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Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Huntington’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the bra...
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people ...
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorb...
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enha...
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the mortality rate of myocardial in...
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Piperine is an amide alkaloid responsible for producing the pungent smell that comes from black pepper. Piperine has been ...
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
This study comprehensively explores the complexities of rheumatoid arthritis during pregnancy and its impact on offspring....
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Garcinia pedunculata, a tropical plant found abundantly in the north-east region of India, has been used by many tradition...
Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
Owing to controversy information surrounds effect of glucocorticoids on the evolution of COVID-19, we evaluate the effects...
Acellular spinal cord scaffold containing quercetin-encapsulated nanoparticles plays an anti-inflammatory role in functional recovery from spinal cord injury in rats
Acellular spinal cord scaffold containing quercetin-encapsulated nanoparticles plays an anti-inflammatory role in functional recovery from spinal cord injury in rats
Inflammatory responses play a crucial role in the pathophysiology of spinal cord injury (SCI) and developing new approache...
Epi-revolution in rheumatology: the potential of histone deacetylase inhibitors for targeted rheumatoid arthritis intervention
Epi-revolution in rheumatology: the potential of histone deacetylase inhibitors for targeted rheumatoid arthritis intervention
Autoimmune diseases hold significant importance in the realm of medical research, prompting a thorough exploration of pote...
Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10
Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10
Launaea fragilis (Asso) Pau is a Cholistan desert medicinal plant. Launaea species are used as traditional remedies agains...
Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network
Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network
Micromeria biflora (M.B) Benth has proven anti-inflammatory efficacy, thereby, the goal of the current investigation was t...
Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review
Pulmonary fibrosis (PF) is the end stage of lung injury and chronic lung diseases that results in diminished lung function...
Ethanol extract of Ziziphus nummularia ameliorates formaldehyde-induced arthritis in rats by regulating oxidative stress biomarkers and haematological profile
Ethanol extract of Ziziphus nummularia ameliorates formaldehyde-induced arthritis in rats by regulating oxidative stress biomarkers and haematological profile
Rheumatoid arthritis is an autoimmune inflammatory disorder that mainly affects bone and cartilage architecture. The conti...
Arbutin attenuates CFA-induced arthritis by modulating expression levels of 5-LOX, NF‑κB, IL-17, PGE-2 and TNF-α
Arbutin attenuates CFA-induced arthritis by modulating expression levels of 5-LOX, NF‑κB, IL-17, PGE-2 and TNF-α
Arbutin, a naturally soluble glycosylated phenol has antioxidant, antimicrobial, antitumor and anti-inflammatory propertie...
Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Inflammatory bowel diseases (IBDs) are prevalent and debilitating diseases with limited clinical treatment strategies. Mes...
Novel combination of Olesoxime/Resveratrol-encapsulated exosomes to improve cognitive function by targeting amyloid β-induced Alzheimer’s disease: investigation on in vitro and in vivo model
Novel combination of Olesoxime/Resveratrol-encapsulated exosomes to improve cognitive function by targeting amyloid β-induced Alzheimer’s disease: investigation on in vitro and in vivo model
Alzheimer's disease (AD) is a fatal neurological illness that worsens with time. Preventing the aggregate formation of...
Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19
Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19
Small intestine damage caused by diclofenac is called diclofenac enteropathy. Berberine (BBR), a class of isoquinoline alk...
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
Cellular metabolism contributes to the production of reactive nitrogen intermediates (RNI), and reactive oxygen species (R...
What are the DNA lesions underlying formaldehyde toxicity?
What are the DNA lesions underlying formaldehyde toxicity?
The simplest and most reactive naturally occurring aldehyde is formaldehyde (CH2O). It has been known since the 1940’s tha...
DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
Volume 138, June 2024, 103677Author links open overlay panelJing Ge a, Le P. Ngo a, Simran Kaushal a, Ian J. Tay a, Elina ...
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
The polymerase δ (Polδ) is a critical enzyme responsible for synthesizing nascent DNA strands in the eukaryotic genome [1]...
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
Radiotherapy is one of the key treatment modalities for cancer, responsible for ∼ 50% of cancer cures. DNA damage response...
Genomic stress and impaired DNA repair in Alzheimer disease
Genomic stress and impaired DNA repair in Alzheimer disease
Alzheimer disease (AD) was first described in 1906 by German psychiatrist and neuroanatomist Dr. Alois Alzheimer [1]. In t...
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to ...
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97 (also known as VCP), are essential fo...
The role of rRNA in maintaining genome stability
The role of rRNA in maintaining genome stability
Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled n...
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy
In vitro and in vivo models of lipopolysaccharide (LPS)-induced pulmonary injury, quercetin-3-glucuronide (Q3G) has been p...
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