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(‐)‐Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high‐fat diet
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Optimization of application schedule of camphecene, a novel anti‐influenza compound, based on its pharmacokinetic characteristics
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The synthesis and antineoplastic activities of thiaziridine, sulfidomethylphosphonium, dithiaphosphitane‐sulphide against the Ehrlich ascites carcinoma
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Clinical pharmacology: Current innovations and future challenges
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High glucose upregulates PAR‐1 in SH‐SY5Y cells via deficiency of miR‐20a and miR‐190a
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Transforming growth factor‐β1 inhibits interleukin‐1β‐induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
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Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and anti‐ oxidative activities
Abstract Being the most essential organ in the body, the liver performs critical functions. Hepatic disorders, such as alc...
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Safety concerns on the abuse potential of esketamine: multidimensional analysis of a new anti‐depressive drug on the market
Abstract Background Prominent features of esketamine (e.g., similar mechanism of action as ketamine and target population)...
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Characterization of benzodiazepine misuse and comorbidities in patients with alcohol use disorder
Abstract Background Due to the frequent presence of anxious symptoms and sleep disorders, benzodiazepines (BZD) are often ...
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Characteristics, treatment patterns and residual cardiovascular risk of patients with a first acute myocardial infarction: A nationwide population‐based cohort study in Norway
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High glucose up‐regulates PAR‐1 in SH‐SY5Y cells via deficiency of miR‐20a and miR‐190a
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Activation of spinal ephrin‐B3/EphBs signaling induces hyperalgesia through a PLP‐mediated mechanism
Abstract Ephrin B/EphB signaling pathway is involved in the regulation of pain caused by spinal cord injury. However, the ...
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Everolimus: A potential therapeutic agent targeting PI3K/Akt pathway in brain insulin system dysfunction and associated neurobehavioral deficits
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Fundamental & Clinical Pharmacology
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Chronic use of renin‐angiotensin‐aldosterone system blockers and mortality in COVID‐19: A multicenter prospective cohort and literature review
Abstract Aims The role of renin-angiotensin-aldosterone system (RAAS) blockers on the course of coronavirus disease 2019 (...
Fundamental & Clinical Pharmacology
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Short‐chain fatty acids increase intracellular calcium levels and enhance gut hormone release from STC‐1 cells via transient receptor potential Ankyrin1
Abstract Short-chain fatty acids (SCFAs), metabolites of colonic bacterial fermentation of complex carbohydrates, are clos...
Fundamental & Clinical Pharmacology
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Improvement of cognitive function, glucose and lipid homeostasis and serum osteocalcin levels by liraglutide in diabetic rats
Abstract Background Glucose and lipid abnormalities, oxidative stress (OXS) and reduced brain-derived neurotrophic factor ...
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Trends in the use of antihistamines with reference to drivers between 2015 and 2019: A population‐based registry analysis
Abstract Background First-generation antihistamines are considered driving-impairing medicines (DIM), while second- and th...
Fundamental & Clinical Pharmacology
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What changes in prescription patterns of antiemetic medications in pregnant women in France?
Abstract Background In France, few data are available on the prescription patterns of antiemetic medications in pregnant w...
Fundamental & Clinical Pharmacology
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Effect of dapagliflozin and/or L‐arginine on solid tumor model in mice: The interaction between nitric oxide, transforming growth factor‐beta 1, autophagy, and apoptosis
Abstract Background Nitric oxide was reported to play an essential role in various physiological and pathological processe...
Fundamental & Clinical Pharmacology
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Kappa‐opioid receptor‐mediated thermal analgesia evoked by the intrathecal administration of the chemokine CCL1 in mice
Abstract Background The chemokine CC motif ligand 1 (CCL1) participates in immune cell recruitment and, as other chemokine...
Fundamental & Clinical Pharmacology
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Combination of human papillomaviruses L1 and L2 multiepitope constructs protects mice against tumor cells
Abstract Different types of cancer including cervical (>90%), anal (~88%), vaginal (~40%), and penile (~40%) cancers ar...
Fundamental & Clinical Pharmacology
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The numerical probability of carcinogenicity to humans of some pharmaceutical drugs: Alkylating agents, topoisomerase inhibitors or poisons, and DNA intercalators
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Fundamental & Clinical Pharmacology
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Towards therapeutic drug monitoring of mycophenolic acid in mucous membrane pemphigoid: A retrospective single‐centre study
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Fundamental & Clinical Pharmacology
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Induction of microtubule hyper stabilization and robust G2/M arrest by N‐4‐CN in human breast carcinoma MDA‐MB‐231 cells
Abstract Aim Elucidation of the antiproliferative efficacy and mechanism of action of a design-optimized noscapine analog,...
Fundamental & Clinical Pharmacology
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Variability of rituximab and tocilizumab trough concentrations in patients with rheumatoid arthritis
Abstract Patients with rheumatoid arthritis (RA) are eligible for treatment with therapeutic monoclonal antibodies (mAbs) ...
Fundamental & Clinical Pharmacology
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Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?
Abstract Diarrhea is an adverse drug reaction (ADR) widely reported with olmesartan, an angiotensin II receptor blocker (A...
Fundamental & Clinical Pharmacology
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Recognition of potential therapeutic role of 2‐hydroxy‐3‐methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis
Abstract Background Gallbladder carcinoma (GBC), with early metastasis and high recurrence rates, is a enormous threat to ...
Fundamental & Clinical Pharmacology
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Antidepressants abuse in subjects with opioid use disorders: a 10‐year study in the French OPPIDUM program
Abstract Background Accumulating evidence shows that some antidepressants are abused for their psychostimulant effects, bu...
Fundamental & Clinical Pharmacology
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Relative Bioavailability and Pharmacokinetic Comparison of a Fixed‐Dose Combination Tablet of Mosapride, Pancreatin and Simethicone Relative to Single‐component Mosapride Tablets in Healthy Mexican Subjects
Abstract Abbott Laboratories de México S.A. de C.V. developed a new fixed dose combination of mosapride 5 mg, pancrea...
Fundamental & Clinical Pharmacology
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Vortioxetine as an analgesic in preclinical inflammatory pain models: mechanism of action
Abstract Background Vortioxetine is a novel atypical antidepressant with multimodal activity that has recently demonstrate...
Fundamental & Clinical Pharmacology
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