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Full-length GSDME mediates pyroptosis independent from cleavage
Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing...
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of div...
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RI...
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the ep...
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and ...
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. We reveal th...
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms r...
RIPK1 and necroptosis role in premature ageing
RIPK1 and necroptosis role in premature ageing
Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with...
Reconstituting the dynamic steady states of actin networks in vitro
Reconstituting the dynamic steady states of actin networks in vitro
Despite the constant renewal of their components, cellular actin networks maintain their overall appearance, through a sub...
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Followi...
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for ...
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets precisely in space and time. How R...
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
The human neocortex has undergone strong evolutionary expansion, largely due to an increased progenitor population, the ba...
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Gene expression is regulated by multiple epigenetic mechanisms, which are coordinated in development and disease. However,...
COPIng with senescence
COPIng with senescence
There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer co...
Author Correction: Changing the public perception of human embryology
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, AustriaNi...
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (mye...
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases...
Manganese controls lipoprotein secretion via biomolecular condensation
Manganese controls lipoprotein secretion via biomolecular condensation
By regulating the condensation of the molecular transport machinery coat protein complex II (COPII), manganese ions contri...
Quick tips for interpreting cell death experiments
Quick tips for interpreting cell death experiments
Cell death is an important biological process whose experimental detection and measurement can be difficult, especially wh...
Changing the public perception of human embryology
Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific ad...
Cytosolic transfer of circulating LPS by EVs
Cytosolic transfer of circulating LPS by EVs
The main barriers for intracellular receptors to sense circulating pathogen-associated molecular patterns (PAMPs) is how t...
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Intracellular surveillance for systemic microbial components during homeostasis and infections governs host physiology and...
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