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Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss
Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesi...
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead...
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19
COVID-19 is an endothelial disease with two key aspects: endotheliopathy causing coagulopathy and angiogenic disorder, par...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
A novel quantitative angiogenesis assay based on visualized vascular organoid
A novel quantitative angiogenesis assay based on visualized vascular organoid
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease pr...
Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers
Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers
Hypertension is unrecognized in more than half of hypertensive patients in r...
Comment on the Article: Risk of pneumonia-related hospitalization after initiating angiotensin-converting enzyme inhibitors compared with angiotensin II receptor blockers: a retrospective cohort study using LIFE Study data
Comment on the Article: Risk of pneumonia-related hospitalization after initiating angiotensin-converting enzyme inhibitors compared with angiotensin II receptor blockers: a retrospective cohort study using LIFE Study data
We have carefully reviewed the article titled “Risk of pneumonia-related hos...
Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water
Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water
Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, et al. Prevalence of Cardiovascular Disease and Its Risk Factors...
Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review
Updated meta-analysis for antihypertensive treatment guided by home blood pressure compared to treatment based on office blood pressure: systematic review
Home blood pressure (BP) measurement is widely used, and home BP plays a central role in hypertension management in clinic...
Prognostic value of beat-to-beat blood pressure variability parameters in patients after mechanical thrombectomy
Prognostic value of beat-to-beat blood pressure variability parameters in patients after mechanical thrombectomy
The relationship of beat-to-beat blood pressure variability (BPV) with prognosis after mechanical thrombectomy (MT) is unc...
Highlights of the 2024 Chinese hypertension guidelines
Highlights of the 2024 Chinese hypertension guidelines
The 2024 Chinese hypertension guidelines has been recently issued by Chinese Hypertension League (CHL), joint with partner...
Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak
Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak
Previous studies have shown an increase in blood pressure during the coronavirus disease 2019 (COVID-19) pandemic even amo...
Intraindividual correlations between nocturnal urination frequency and sleep blood pressure: the Nagahama Study
Intraindividual correlations between nocturnal urination frequency and sleep blood pressure: the Nagahama Study
Nocturnal urination frequency is associated with sleep blood pressure (BP). However, it was uncertain to what extent the s...
Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
To review what intestinal permeability is and how it is measured, and to summarise the current evidence linking altered in...
Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure
Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure
Preserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the p...
White Coat Hypertension & Cardiovascular Outcomes
White Coat Hypertension & Cardiovascular Outcomes
This review aims to inform the reader of the complexity of blood pressure responses when comparing blood pressure measured...
Diet to Stop Hypertension: Should Fats be Included?
Diet to Stop Hypertension: Should Fats be Included?
International guidelines emphasize advice to incorporate dietary measures for the prevention and in the management of hype...
Intradialytic Hypertension in Maintenance Hemodialysis
Intradialytic Hypertension in Maintenance Hemodialysis
To summarize the current evidence regarding epidemiology, clinical pathophysiology, and latest therapeutic approaches for ...
Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure
Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure
The role of leptin in regulating cardiac function is still controversial with conflicting results in clinical and preclini...
Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies
Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies
For a healthy pregnancy to occur, a controlled interplay between the maternal circulating renin–angiotensin–al...
Insights into Uromodulin and Blood Pressure
Insights into Uromodulin and Blood Pressure
We review the role of uromodulin, a protein exclusively expressed in the kidney, in blood pressure regulation and hyperten...
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
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