly advanced our understanding of human immunology. In particular, the discovery of ...
Interleukin 4-driven reversal of self-reactive B cell anergy contributes to the pathogenesis of systemic lupus erythematosus
Interleukin 4-driven reversal of self-reactive B cell anergy contributes to the pathogenesis of systemic lupus erythematosus
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Correspondence on 'Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial
Correspondence on 'Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial
We have read with great interest the work of Anna Molto et al studying on comparing the benefits of TICOSPA (a tight contr...
Correspondence on 'Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study
Correspondence on 'Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study
We read with interest the article by Bower et al detailing the impact of the COVID-19 pandemic on mortality and morbidity ...
Correction: Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis
Correction: Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis
Kugler M, Dellinger M, Kartnig F, et al. Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid ...
Correction: Points to consider: EULAR-UEMS standards for the training of European rheumatologists
Correction: Points to consider: EULAR-UEMS standards for the training of European rheumatologists
Alunno A, Avcin T, Haines C, et al. Points to consider: EULAR–UEMS standards for the training of European rheumatologists....
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