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New frontiers in sulfur and selenium chemical biology
New frontiers in sulfur and selenium chemical biology
Kate S. Carroll is a Professor in the Department of Chemistry at the Herbert Werthheim UF Scripps Institute for Biomedical...
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
In the rhizosphere, plants and microbes communicate chemically, especially under environmental stress. Over millions of ye...
Versatile roles of cysteine persulfides in tumor biology
Versatile roles of cysteine persulfides in tumor biology
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in ...
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
The dynamic equilibrium between the generation of reactive oxygen species (ROS) and the antioxidative defense mechanisms w...
A new era of cysteine proteomics – Technological advances in thiol biology
A new era of cysteine proteomics – Technological advances in thiol biology
Protein cysteines garner interest for their distinct chemical properties, rendering them amenable to a diverse range of mo...
Biochemistry of the hypoxia-inducible factor hydroxylases
Biochemistry of the hypoxia-inducible factor hydroxylases
KeywordsHypoxia-inducible factor (HIF)HIF prolyl-hydroxylases (PHDs/EGLNs)JmjC demethylasesFactor inhibiting HIF (FIH)Aspa...
Lumos maxima – How robust fluorophores resist photobleaching?
Lumos maxima – How robust fluorophores resist photobleaching?
Advanced fluorescence imaging technology, jointly enabled by microscopes and cutting-edge fluorescent labels, promises to ...
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Functional imaging of enzyme activity in living systems provides valuable insights into biological processes and disease s...
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Protein glycosylation, as one of the most widespread and complex post-translational modifications (PTMs), plays an importa...
Site-specific protein labeling strategies for super-resolution microscopy
Site-specific protein labeling strategies for super-resolution microscopy
KeywordsSite-specific labelingSuper-resolution microscopyPeptide-tagPeptide-PAINTUnnatural amino acidNon-canonical amino a...
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Many modern pursuits of molecular biology and biochemistry are built on precise and selective protein labeling techniques....
Fluorogenic polymethine dyes by intramolecular cyclization
Fluorogenic polymethine dyes by intramolecular cyclization
KeywordsFluorogenicityCarbocyaninesPolymethine dyesTurn-on probesIntramolecular cyclizationsSelf-labeling protein tagsSmal...
Chemical toolbox to interrogate Heparanase-1 activity
Chemical toolbox to interrogate Heparanase-1 activity
Heparanase-1 (HPSE-1), an endo-β-d-glucuronidase, is the only known enzyme that cleaves heparan sulfate (HS) [1,2]. The HP...
Chemical biology tools to probe bacterial glycans
Chemical biology tools to probe bacterial glycans
Bacterial cells are covered by a complex carbohydrate coat of armor that allows bacteria to thrive in a range of environme...
Advances in understanding and exploiting Siglec–glycan interactions
Advances in understanding and exploiting Siglec–glycan interactions
Siglecssialic-acid-binding immunoglobulin-type lectinsSAMPself-associated molecular patternITIMimmunoreceptor-tyrosine-bas...
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Heparan sulfate (HS) is an important class of polysaccharides that plays roles in a wide range of biological events, inclu...
A personal perspective of the voltage-gated potassium channel studies
The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, op...
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau f...
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS a...
Shifting our perspective on orphan G protein-coupled receptors
G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves...
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-k...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-a...
SCAF1 drives the compositional diversity of mammalian respirasomes
SCAF1 drives the compositional diversity of mammalian respirasomes
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their ro...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Author notesThese authors contributed equally: Madeleine Stauffer, Leslie Salas-Estrada.Authors and AffiliationsDepartment...
Correction: Lentivirus-Mediated Overexpression of SIVA-1 Reverses Cisplatin Resistance in Gastric Cancer in vitro
Correction: Lentivirus-Mediated Overexpression of SIVA-1 Reverses Cisplatin Resistance in Gastric Cancer in vitro
Correction to: Cell Biochemistry and Biophysics (2020) 78:455–463In the original publ...
Correction: THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer
Correction: THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer
In the published article Pu Y, Wei J, Wu Y, Zhao K, Wu Y, Wu S, Yang X, Xing C. THUMPD3-AS1 facilitates cell growth and ag...
β-carotene inhibits MAPKs signaling pathways on rat colonic epithelial cells to attenuate TNF-α-induced intestinal inflammation and injury
β-carotene inhibits MAPKs signaling pathways on rat colonic epithelial cells to attenuate TNF-α-induced intestinal inflammation and injury
This experiment successfully isolated the rat colonic epithelial cells and established a TNF-α-induced intestinal inf...
HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy
HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy
High mobility group protein AT-hook 1 (HMGA1), an architectural transcription factor, has previously been reportedto play ...
Effect and Mechanism of Mycobacterium avium MAV-5183 on Apoptosis of Mouse Ana-1 Macrophages
Effect and Mechanism of Mycobacterium avium MAV-5183 on Apoptosis of Mouse Ana-1 Macrophages
To investigate the effects and mechanisms of Mycobacterium avium MAV-5183 protein on apoptosis in mouse Ana-1 macrophages....
DEAD Box RNA Helicases: Biochemical Properties, Role in RNA Processing and Ribosome Biogenesis
DEAD Box RNA Helicases: Biochemical Properties, Role in RNA Processing and Ribosome Biogenesis
DEAD box RNA helicases are a versatile group of ATP dependent enzymes that play an essential role in cellular processes li...
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