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Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. Th...
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
5-Fluorouracil (5-FU) is an antimetabolite chemotherapeutic agent that can cause oxidative stress and complications in nor...
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Obesity has emerged as a major health challenge globally in the last two decades. Dysregulated fatty acid metabolism and d...
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Cur...
Cellular and molecular aspects of drug resistance in cancers
Cellular and molecular aspects of drug resistance in cancers
Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellul...
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vag...
Trends analysis and future study of the pharmaceutical industry field: a scoping review
Trends analysis and future study of the pharmaceutical industry field: a scoping review
The main aim of this study was to explore and understand the emerging developments, changes, and patterns shaping the futu...
Electroceuticals: Unlocking the promise of therapies
Electroceuticals: Unlocking the promise of therapies
Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a...
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for qua...
Epitope profiling of cow's milk allergen-specific antibodies with determining IgE content in epitopes-ALL, a 14-epitopes mixture
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Isolation of anti-Ancylostoma-secreted protein 5 (ASP5) antibody from a naïve antibody phage library
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Inducing and regulating human naive CD4+ T cell proliferation by different antigen presenting cells
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Plaque reduction neutralization test for smallpox vaccines: Laboratory optimization and validation method for immunogenicity assessment
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Natural cross-reactive anti-SARS-CoV-2 antibodies in avian egg yolk
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Adaptation of the in vivo respiratory burst assay for fathead minnow larvae (Pimephales promelas)
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Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera
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Retraction Note: Disruption of lipid-raft localized Gαs/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds
Authors and AffiliationsDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, 60612, US...
The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice
The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice
Chronic stress induces neural dysfunctions and risks mental illnesses. Clinical and preclinical studies have established t...
Genome-wide methylome-based molecular pathologies associated with depression and suicide
Genome-wide methylome-based molecular pathologies associated with depression and suicide
Major depressive disorder (MDD) is a debilitating disorder. Suicide attempts are 5-times higher in MDD patients than in th...
The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial
The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial
New combinations or alternative therapies for major depressive disorder (MDD) are necessary. Intradermal acupuncture (IA) ...
Correction: The might of light for revealing neuropsychiatric mechanisms
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Neural basis of adolescent THC-induced potentiation of opioid responses later in life
Neural basis of adolescent THC-induced potentiation of opioid responses later in life
Use of one addictive drug typically influences the behavioral response to other drugs, either administered at the same tim...
Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants
Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants
N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that is known for its short-lasting effects when administered i...
Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving
Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving
The accumulation of GluA2-lacking Ca2+-permeable AMPARs (CP-AMPARs) in the medium spiny neurons (MSNs) of the nucleus accu...
Cefiderocol susceptibility of 146 Stenotrophomonas maltophilia strains clinically isolated from blood in two Japanese hospitals over a 10-year period
Cefiderocol susceptibility of 146 Stenotrophomonas maltophilia strains clinically isolated from blood in two Japanese hospitals over a 10-year period
Previous reports focusing on cefiderocol susceptibility against Stenotrophomonas maltophilia have included a large number ...
Evaluation of different standard and modified two-tier testing strategies for the laboratory diagnosis of lyme borreliosis in a European setting
Evaluation of different standard and modified two-tier testing strategies for the laboratory diagnosis of lyme borreliosis in a European setting
Diagnosis of Lyme borreliosis (LB) relies on clinical symptoms and detection of Borrelia-specific antibodies. Guidelines r...
A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations
A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations
Human papillomavirus (HPV) infections are the leading cause of cervical cancer, the fourth most common cancer among women ...
Several epidemic and multiple sporadic genotypes of OXA-244-producing Escherichia coli in Poland; predominance of the ST38 clone
Several epidemic and multiple sporadic genotypes of OXA-244-producing Escherichia coli in Poland; predominance of the ST38 clone
OXA-244-producing Escherichia coli (OXA-244-Ec) has disseminated in Europe, mostly in the community. In Poland it has spre...
Detection of community-acquired respiratory viruses during COVID-19 pandemic in subtropical region in Japan
Detection of community-acquired respiratory viruses during COVID-19 pandemic in subtropical region in Japan
Coronavirus disease 2019 (COVID-19) pandemic changed the dynamics of other community-acquired respiratory viruses (CARVs),...
Validation of MEWS, NEWS, NEWS-2 and qSOFA for different infection foci at the emergency department, the acutelines cohort
Validation of MEWS, NEWS, NEWS-2 and qSOFA for different infection foci at the emergency department, the acutelines cohort
Sepsis is a leading cause of morbidity and mortality globally. The lack of specific prognostic markers necessitates tools ...
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