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Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies
Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chro...
Transcription-coupled repair of crosslinking DNA damage
Impediments to faithful transcription must be resolved to ensure accurate gene expression and safeguard normal cellular fu...
"Yin-Yang" of PARP1 in genotoxic and inflammatory response
The poly(ADP-ribose) polymerase superfamily (PARP superfamily) comprises a group of enzymes with ADP-ribosyltransferase (A...
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer
The innate immune sensing system plays a critical role in recognizing and responding to DNA damage, which is a key factor ...
DNA repair at the crossroads of tumor immunogenicity and cancer therapy: Harnessing innate and adaptive immune pathways for improved therapeutic outcomes
Immunotherapy has revolutionized cancer treatment, particularly with immune checkpoint inhibitors (ICIs), which harness th...
Harnessing R-loop dynamics: Challenging cancer therapy resistance
RNA:DNA hybrids are atypical nucleic acid structures that predominantly form during the transcription of RNA, resulting in...
FBH1 and the replication stress response: Implications for genome stability and cancer development
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Base excision repair in human cancer: Emerging diagnostic and therapeutic target
BER is a highly conserved and major DNA repair mechanism [1], [2] which acts like an immune surveillance system for DNA, e...
From cooperation to conflicts – A complicated relationship between transcription and replication
Volume 152, August 2025, 103872Author links open overlay panel, Highlights•Transcription and DNA replication share the DNA...
Multiple functions of PARP1 in the repair of DNA double strand breaks
Poly ADP-ribose polymerase (PARP) proteins directly contribute to a wide range of essential cellular processes, including ...
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres
Volume 152, August 2025, 103876Author links open overlay panel, AbstractDNA resection is a universal process in genome mai...
Cytosolic DNA and intracellular Ca2+: Maintaining genome stability during replication stress
Starting from a single fertilized egg, trillions of rounds of DNA replication must occur during development to generate th...
Corrigendum to “Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer” [DNA Repair 152 (2025) 103868]
Available online 5 August 2025, 103878Author links open overlay panelMin-Guk Cho a, Gaorav P. Gupta a b c d eShow moreReco...
Proofreading exonuclease activities of Polδ and Polε differentially contribute to the removal of chain-terminating nucleoside analogs
Chain-terminating nucleoside analogs (CTNAs) are incorporated into genome during replication by replicative polymerase del...
Contributions of DNA double strand break repair pathways to DNA crosslink repair
DNA crosslink-inducing drugs are widely used in clinical settings for treatment of solid tumors. Double strand breaks (DSB...
S-palmitoylation: An oily modification guardinggenome stability
Genomic stability is essential for the faithful preservation and error-free transmission of genetic information across gen...
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies
Impaired genomic stability is a hallmark of many cancers, with the DNA damage response (DDR) mechanisms serving as critica...
Insight into meiotic DNA end resection: Mechanisms and regulation
Volume 153, September 2025, 103886Author links open overlay panel, , , AbstractMeiosis generates reproductive cells with a...
The B cell dilemma: Diversity or fidelity?
Volume 153, September 2025, 103888Author links open overlay panel, , AbstractThe ability of B lymphocytes to diversify imm...
Innate immune sensing and signaling: Co-opted for genome surveillance? Implications for tumorigenesis
Volume 153, September 2025, 103890Author links open overlay panel, AbstractInnate immune signaling is traditionally associ...
Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
The contamination of N-nitrosamines (N-NAs) in pharmaceuticals has raised global concerns, due to potential carcinogenic r...
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
The widespread use of pesticides is increasing the presence of environmental contaminants with potential impacts on biodiv...
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings p...
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3 (GSK-3) is a critical serine/threonine kinase that plays a central role in regulating various c...
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Cell Painting visualizes toxicity-induced morphological changes by staining cellular structures with fluorescent dyes. Cou...
Construction of testicular organoids and their applications in the field of toxicology
Construction of testicular organoids and their applications in the field of toxicology
The decline in male sperm quality significantly contributes to infertility among couples of reproductive age, threatening ...
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
Alzheimer’s disease (AD), a neurodegenerative “memory killer” demanding urgent global intervention, has ...
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Phthalates (PAEs) are well-recognized endocrine-disrupting compounds. Despite their established status as such, the associ...
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
Polygonum multiflorum (PM) has been reported to cause immune-mediated idiosyncratic liver injury. 2,3,5,4’-tetrahydr...
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Organophosphate esters (OPEs), commonly used as flame retardants and plasticizers, are ubiquitous environmental contaminan...
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