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Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities ...
Immunity & Ageing
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Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized ...
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Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly...
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Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-r...
Immunity & Ageing
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Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remai...
Immunity & Ageing
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Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T...
Immunity & Ageing
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Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adver...
Immunity & Ageing
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Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Immunity & Ageing
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Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to...
Immunity & Ageing
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Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous l...
Immunity & Ageing
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Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to th...
Immunity & Ageing
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Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. W...
Immunity & Ageing
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Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease...
Immunity & Ageing
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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months ...
Immunity & Ageing
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Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatr...
Immunity & Ageing
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A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Ad...
Immunity & Ageing
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TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized...
Immunity & Ageing
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Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Immunity & Ageing
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Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related vari...
Immunity & Ageing
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Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics...
Immunity & Ageing
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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic co...
Immunity & Ageing
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Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degen...
Immunity & Ageing
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Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “in...
Immunity & Ageing
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Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hid...
Immunity & Ageing
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Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inf...
Immunity & Ageing
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Transcriptional characteristics and functional validation of three monocyte subsets during aging
Age-associated changes in immunity are inextricably linked to chronic inflammation and age-related diseases, the impact of...
Immunity & Ageing
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Towards a better preclinical cancer model – human immune aging in humanized mice
Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models h...
Immunity & Ageing
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Related factors of renal injury in primary Sjögren's syndrome
Primary Sjögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the e...
Immunity & Ageing
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Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circ...
Immunity & Ageing
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Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressi...
Immunity & Ageing
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