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Differential expression of endothelial derived galectins in response to shear stress
BackgroundEndothelial cells function as mechanosensors, dynamically altering their functional response based on varying sh...
Human umbilical cord mesenchymal stem cell-derived exosome ameliorate doxorubicin-induced senescence
Delaying aging and discovering anti-aging therapeutics are among the primary goals of modern biomedical research. Aging oc...
PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination
Ovarian cancer (OC) is the second most common cause of death from gynecological tumors in women worldwide, inferior to cer...
Estrogen receptor β alleviates colitis in intestinal epithelial cells and activates HIF-1a and ATG-9a-mediated autophagy
Ulcerative colitis (UC), a predominant form of inflammatory bowel disease (IBD), is a chronic and relapsing intestinal inf...
FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation
Oocyte quality significantly impacts female fertility, influencing sperm-egg interaction, early embryonic development, and...
CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1β pathway
Diabetic retinopathy (DR), a prevalent microvascular progressive complication of diabetes mellitus (DM), serves as a major...
Oxytocin receptor enhances adipocyte browning and energy metabolism in mice
Obesity, a pathological accumulation of body fat, is a global health concern linked to cardiovascular disease, diabetes, i...
Calcium sensing receptor stimulates breast cancer cell migration and invasion via protein kinase C ζ
The calcium-sensing receptor (CaSR), a member of the class-C G protein-coupled receptor family, is known to be expressed i...
CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis
The datasets generated and analyzed during the current study are available from the corresponding author on reasonable req...
lncRNA NR_146969 promotes the progression of lung adenocarcinoma
Cancer is the leading cause of death in humans, seriously hindering people's hopes for longevity. At the forefront is lung...
Bifidobacterium adolescentis prevents diabetes-induced liver injury via pyroptosis attenuation
Nonalcoholic fatty liver disease (NAFLD), characterized by inflammation and hepatocyte ballooning, ranks among the most pr...
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity
Ethanol (EtOH)-induced cardiotoxicity (EIC) can significantly damage cardiomyocytes and compromise cardiac function, final...
Biomarkers for the detection of circulating tumor cells
Circulating tumor cells (CTCs) have emerged as a key biomarker in cancer detection and prognosis, and their molecular prof...
Irradiation of 125I seeds blocks glycolysis in pancreatic cancer by inhibiting KLF5 m6A methylation through the suppression of RBM15
This paper investigated whether 125I seed irradiation for pancreatic cancer treatment was mediated through the RBM15/KLF5 ...
Increased oxidative stress and autophagy in NGLY1 patient iPSC-derived neural stem cells
Volume 448, Issue 1, 1 May 2025, 114540Author links open overlay panel, , , , , , Highlights•NGLY1 deficient neural stem c...
GW806742X can induce mouse MLKL activation by directly promoting MLKL kinase like domain dimerization
Necroptosis is a regulated, caspase-independent form of necrotic cell death driven by the kinases RIPK1 and RIPK3, which s...
ETS1 modulates ferroptosis to affect the process of myocardial ischemia-reperfusion injury via PIM3
Myocardial ischemia-reperfusion injury (MIRI) is a complex physiological and pathological process that may occur after the...
Creation of a rat model of ovarian endometriosis: a novel and easy approach to simulating chocolate cysts
Firstly, this is the first study to construct ovarian endometriosis by inserting uterine tissue into ovarian adipose tissu...
Type III sodium-dependent inorganic phosphate transporters are required for the phenotypes in human brain microvascular endothelial cells
Inorganic phosphate (Pi) is required for cellular function. It is required for kinase signaling, DNA and lipid formation a...
Evaluation of the impact of miR-3143 on the PI3K/AKT signaling pathway and its subsequent influence on the metastatic phenotype of triple-negative breast cancer cells
In recent years, cancer has threatened human life and health, emerging as a predominant source of mortality globally [1]. ...
Excess glucose alone induces hepatocyte damage due to oxidative stress and endoplasmic reticulum stress
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Comprehensive analysis of the m6A demethylase FTO in endothelial dysfunction by MeRIP sequencing
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Exercise training alleviates cholesterol and lipid accumulation in mice with non-alcoholic steatohepatitis: Reduction of KMT2D-mediated histone methylation of IDI1
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Long noncoding RNA UCA1 inhibits epirubicin-induced apoptosis by activating PPARα-mediated lipid metabolism
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Screening lncRNAs essential for cardiomyocyte proliferation by integrative profiling of lncRNAs and mRNAs associated with heart development
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PANX2 promotes malignant transformation of colorectal cancer and 5-Fu resistance through PI3K-AKT signaling pathway
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Heterogeneity in extracellular matrix and immune microenvironment of anterior vaginal wall revealed by single-cell sequencing in women with stress urinary incontinence
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In vitro obtainment of stem-like cells from gubernaculum testis biopsies of cryptorchid pediatric patients
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Changes and significance of Th1/Th2 and Treg/Th17 cells and their cytokines in patients with alopecia areata
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Role and mechanism of histone demethylase PHF8 in weightlessness osteoporosis
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