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Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Introduction: Major depressive disorder (MDD), characterized by severe neuropsychiatric symptoms and significant cognitive...
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
IntroductionHelicobacter pylori causes chronic gastric diseases in nearly 50% of people around the world. It is suggested ...
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
BackgroundFluoroquinolones are broad-spectrum antibiotics with significant antimicrobial activity. Despite their therapeut...
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
IntroductionThe resolution of the skin’s inflammatory response is only possible if its barrier function is restored. TRPV1...
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Squamous cell carcinoma of the head and neck (HNSCC) is a difficult-to-treat cancer and treatment is challenging due to re...
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonl...
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness ...
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Background: Increasing student numbers and logistical challenges in pharmacy education limit patient counselling and clini...
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
IntroductionEthambutol, a key anti-tuberculosis medication, is associated with optic neuropathy, which can lead to signifi...
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
IntroductionPolypharmacy is a growing concern in healthcare systems. While available data on potential drug-drug interacti...
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
ObjectivesSingle-strand DNA-binding protein 1 (SSB1) plays a crucial role in the cellular response to DNA damage. This stu...
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
IntroductionDue to the high mortality rate and increasing severity of antibiotic resistance, there is a growing interest i...
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics
BackgroundHyponatremia is a common electrolyte disturbance and known adverse drug reaction of diuretics. Women tend to be ...
Editorial: Advanced neural stem cell therapies for spinal cord injury
This edition of Frontiers in Pharmacology is dedicated to sharing the progress in spinal cord injury research. A total of ...
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets
BackgroundAtrial fibrillation (AF) and breast cancer pose significant risks to human health. The reasons behind the concur...
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records
Background and ObjectiveChronic atrophic gastritis (CAG) is a complex chronic disease caused by multiple factors that freq...
The forensic aspects of suicide and neurotrophin factors: a research study
The forensic aspects of suicide and neurotrophin factors: a research study
Introduction: Suicide represents a significant public health problem whose neurobiology is not yet fully understood. In ma...
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes
IntroductionPregnancy results in significant changes in drug pharmacokinetics (PK). While previous studies have elucidated...
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