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Seeing tension in cells
Non-muscle myosin II (NMII) generates contractile forces, and Förster resonance energy transfer (FRET)-based tension senso...
To eat or not to eat
During development, haematopoietic stem and progenitor cells (HSPCs) experiencing high cellular stress produce increased l...
Lipid droplet messengers
Group 2 innate lymphoid cells (ILC2s) serve important roles in airway inflammation in asthma. After being activated, ILC2s...
A systemic effect for liver senescence
A systemic effect for liver senescence
A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The wor...
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as ...
FMRP gains mitochondrial fission control
FMRP gains mitochondrial fission control
Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, i...
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Cell state dynamics underlying successful tissue regeneration are undercharacterized. In the intestine, damage prompts epi...
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
Fragile X messenger ribonucleoprotein (FMRP) is a critical regulator of translation, whose dysfunction causes fragile X sy...
Full-length GSDME mediates pyroptosis independent from cleavage
Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing...
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of div...
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RI...
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the ep...
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and ...
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation
Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. We reveal th...
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms r...
RIPK1 and necroptosis role in premature ageing
RIPK1 and necroptosis role in premature ageing
Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with...
Reconstituting the dynamic steady states of actin networks in vitro
Reconstituting the dynamic steady states of actin networks in vitro
Despite the constant renewal of their components, cellular actin networks maintain their overall appearance, through a sub...
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Followi...
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1
Defects in the prelamin A processing enzyme caused by loss-of-function mutations in the ZMPSTE24 gene are responsible for ...
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets
Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets precisely in space and time. How R...
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex
The human neocortex has undergone strong evolutionary expansion, largely due to an increased progenitor population, the ba...
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Gene expression is regulated by multiple epigenetic mechanisms, which are coordinated in development and disease. However,...
COPIng with senescence
COPIng with senescence
There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer co...
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