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A comprehensive single-cell atlas of three centenarian cohorts unveils unique natural killer cell signatures and enhanced mutual interactions among peripheral immune cells
Volume 120, October 2025, 105922Author links open overlay panel, , , , , , , , , , , , , , , SummaryBackgroundCentenarians...
Fitness costs of mobilised colistin resistance gene 3 (mcr-3): systematic review, epidemiological study, and functional analysis
Volume 120, October 2025, 105923Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBackgroundThe...
Impact of systemic SARS-CoV-2 vaccination on mucosal IgA responses to subsequent breakthrough infection
Volume 120, October 2025, 105912Author links open overlay panel, , , , , , , , , , SummaryBackgroundMucosal IgA responses ...
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling
Volume 120, October 2025, 105920Author links open overlay panel, , , , , , , , , , , , SummaryBackgroundTreatments availab...
Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease
Volume 120, October 2025, 105924Author links open overlay panel, , , , , , , , , , , SummaryBackgroundDespite recent appro...
PNPLA3 polymorphism worsens chemotherapy associated liver injury and affects overall survival in colorectal cancer patients with liver metastasis undergoing hepatic resection
Volume 120, October 2025, 105928Author links open overlay panel, , , , , , , , , , , , , , , , , , , SummaryBackgroundNeoa...
Directed-complement killing of Pseudomonas aeruginosa protects against lethal pneumonia
Volume 120, October 2025, 105926Author links open overlay panel, , , , , , , , , , , , , , , SummaryBackgroundMultidrug-re...
Microplastic abundance in placental chorionic villi detected by pyrolysis-gas chromatography/mass spectrometry in cases of spontaneous miscarriage during early pregnancy
Volume 120, October 2025, 105918Author links open overlay panel, , , , , , SummaryBackgroundThere is widespread concern re...
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate the IFN-α-induced crosstalk between JAK/STAT and MAPKs pathways in human beta cells
Volume 120, October 2025, 105932Author links open overlay panel, , , , , , , , , , , , SummaryBackgroundType 1 diabetes (T...
Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
Volume 120, October 2025, 105946Author links open overlay panel, , , , , , , , SummaryBackgroundType 1 diabetes (T1D) is c...
Identification of potential therapeutic targets for problematic alcohol use using multi-omics data
Volume 120, October 2025, 105939Author links open overlay panel, , , , , , , , SummaryBackgroundProblematic alcohol use (P...
Efficacy of precisely tailored phage cocktails targeting carbapenem-resistant Acinetobacter baumannii reveals evolutionary trade-offs: a proof-of-concept study
Volume 120, October 2025, 105942Author links open overlay panel, , , , , , , , , , , , , , SummaryBackgroundThe rapid emer...
Safety and immunogenicity of two Tau-targeting active immunotherapies, ACI-35.030 and JACI-35.054, in participants with early Alzheimer's disease: a phase 1b/2a, multicentre, double-blind, randomised, placebo-controlled study
Volume 120, October 2025, 105940Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBackgroundAct...
Plasma neurology-related proteins associated with cognition are modulated by lifestyle in adults
BackgroundCognitive decline (CD) is an age-related process exacerbated by metabolic syndrome (MetS), which may be mitigate...
Comparative analysis of cerebrospinal fluid neurofilament medium, light and heavy chain in neurodegenerative diseases using an in-house assay for the detection of neurofilament medium chain
BackgroundNeurofilaments are key axonal proteins, with neurofilament light (NfL) and heavy (NfH) chain recognised as promi...
Prospective associations of obesity heterogeneity, serum proteins, and carotid atherosclerosis risk
Volume 120, October 2025, 105935Author links open overlay panel, , , , , , , , , , , SummaryBackgroundObese individuals ex...
Smouldering disease in paediatric-onset multiple sclerosis
Volume 120, October 2025, 105921Author links open overlay panel, , , , , , , , , , , SummarySmouldering disease in multipl...
Iron—sepsis associations in population health revealed by epidemiology
Volume 120, October 2025, 105927Author links open overlay panel, , , SummarySepsis is a leading cause of death and disabil...
α-Synuclein seed amplification assay positivity beyond synucleinopathies
Volume 120, October 2025, 105925Author links open overlay panel, , , , SummaryNeurodegenerative diseases are increasingly ...
Correction: Transcription factor 7 promotes the progression of perihilar cholangiocarcinoma by inducing the transcription of c-Myc and FOS-like antigen 1
Volume 120, October 2025, 105913Author links open overlay panelZengli Liu a d, Rongqi Sun a d, Xiaoming Zhang b, Bo Qiu a,...
Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D3-loaded lipid nanoparticles (Vit D3-LNP), integrated into an azulene cream, were developed to enhance the topica...
Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant
Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant
Knee osteoarthritis (OA), a degenerative joint disease, is increasingly prevalent worldwide and often results from a menis...
Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device
Isolation of bacterial extracellular vesicles from raw samples using a portable microstructured electrochemical device
Bacterial extracellular vesicles (EVs) are nanosized vesicles released by both Gram-negative and Gram-positive bacteria, p...
Microneedle-mediated delivery of hydroxypropyl--cyclodextrin-encapsulated (Danggui) essential oil for acne treatment: efficacy and mechanisms
Microneedle-mediated delivery of hydroxypropyl--cyclodextrin-encapsulated (Danggui) essential oil for acne treatment: efficacy and mechanisms
Acne is a multifactorial dermatological condition driven by Propionibacterium acnes (P. acnes) infection, inflammation, an...
Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption
Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption
Ulcerative colitis (UC), an inflammatory bowel disease, poses a severe threat to human health. Paeonol has demonstrated po...
Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template
Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template
Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting ...
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery
Hypoxia is a key feature of solid tumors, contributing to therapeutic resistance and poor prognosis. Targeting hypoxic env...
Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus
Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus
Messenger RNA (mRNA) therapeutics have shown considerable promise across a wide range of medical applications with lipid n...
Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson’s disease treatment by intranasal administration
Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson’s disease treatment by intranasal administration
The main aim of this work was to synthesize new chitosan amphiphilic derivatives able to self-assembly encapsulating subst...
Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure
Delivery of monoclonal antibodies to the brain: the impact of nanocarrier structure
Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. Ho...
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