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Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182
Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182
Osteoarthritis (OA) is the most common type of joint disease worldwide, characterized by joint pain, and limited mobility....
ICBP90, an epigenetic regulator, induces DKK3 promoter methylation, promotes glioma progression, and reduces sensitivity to cis-platinum
ICBP90, an epigenetic regulator, induces DKK3 promoter methylation, promotes glioma progression, and reduces sensitivity to cis-platinum
Glioma is the most common primary tumor in central nervous system neoplastic diseases, often manifested as high malignancy...
Effect of sodium butyrate treatment at the basolateral membranes on the tight junction barrier function via a monocarboxylate transporter in goat mammary epithelial cells
Effect of sodium butyrate treatment at the basolateral membranes on the tight junction barrier function via a monocarboxylate transporter in goat mammary epithelial cells
Mammary epithelial cells (MECs) have a distinct cell polarity, which is important for milk production during lactation. ME...
Identification of necroptosis-associated miRNA signature for predicting prognosis and immune landscape in stomach adenocarcinoma
Identification of necroptosis-associated miRNA signature for predicting prognosis and immune landscape in stomach adenocarcinoma
PurposeThis study aims to identify the potential necroptosis related genes (NRGs)-associated miRNAs signature and explore ...
The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma
The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma
Enhancer of Zeste Homolog 1 (EZH1) and Enhancer of Zeste Homolog 2 (EZH2) are the key components of polycomb repressive co...
Acidity-induced ITGB6 promote migration and invasion of lung cancer cells by epithelial-mesenchymal transition and focal adhesion
Acidity-induced ITGB6 promote migration and invasion of lung cancer cells by epithelial-mesenchymal transition and focal adhesion
Lung cancer is one of the most frequent cancers worldwide, being categorized as small cell carcinoma or non-small cell car...
Amyloid β interferes with wound healing of brain microvascular endothelial cells by disorganizing the actin cytoskeleton
Amyloid β interferes with wound healing of brain microvascular endothelial cells by disorganizing the actin cytoskeleton
Alzheimer's disease (AD) is a neurodegenerative disease and progressive disorder of the brain that gradually decreases thi...
scaRNA20 promotes pseudouridylatory modification of small nuclear snRNA U12 and improves cardiomyogenesis
scaRNA20 promotes pseudouridylatory modification of small nuclear snRNA U12 and improves cardiomyogenesis
Ischemic heart disease (IHD) is a leading cause of death for people worldwide, affecting approximately 126 million individ...
Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma
Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma
Patients with hepatocellular carcinoma (HCC) are vulnerable to drug resistance. Although drug resistance has been taken mu...
Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest
Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest
Kinesin superfamily proteins (KIFs) are evolutionary conserved microtubule-associated proteins involved in diverse cellula...
MARCH-I: A negative regulator of dendritic cell maturation
MARCH-I: A negative regulator of dendritic cell maturation
The considerable role of DCs as a functional interface between innate and acquired immunity as well as the most important ...
Corrigendum to “MEX3A promotes development and progression of breast cancer through regulation of PIK3CA” [Exp. Cell Res. 2021 Jul 1;404(1):112580. Epub 2021 Apr 1.]
Corrigendum to “MEX3A promotes development and progression of breast cancer through regulation of PIK3CA” [Exp. Cell Res. 2021 Jul 1;404(1):112580. Epub 2021 Apr 1.]
Volume 436, Issue 1, 1 March 2024, 113964Author links open overlay panelXianbiao Shi a, Yulu Sun b, Yin Zhang a, Wei Wang ...
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Intracerebral hemorrhage (ICH) can lead to the loss of neuronal cells through the response to the hematoma and the release...
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Miscarriage, also termed spontaneous abortion, is one of the most frequent complications during gestation, and approximate...
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Hypospadias is a congenital external genital malformation in which the urethral folds are incompletely fused, resulting in...
Botulinum toxin type a blocks aquaporin 5 trafficking by decreasing synaptosomal-associated protein 23 in submandibular acinar cells
Botulinum toxin type a blocks aquaporin 5 trafficking by decreasing synaptosomal-associated protein 23 in submandibular acinar cells
Aquaporin 5 (AQP5) is a water channel protein that modulates transcellular water permeability and plays an important role ...
The m6A methyltransferase RBM15 affects tumor cell stemness and progression of cervical cancer by regulating the stability of lncRNA HEIH
The m6A methyltransferase RBM15 affects tumor cell stemness and progression of cervical cancer by regulating the stability of lncRNA HEIH
Cervical cancer (CC), as a common female malignant tumor in the world, is an important risk factor endangering the health ...
RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway
RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway
Osteosarcoma (OS) is one of the most common malignant bone tumors in children and adolescents, accounting for approximatel...
Corrigendum to TWIST2 inhibits EMT and induces oxidative stress of lung cancer cells by regulating FGF21-mediated AMPK/mTOR pathway [Exp. Cell Res. 2021 Aug 1;405(1):112661/ECR-21-80]
Corrigendum to TWIST2 inhibits EMT and induces oxidative stress of lung cancer cells by regulating FGF21-mediated AMPK/mTOR pathway [Exp. Cell Res. 2021 Aug 1;405(1):112661/ECR-21-80]
Volume 436, Issue 2, 15 March 2024, 113782Author links open overlay panelYingjian Song a 1, Wei Zhang a 1, Jiuxu Zhang b, ...
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
As the primary cause of cancer-related deaths, cancer metastasis is a complicated process in which multiple signal pathway...
LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer
LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer
Genetic factors coordinate with environmental factors to drive the pathogenesis of prostate adenocarcinoma (PRAD). SPOP is...
Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes
Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes
ObjectiveA wide range of cardiac diseases is associated with inflammation. “Inflamed” heart tissue is infiltrated with pro...
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells
Liver cirrhosis (LC) is a serious health problem worldwide, and the only therapeutic option is orthotopic liver transplant...
Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling pathway
Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling pathway
Liver cancer stem cells (LCSCs) constitute a distinct subset within liver cancer, possessing the remarkable ability of sel...
Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy
Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy
Epilepsy is a neurological disorder characterized by recurrent seizures, resulting from abnormal brain activity [1]. Vario...
miR-130b regulates B cell proliferation via CYLD-mediated NF-κB signaling
miR-130b regulates B cell proliferation via CYLD-mediated NF-κB signaling
B cells play an important role in host immunity. B cell activation is initiated by the antigen recognition of the B cell r...
Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice
Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice
The intestinal barrier, comprised of a mucus layer (chemical barrier), cell layer (mechanical barrier), and lamina propria...
Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells
Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells
Breast cancer is the most common cancer in women. The upregulation of insulin-like growth factor (IGF) system observed in ...
Advances in bi-directional relationships for EZH2 and oxidative stress
Advances in bi-directional relationships for EZH2 and oxidative stress
Over the past two decades, polycomb repressive complex 2(PRC2) has emerged as a vital repressive complex in overall cell f...
Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells
Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells
Intracellular lipid droplets (LDs) are ubiquitous organelles found in many cell types. During mitosis, membranous organell...
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