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Antinociceptive, anti-inflammatory, and antiophidic potential of leaves extract and fraction: an in vitro and in vivo evaluation
Antinociceptive, anti-inflammatory, and antiophidic potential of leaves extract and fraction: an in vitro and in vivo evaluation
Punica granatum (Punicaceae) is a shrub with a worldwide distribution that has been used in folk medicine for the treatmen...
Anti-inflammatory effects of Calebin A on metabolic syndrome via NF-κB signaling pathway modulation
Anti-inflammatory effects of Calebin A on metabolic syndrome via NF-κB signaling pathway modulation
Metabolic syndrome is a complex disorder characterized by a combination of events such as insulin resistance, obesity, dys...
The hydroalcoholic extract of the leaves of red mombin ( L.) is more effective in accelerating ulcer healing than preventing them in rodents
The hydroalcoholic extract of the leaves of red mombin ( L.) is more effective in accelerating ulcer healing than preventing them in rodents
This study evaluated the anti-ulcer effects of the hydroalcoholic extract from the leaves of Spondias purpurea L. (SPHE). ...
Potentiation of analgesic activity following the complexation of Sobral, Faria & Proença () leaf essential oil with β-cyclodextrin
Potentiation of analgesic activity following the complexation of Sobral, Faria & Proença () leaf essential oil with β-cyclodextrin
Pain is a fundamental biological process; however, its acute manifestation may result in dysregulation and tissue injury. ...
Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli
Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli
Inflammasomes are crucial elements of the innate immune system, responsible for triggering inflammation through the activa...
Targeting mGluR7 in Parkinson’s disease: a novel approach to neuroprotection and synaptic therapies
Targeting mGluR7 in Parkinson’s disease: a novel approach to neuroprotection and synaptic therapies
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in t...
Beyond the blood–brain barrier: unraveling T cell subsets in CNS immunity and disease
Beyond the blood–brain barrier: unraveling T cell subsets in CNS immunity and disease
The complicated interplay between the central nervous system (CNS) and immune system is critical for both neuroprotection ...
Gastroprotective effect of nifuroxazide against indomethacin-induced gastric ulcers in rats via modulation of Nrf2/HO-1, HMGB1/TLR4/NF-κB p65, and apoptotic caspase-3 signaling pathways
Gastroprotective effect of nifuroxazide against indomethacin-induced gastric ulcers in rats via modulation of Nrf2/HO-1, HMGB1/TLR4/NF-κB p65, and apoptotic caspase-3 signaling pathways
Gastric ulcer (GU) is a common gastrointestinal disease linked to the consumption of non-steroidal anti-inflammatory drugs...
Aspirin’s effect on macrophages beyond its chemopreventive role in inflammation and cancer
Aspirin’s effect on macrophages beyond its chemopreventive role in inflammation and cancer
Aspirin's antineoplastic activities are primarily executed by irreversibly prohibiting COX-1 in platelets, hindering p...
Ozone therapy and the role of the glutathione pathway
Ozone therapy and the role of the glutathione pathway
Oxygen-ozone therapy (OOT) represents a multi-target intervention that engages redox modulation, endothelial repair, nitri...
Targeting the cytokine–redox axis: dose-dependent immunomodulation by methotrexate in a biomarker-guided ovine endotoxaemia model
Targeting the cytokine–redox axis: dose-dependent immunomodulation by methotrexate in a biomarker-guided ovine endotoxaemia model
Oxidative stress and excessive inflammation are central to the pathophysiology of sepsis and its large-animal analogue, en...
Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis
Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis
The COVID-19 pandemic has resulted in several long-term complications, with COVID-19-induced pulmonary fibrosis being a si...
L. essential oil attenuates inflammation and pain via TRPV1
L. essential oil attenuates inflammation and pain via TRPV1
Pain and inflammation are complex physiological responses. The drugs that are available in the market have multiple side e...
Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies
Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chro...
Transcription-coupled repair of crosslinking DNA damage
Impediments to faithful transcription must be resolved to ensure accurate gene expression and safeguard normal cellular fu...
"Yin-Yang" of PARP1 in genotoxic and inflammatory response
The poly(ADP-ribose) polymerase superfamily (PARP superfamily) comprises a group of enzymes with ADP-ribosyltransferase (A...
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer
The innate immune sensing system plays a critical role in recognizing and responding to DNA damage, which is a key factor ...
DNA repair at the crossroads of tumor immunogenicity and cancer therapy: Harnessing innate and adaptive immune pathways for improved therapeutic outcomes
Immunotherapy has revolutionized cancer treatment, particularly with immune checkpoint inhibitors (ICIs), which harness th...
Harnessing R-loop dynamics: Challenging cancer therapy resistance
RNA:DNA hybrids are atypical nucleic acid structures that predominantly form during the transcription of RNA, resulting in...
FBH1 and the replication stress response: Implications for genome stability and cancer development
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Base excision repair in human cancer: Emerging diagnostic and therapeutic target
BER is a highly conserved and major DNA repair mechanism [1], [2] which acts like an immune surveillance system for DNA, e...
From cooperation to conflicts – A complicated relationship between transcription and replication
Volume 152, August 2025, 103872Author links open overlay panel, Highlights•Transcription and DNA replication share the DNA...
Multiple functions of PARP1 in the repair of DNA double strand breaks
Poly ADP-ribose polymerase (PARP) proteins directly contribute to a wide range of essential cellular processes, including ...
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres
Volume 152, August 2025, 103876Author links open overlay panel, AbstractDNA resection is a universal process in genome mai...
Cytosolic DNA and intracellular Ca2+: Maintaining genome stability during replication stress
Starting from a single fertilized egg, trillions of rounds of DNA replication must occur during development to generate th...
Corrigendum to “Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer” [DNA Repair 152 (2025) 103868]
Available online 5 August 2025, 103878Author links open overlay panelMin-Guk Cho a, Gaorav P. Gupta a b c d eShow moreReco...
Proofreading exonuclease activities of Polδ and Polε differentially contribute to the removal of chain-terminating nucleoside analogs
Chain-terminating nucleoside analogs (CTNAs) are incorporated into genome during replication by replicative polymerase del...
Contributions of DNA double strand break repair pathways to DNA crosslink repair
DNA crosslink-inducing drugs are widely used in clinical settings for treatment of solid tumors. Double strand breaks (DSB...
S-palmitoylation: An oily modification guardinggenome stability
Genomic stability is essential for the faithful preservation and error-free transmission of genetic information across gen...
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies
Impaired genomic stability is a hallmark of many cancers, with the DNA damage response (DDR) mechanisms serving as critica...
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