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PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to cidofovir
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Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions
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MeCP2 deficiency leads to the γH2AX nano foci expansion after ionizing radiation
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The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response
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Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants
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The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions
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DNAR special issue: DNA damage responses and neurological disease The DNA damage response and neurological disease
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The interferon response at the intersection of genome integrity and innate immunity
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Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation
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Mechanisms of tandem duplication in the cancer genome
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Corrigendum to “BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination” [DNA Repair 115 (2022) 103331]
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Small-Molecule Activator of SMUG1 Enhances Repair of Pyrimidine Lesions in DNA
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The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm
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Cutting edge perspectives in genome maintenance XI
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Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique
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Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays
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USP1 in regulation of DNA repair pathways
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The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics
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In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic ...
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
The tumorigenic dose 50 (TD50) is a widely used measure of carcinogenic potency which has historically been used to determ...
Re-thinking the link between exposure to mercury and blood pressure
Re-thinking the link between exposure to mercury and blood pressure
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant c...
Elucidating the Phase I metabolism of psilocin in vitro
Elucidating the Phase I metabolism of psilocin in vitro
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps rema...
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances...
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical r...
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
The potential risk of chemicals to the human eye is assessed by adopted test guidelines (TGs) for regulatory purposes to e...
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.cig vapi...
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious a...
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlo...
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relativ...
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Little is known about the impact of environmental pollution on thyroid function in the non-occupationally exposed populati...
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