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Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer ...
Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells
Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells
Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to vario...
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhyt...
Implementing the EU HTA regulation: Insights from semi-structured interviews on patient expectations, Belgian and European institutional perspectives, and industry outlooks
Implementing the EU HTA regulation: Insights from semi-structured interviews on patient expectations, Belgian and European institutional perspectives, and industry outlooks
Introduction: The goal of the Health Technology Assessment (HTA) Regulation 2021/2282 is to establish a more harmonized HT...
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Introduction: One of the primary obstacles faced by individuals with advanced colorectal cancer (CRC) is the potential dev...
How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?
How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?
Common bile duct stones, as a type of cholelithiasis, are a benign biliary obstruction that easily acute abdominalgia, and...
Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis
Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis
We performed a Bayesian network meta-analysis to indirectly compare the relative efficacy and safety of the latest JAK inh...
Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair
Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair
Cholangiocarcinoma (CCA) is a highly heterogeneous tumor that occurs in the bile duct epithelium; adenosquamous carcinoma ...
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Access to a tailored mobile application enhances medication adherence among young users of antidepressants
Introduction:Patients’ adherence to antidepressants is generally reported to be poor. This study examined whether users of...
Editorial: Structural and functional venomics as a powerful approach for drug discovery and development
Editorial: Structural and functional venomics as a powerful approach for drug discovery and development
The diversity of terrestrial and marine venomous creatures is extremely high with more than 200,000 species spread through...
Machine learning-based identification of a consensus immune-derived gene signature to improve head and neck squamous cell carcinoma therapy and outcome
Machine learning-based identification of a consensus immune-derived gene signature to improve head and neck squamous cell carcinoma therapy and outcome
BackgroundHead and neck squamous cell carcinoma (HNSCC), an extremely aggressive tumor, is often associated with poor outc...
Editorial: Drug discovery and nano delivery of natural products
Editorial: Drug discovery and nano delivery of natural products
Natural products refer to single-component or multi-component active agents that come from animals, plants, and other orga...
Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA
Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA
The virulence of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), depends on the expression of tox...
Metabolic vulnerability of cancer stem cells and their niche
Metabolic vulnerability of cancer stem cells and their niche
Cancer stem cells (CSC) are the leading cause of the failure of anti-tumor treatments. These aggressive cancer cells are p...
Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone
Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone
Idiosyncratic drug-induced liver injury (iDILI) is a major concern in drug development because its occurrence is unpredict...
Bactericidal and biofilm eradication efficacy of a fluorinated benzimidazole derivative, TFBZ, against methicillin-resistant Staphylococcus aureus
Bactericidal and biofilm eradication efficacy of a fluorinated benzimidazole derivative, TFBZ, against methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is a major inducement of nosocomial infections and its biofilm formatio...
Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy
Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy
As the quality of life improves, the incidence of diabetes mellitus and its microvascular complications (DMC) continues to...
The potential of astragalus polysaccharide for treating diabetes and its action mechanism
The potential of astragalus polysaccharide for treating diabetes and its action mechanism
Type 2 diabetes presents a significant global health burden and is frequently linked to serious clinical complications, in...
Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis
Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis
BackgroundAlthough Shen Gui capsules (SGCP) are widely used as an adjuvant treatment for chronic heart failure (CHF), thei...
Counter-regulatory RAS peptides: new therapy targets for inflammation and fibrotic diseases?
Counter-regulatory RAS peptides: new therapy targets for inflammation and fibrotic diseases?
The renin-angiotensin system (RAS) is an important cascade of enzymes and peptides that regulates blood pressure, volume, ...
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application...
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however ...
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however t...
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation the...
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
With the implementation of the ConPhyMP reporting tool as an element of peer review in Frontiers in Pharmacology, Section ...
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This stu...
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increa...
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKI...
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Objective: To systematically evaluate the efficacy and safety of the Chinese medicine detoxification and dredging collater...
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often ...
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