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Association of exercise-induced pulmonary hypertension with nailfold capillary density in systemic sclerosis: a single-center retrospective observational study
Association of exercise-induced pulmonary hypertension with nailfold capillary density in systemic sclerosis: a single-center retrospective observational study
Exercise-induced pulmonary hypertension (exercise PH) is instrumental in the early detection of pulmonary arterial hyperte...
Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
Cadherins (CDH), such as CDH11, are glycoprotein adhesion molecules contributing to cell-cell interactions in health and d...
Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)
Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)
Systemic sclerosis (SSc) is an autoimmune disease, which is characterized by fibrosis of the skin, progressing to affect t...
The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren’s Disease: a prospective monocentric study
The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren’s Disease: a prospective monocentric study
To evaluate the diagnostic accuracy of salivary gland ultrasound (SGUS) in patients with high suspicion of Sjögren...
A 6-year prospective study on work participation and the associated factors in Dutch patients with systemic lupus erythematosus (SLE)
A 6-year prospective study on work participation and the associated factors in Dutch patients with systemic lupus erythematosus (SLE)
Previous studies showed that many patients with SLE do not have paid work. However, having paid work is important for self...
Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
Quantitative genotoxicity assessment of -nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination
The contamination of N-nitrosamines (N-NAs) in pharmaceuticals has raised global concerns, due to potential carcinogenic r...
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations
The widespread use of pesticides is increasing the presence of environmental contaminants with potential impacts on biodiv...
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene
Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings p...
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease
Glycogen synthase kinase-3 (GSK-3) is a critical serine/threonine kinase that plays a central role in regulating various c...
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment
Cell Painting visualizes toxicity-induced morphological changes by staining cellular structures with fluorescent dyes. Cou...
Construction of testicular organoids and their applications in the field of toxicology
Construction of testicular organoids and their applications in the field of toxicology
The decline in male sperm quality significantly contributes to infertility among couples of reproductive age, threatening ...
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease
Alzheimer’s disease (AD), a neurodegenerative “memory killer” demanding urgent global intervention, has ...
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy
Phthalates (PAEs) are well-recognized endocrine-disrupting compounds. Despite their established status as such, the associ...
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by
Polygonum multiflorum (PM) has been reported to cause immune-mediated idiosyncratic liver injury. 2,3,5,4’-tetrahydr...
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells
Organophosphate esters (OPEs), commonly used as flame retardants and plasticizers, are ubiquitous environmental contaminan...
Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology
Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology
Traditional toxicological paradigms, reliant on animal testing and simplistic in vitro models, face significant limitation...
In vitro metabolic profiling and structure–metabolism relationships of substituted acetyl fentanyl-type new psychoactive substances
In vitro metabolic profiling and structure–metabolism relationships of substituted acetyl fentanyl-type new psychoactive substances
The abuse of fentanyl-type new psychoactive substances (F-NPS), which exhibit the four defining characteristics of new psy...
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Cellular systems responsible for the formation and removal of reactive oxygen species (ROS), functioning within physiologi...
Immunomodulatory effects of the herbicide glyphosate following occupational exposure
Immunomodulatory effects of the herbicide glyphosate following occupational exposure
Glyphosate, a widely used herbicide, has raised concerns regarding its impact on human health and the environment due to i...
News and views: lysine sorbylation enters the expanding universe of posttranslational modifications
News and views: lysine sorbylation enters the expanding universe of posttranslational modifications
Opinion Letter to Sin et al (Science Advances, 2025), Sorbate induces lysine sorbylation through noncanonical activities o...
Epstein-Barr virus (EBV) infection and its sequelae in the immunocompetent host
Epstein-Barr virus (EBV) was discovered in 1964 by using electron microscopy to visualize the viral particles in B lymphoc...
Differential severity of SARS-CoV-2 variant infections in children and adults with COVID-19
Continual mutations in the SARS coronavirus 2 (SARS-CoV-2) genome over time have led to the emergence of waves of infectio...
Emergence of Parechovirus-A5 central nervous system infections in children from Kansas City, Missouri, USA
The Parechovirus genus includes six species (A-F), with only Parechovirus-A (PeV-A) species infecting humans. To date, 19 ...
Clinical evaluation of Xpert HIV Qual XC assay in diverse HIV-1 subtypes circulating in China
Volume 180, October 2025, 105844Author links open overlay panel, , , , , , , , , Highlights●99.07 % sensitivity & 100....
Clinical performance of the BD Onclarity™ HPV extended genotyping assay for anal cancer screening: a prospective pilot study
Anna Daniela Iacobone: Writing – review & editing, Writing – original draft, Validation, Supervision, Investigation, F...
SpikeID: Rapid and unbiased identification of SARS-CoV-2 variants by spike sequencing
Volume 180, October 2025, 105845Author links open overlay panel, , , , , , , , , , , , , Highlights●SpikeID is a sequence-...
The Allplex HPV HR Detection assay fulfils international guideline requirements for primary cervical screening on SurePath samples and qualifies as a second-generation HPV comparator test
A key parameter for the continued success of cervical cancer screening is quality-controlled use of human papillomavirus (...
Pathogen surveillance of acute conjunctivitis reveals recent emergence of coxsackievirus A24 variants and high genotypic diversity of human adenoviruses in Shenzhen, China, 2018–2024
Acute conjunctivitis caused mainly by viral pathogens is an extremely frequent ophthalmological disease in people of all a...
Heterogeneity of false reactivity profiles of HIV assays while optimizing national HIV testing algorithms: Findings from a multi-country analysis
The datasets generated and/or analyzed during the present study are available on reasonable request from/to the correspond...
Comparison of diagnostic performances of HDV-RNA quantification assays used in clinical practice: Results from a national quality control multicenter study
Volume 180, October 2025, 105850Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights●The assay...
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