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scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages
scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages
The increased incidence of inflammatory diseases, infectious diseases, autoimmune disorders, and tumors in elderly individ...
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents
As older age and having certain comorbidities can influence humoral responses to vaccination, we studied antibody response...
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats
Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from ou...
Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART
Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART
Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, res...
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
The characteristics of ulcerative colitis (UC) in the elderly are quite different from the young population. Mitochondrial...
Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches
Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches
Sarcopenia is a complex age-associated syndrome of progressive loss of muscle mass and strength. Although this condition i...
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna
Mouse brains can contain specific polyglucosan aggregates known as Periodic Acid-Schiff (PAS)-granules. Generated in astro...
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice
Aging is a complex biological process characterized by obesity and immunosenescence throughout the organism. Immunosenesce...
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities ...
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized ...
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly...
Impact of NAD+ metabolism on ovarian aging
Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-r...
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remai...
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T...
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adver...
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to...
Toll-like receptor 4 (TLR4): new insight immune and aging
Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous l...
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to th...
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. W...
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease...
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months ...
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatr...
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Ad...
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized...
Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related vari...
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics...
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic co...
Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degen...
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