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Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Alzheimer disease (AD) is the most common form of dementia affecting more than 6 million people in the United States. Curr...
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement f...
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Progressive supranuclear palsy (PSP) is mainly a sporadic disease. It has a multifactorial etiology and an interaction bet...
Outcome-associated factors in a molecularly defined cohort of central neurocytoma
Outcome-associated factors in a molecularly defined cohort of central neurocytoma
Central neurocytomas (CN) are intraventricular brain tumors predominantly occurring in young adults. Although prognosis is...
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
The mutation E200K in the prion protein gene (PRNP) is the most common variant in genetic Creutzfeldt–Jakob disease ...
Role of CSF flow and meningeal barriers in the development of inflammatory lesions at the CNS–PNS transition zone of cranial nerves in autoimmune demyelinating diseases
Role of CSF flow and meningeal barriers in the development of inflammatory lesions at the CNS–PNS transition zone of cranial nerves in autoimmune demyelinating diseases
Patients with autoimmune inflammatory demyelinating diseases have been shown to present with trigeminal and cochlear nerve...
The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system
The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system
Olfactory impairment is a recognized early indicator of neurodegenerative diseases (NDs), such as Alzheimer’s diseas...
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice
Our recent work on the prion protein and Na+, K+-ATPases (NKAs) led us to revisit data from over 50 years ago, wh...
CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma
CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma
Methylation profiling for tumor classification has entered mainstream neuropathology ...
Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants
Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants
The identification of biomarkers predicting the burden of brain alpha-synuclein (α-syn) pathology in vivo represents ...
Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature
Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Subclinical detection of misfolded alpha-synuclein in the blood of M83 mice
Subclinical detection of misfolded alpha-synuclein in the blood of M83 mice
Barbour R, Kling K, Anderson JP, Banducci K, Cole T, Diep L et al (2008) Red blood cells are the major source of alpha-syn...
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder marked by amyloid-β (Aβ) deposition in blood ves...
Primary papillary epithelial tumor of the sella harboring an Y646F mutation
Primary papillary epithelial tumor of the sella harboring an Y646F mutation
Sellar and suprasellar tumors encompass a heterogeneous array of neoplasms, including...
Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease
Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease
Translocator protein 18 kDA (TSPO) imaging using positron emission tomography (PET) is widely used to assess neuroinflamma...
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits
ATP10B, a transmembrane lipid flippase located in late endosomes and lysosomes, facilitates the export of glucosylceramide...
Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum
Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum
Extracellular amyloid plaques, the pathognomonic hallmark of Alzheimer’s disease (AD), are also observed in cognitiv...
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Aguilar-Calvo P, Callender JA, Sigurdson CJ (2021) Short and sweet: How glycans impact prion conversion, cofactor interact...
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Aggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and ...
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer’s disease (AD), with higher bloo...
BAG3’s dual roles in Parkinson’s disease and cardiomyopathy: benefit or liability?
BAG3’s dual roles in Parkinson’s disease and cardiomyopathy: benefit or liability?
Antoku K, Maser RS, Scully WJ, Delach SM, Johnson DE (2001) Isolation of Bcl-2 binding proteins that exhibit homology with...
SMOC1 colocalizes with Alzheimer’s disease neuropathology and delays Aβ aggregation
SMOC1 colocalizes with Alzheimer’s disease neuropathology and delays Aβ aggregation
SMOC1 has emerged as one of the most significant and consistent new biomarkers of early Alzheimer’s disease (AD). Re...
Lipid storage myopathy associated with sertraline treatment is an acquired mitochondrial disorder with respiratory chain deficiency
Lipid storage myopathy associated with sertraline treatment is an acquired mitochondrial disorder with respiratory chain deficiency
Lipid storage myopathies are considered inborn errors of metabolism affecting the fatty acid metabolism and leading to acc...
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to c...
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
Cancer-intrinsic immune evasion mechanisms and pleiotropy are a barrier to cancer immunotherapy. This is apparent in certa...
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Sudden unexplained death in childhood (SUDC) is death of a child ≥ 12 months old that is unexpl...
MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion
MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion
Cuoco JA, Williams S, Klein BJ, Borowicz VM, Ho H, Stump MS et al (2024) Astroblastoma with a novel YAP1::BEND2 fusion: a ...
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson&...
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas
Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP et al (2017) Therapeutic radiation for childhood cancer dri...
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-pre...
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