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Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
Adenosine is a ubiquitous endogenous molecule capable of influencing several pathophysiological aspects. The adenosine sys...
A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
Non-communicable chronic diseases are characterized by low-grade inflammation and oxidative stress. Extensive research has...
Correction: Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Correction: Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes
Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes
The organic cation transporter 3 (OCT3) is a ubiquitous transporter that carries both endogenous and exogenous substrates,...
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
Clinical research has identified stomach dysmotility as a common feature of obesity. However, the specific mechanisms driv...
Exploring paraptosis as a therapeutic approach in cancer treatment
Exploring paraptosis as a therapeutic approach in cancer treatment
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis,&nb...
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly a...
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dent...
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with unde...
Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually ...
BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability
BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability
Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance gene...
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as ...
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Dectin-1 is a transmembrane receptor that plays a pivotal role in recognising fungi and Mycobacterium tuberculosis (Mtb). ...
A matter of new life and cell death: programmed cell death in the mammalian ovary
A matter of new life and cell death: programmed cell death in the mammalian ovary
The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproduc...
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR&...
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance an...
Significance of hepatitis B virus capsid dephosphorylation via polymerase
Significance of hepatitis B virus capsid dephosphorylation via polymerase
It is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral D...
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently m...
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis...
Butterflies in the gut: the interplay between intestinal microbiota and stress
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk ...
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in dange...
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remain...
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological m...
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles exten...
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (S...
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (m...
Extracellular release in the quality control of the mammalian mitochondria
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mit...
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The ...
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class...
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