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Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of Shouhui Tongbian capsule against diphenoxylate-induced slow transit constipation in rats
Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of Shouhui Tongbian capsule against diphenoxylate-induced slow transit constipation in rats
Slow transit constipation (STC) is highly prevalent and has rising incidence. Shouhui Tongbian capsule (SHTB) is a traditi...
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens
Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens
During the aging process, the number and functional activity of endothelial progenitor cells (EPCs) are impaired, leading ...
PrescDRL: deep reinforcement learning for herbal prescription planning in treatment of chronic diseases
PrescDRL: deep reinforcement learning for herbal prescription planning in treatment of chronic diseases
Treatment planning for chronic diseases is a critical task in medical artificial intelligence, particularly in traditional...
Zhi-Kang-Yin formula attenuates high-fat diet-induced metabolic disorders through modulating gut microbiota-bile acids axis in mice
Zhi-Kang-Yin formula attenuates high-fat diet-induced metabolic disorders through modulating gut microbiota-bile acids axis in mice
Metabolic disorders have become one of the global medical problems. Due to the complexity of its pathogenesis, there is st...
Correction: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation
Correction: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity
Liguzinediol (Lig) has emerged as a promising candidate for mitigating Doxorubicin (DOX)-induced cardiotoxicity, a signifi...
Shaoyao Decoction reduced T lymphocyte activation by regulating of intestinal flora and 5-hydroxytryptamine metabolism in ulcerative colitis
Shaoyao Decoction reduced T lymphocyte activation by regulating of intestinal flora and 5-hydroxytryptamine metabolism in ulcerative colitis
Shaoyao Decoction (SYD) is a widely recognized herbal formula utilized in traditional Chinese medicine for the treatment o...
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy
Resident microglia- and peripheric macrophage-mediated neuroinflammation plays a predominant role in the occurrence and de...
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis
Extended contact with silica particles can lead to Silicosis, a chronic lung condition lacking established treatment proto...
Phytotherapeutic potential against MRSA: mechanisms, synergy, and therapeutic prospects
Phytotherapeutic potential against MRSA: mechanisms, synergy, and therapeutic prospects
Rising resistance to antimicrobials, particularly in the case of methicillin-resistant Staphylococcus aureus (MRSA), repre...
Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival
Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival
Osteoarthritis (OA) is a prevalent global health concern associated with the loss of articular cartilage and subchondral b...
A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis
A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis
Liver cirrhosis is a chronic liver disease with hepatocyte necrosis and lesion. As one of the TCM formulas Wuling Powder (...
Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
Drunkenness and alcoholic liver disease (ALD) are critical public health issues associated with significant morbidity and ...
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling
LanGui tea, a traditional Chinese medicine formulation comprising of Gynostemma pentaphyllum (Thunb.) Makino, Cinnamomum c...
Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis
Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis
Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS...
Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction
Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction
( −)-Epigallocatechin-3-gallate (EGCG), a bioactive polyphenol isolated from green tea, has recently garnered ...
The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges
The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges
Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of ...
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysio...
Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis
Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis
Synovial neovascularization promotes rheumatoid arthritis (RA) progression. Baihu guizhi decoction (BHGZD) has a potential...
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein
Rhein can significantly delay the progression of chronic nephropathy. However, its mechanism of action has not been adequa...
Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia
Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia
Myocardial ischemia (MI) can cause angina, myocardial infarction, and even death. Angiogenesis is beneficial for ensuring ...
Comparative efficacy of Chinese patent medicines in patients with carotid atherosclerotic plaque: a Bayesian network meta− analysis
Comparative efficacy of Chinese patent medicines in patients with carotid atherosclerotic plaque: a Bayesian network meta− analysis
Traditional Chinese patent medicines (TCPMs) have been widely used to treat carotid atherosclerotic plaque (CAP) in China....
Prenylated chromones and flavonoids isolated from the roots of Flemingia macrophylla and their anti-lung cancer activity
Prenylated chromones and flavonoids isolated from the roots of Flemingia macrophylla and their anti-lung cancer activity
The successful launch of icaritin, a therapeutic drug for liver cancer derived from Epimedium brevicornu, has pro...
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species tradition...
Correction: Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
Correction: Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Panax japonicus C.A. Meyer: a comprehensive review on botany, phytochemistry, pharmacology, pharmacokinetics and authentication
Panax japonicus C.A. Meyer: a comprehensive review on botany, phytochemistry, pharmacology, pharmacokinetics and authentication
Panax japonicus C.A. Meyer (Zhujieshen) is widely used in traditional medicine as a tonic hemostatic and anti-inflammatory...
Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice
Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice
In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regul...
Pseudo-allergic reactions induced by Chinese medicine injections: a review
Pseudo-allergic reactions induced by Chinese medicine injections: a review
Traditional Chinese medicine injections (TCMIs) is a new dosage form of Chinese medicine, which plays a unique role in res...
Non-drug interventions of traditional Chinese medicine in preventing type 2 diabetes: a review
Non-drug interventions of traditional Chinese medicine in preventing type 2 diabetes: a review
Traditional Chinese medicine (TCM) is increasingly used to manage type 2 diabetes and its nonpharmacological interventions...
Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system
Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system
Cancer is a malignant disease that has plagued human beings all the time, but the treatment effect of commonly used antica...
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