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Mesenchymal stem cell-based therapy for paraquat-induced lung injury
Mesenchymal stem cell-based therapy for paraquat-induced lung injury
Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairi...
Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates
Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates
Many persistent organic pollutants (POPs) are suspected endocrine disruptors and it is important to investigate their effe...
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse
The simultaneous abuse of alcohol-cocaine is known to cause stronger and more unpredictable cellular damage in the liver, ...
Metal ions overloading and cell death
Metal ions overloading and cell death
Cell death maintains cell morphology and homeostasis during development by removing damaged or obsolete cells. The concent...
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis
Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) have emerged as a new treatment strategy for infla...
Comprehensive mapping of immune perturbations associated with aplastic anemia
Comprehensive mapping of immune perturbations associated with aplastic anemia
Aplastic anemia (AA) is an immune-mediated syndrome characterized by bone marrow failure. Therefore, comprehending the cel...
tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease
tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease
tRNAs are codon decoders that convert the transcriptome into the proteome. The field of tRNA research is excited by the in...
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
Gastrointestinal (GI) cancers are common cancers that are responsible for a large portion of global cancer fatalities. Due...
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
Noise-induced hidden hearing loss (HHL) is a newly uncovered form of hearing impairment that causes hidden damage to the c...
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver damage, highlighting the limitations of current eme...
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis
The N7-methylguanosine (m7G) modification and circular RNAs (circRNAs) have been shown to play important roles in the deve...
Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma
Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma
Tetracaine, a local anesthetic, exhibits potent cytotoxic effects on multiple cancer; however, the precise underlying mech...
ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals
ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals
Angiotensin-converting enzyme 2 (ACE2), a crucial element of the renin-angiotensin system (RAS), metabolizes angiotensin I...
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
Exogenous gaseous formaldehyde (FA) is recognized as a significant indoor air pollutant due to its chemical reactivity and...
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition
Renal interstitial fibrosis (RIF) is a common feature of chronic kidney diseases (CKD), with epithelial-mesenchymal transi...
EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway
EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway
Esophageal squamous cell carcinoma (ESCC) remains a major clinical challenge due to its poor prognosis and the scarcity ef...
Multifaceted roles of mitochondria in asthma
Multifaceted roles of mitochondria in asthma
Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differ...
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance
The high prevalence and detrimental effects on patient outcomes make gastric cancer (GC) a significant health issue that p...
A review of geospatial exposure models and approaches for health data integration
A review of geospatial exposure models and approaches for health data integration
Geospatial methods are common in environmental exposure assessments and increasingly integrated with health data to genera...
Correction: Association between spill-related exposure to fine particulate matter and peripheral motor and sensory nerve function among oil spill response and cleanup workers following the Deepwater Horizon oil spill
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel H...
Applications of mixture methods in epidemiological studies investigating the health impact of persistent organic pollutants exposures: a scoping review
Applications of mixture methods in epidemiological studies investigating the health impact of persistent organic pollutants exposures: a scoping review
Persistent organic pollutants (POPs) are environmental chemicals characterized by long half-lives in nature and human bodi...
Personal air sampling for pesticides in the California San Joaquin Valley
California is a leading agricultural state and with that, has significant applications of pesticides. Levels of exposure h...
Is home where the heat is? comparing residence-based with mobility-based measures of heat exposure in San Diego, California
Is home where the heat is? comparing residence-based with mobility-based measures of heat exposure in San Diego, California
Heat can vary spatially within an urban area. Individual-level heat exposure may thus depend on an individual’s day-...
Human health risk assessment of heavy metals in residential soil—Houston, Texas
Human health risk assessment of heavy metals in residential soil—Houston, Texas
Human health risk assessment increasingly recognizes the need to integrate participatory-based research, geospatial analys...
Evidence for widespread human exposure to food contact chemicals
Evidence for widespread human exposure to food contact chemicals
Over 1800 food contact chemicals (FCCs) are known to migrate from food contact articles used to store, process, package, a...
Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study
Few high-quality studies have evaluated associations between urinary glyphosate or its environmental degradate (aminomethy...
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
This review explores the pivotal role of the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP...
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Mammalian zinc ectopeptidases have significant functions in deactivating neurological and hormonal peptide signals on the ...
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Polyphenolic compounds are among the most widely researched compounds for various therapeutic applications. However, natur...
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
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