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An Investigation of the Levels of Serine Protease and Associated Molecules in Children with Autism Spectrum Disorder
An Investigation of the Levels of Serine Protease and Associated Molecules in Children with Autism Spectrum Disorder
This study aimed to elucidate the potential role of serine proteases and their associated regulatory molecules in the etio...
The ADNP-Mediated Transcriptome Response to Ketamine Impairs the Cytoskeletal Protein Axis
The ADNP-Mediated Transcriptome Response to Ketamine Impairs the Cytoskeletal Protein Axis
De novo variants in the Activity-Dependent Neuroprotective Protein (ADNP) gene cause the autistic Helsmoortel-Van der Aa s...
Exosome/Extracellular Vesicles-Based Therapeutics in Alzheimer’s Disease: Neuroprotective Roles and Future Perspectives
Exosome/Extracellular Vesicles-Based Therapeutics in Alzheimer’s Disease: Neuroprotective Roles and Future Perspectives
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by memory loss, cognitive decline, and...
Transcriptome Profiling Across Multiple Organs Unveils Potential Regulatory Effects of C-Fibers on Host in Mice
Transcriptome Profiling Across Multiple Organs Unveils Potential Regulatory Effects of C-Fibers on Host in Mice
As nociceptors, C-fibers play a critical role in maintaining host homeostasis under both physiological and pathological co...
Targeting Oligodendrocyte Dysfunction in Alzheimer’s Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists
Targeting Oligodendrocyte Dysfunction in Alzheimer’s Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists
Emerging data highlight oligodendrocyte dysfunction and myelin degeneration as early contributors to the pathology of Alzh...
An Investigation of the Causal Link Between Palmoylation Genes and Epilepsy Utilising Multi-omics Mendelian Randomisation Analysis and Validation Through Single-Cell Evidence
An Investigation of the Causal Link Between Palmoylation Genes and Epilepsy Utilising Multi-omics Mendelian Randomisation Analysis and Validation Through Single-Cell Evidence
This work sought to examine the causal link between palmoyl-protein-modifying genes (ZDHHC family) and epilepsy by Mendeli...
Investigating the Genetic Diversity of DRD2 and OXTR Genes in the Iranian Population and Its Relationship with Personality Traits
Investigating the Genetic Diversity of DRD2 and OXTR Genes in the Iranian Population and Its Relationship with Personality Traits
By analyzing genetic polymorphisms in the genes of patients and control subjects, it is possible to find the correlation o...
The Causal Relationship Between Palmitoylation Genes and Parkinson’s Disease: A Mendelian Randomization Study
The Causal Relationship Between Palmitoylation Genes and Parkinson’s Disease: A Mendelian Randomization Study
This work examined the causal link between palmitoylation-related genes and Parkinson’s disease (PD) by Mendelian ra...
Piperine Prevents Scopolamine-Induced Cognitive Impairment via its Antioxidant and Anti-Inflammatory Roles; Suggesting Potential Modulation of Necroptosis-Related Genes Including MLKL and TNF-α
Piperine Prevents Scopolamine-Induced Cognitive Impairment via its Antioxidant and Anti-Inflammatory Roles; Suggesting Potential Modulation of Necroptosis-Related Genes Including MLKL and TNF-α
Alzheimer's disease (AD) is the leading cause of dementia, characterized by cognitive decline and neurodegeneration. G...
LncRNA MYL2 Acts as a Sponge for miR-661 to Regulate Postoperative Cognitive Dysfunction
LncRNA MYL2 Acts as a Sponge for miR-661 to Regulate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) has a significant impact on the postoperative life ability of the elderly, and ...
Unconventional Non-rodent Models in Neurological Research: Exploring New Paths to Translational Insights
Unconventional Non-rodent Models in Neurological Research: Exploring New Paths to Translational Insights
Neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease ...
Cannabinoids and ADHD: a New Frontier in Neuropharmacology?
Cannabinoids and ADHD: a New Frontier in Neuropharmacology?
Attention deficit hyperactivity disorder (ADHD) is a disorder characterized by symptoms of inattention, impulsivity, and h...
-Related Disorders in Seven New Patients: Refining the Phenotypic Spectrum and Insights on Phenotype-Genotype Correlations
-Related Disorders in Seven New Patients: Refining the Phenotypic Spectrum and Insights on Phenotype-Genotype Correlations
Pathogenic variants in EPG5 have been associated with Vici syndrome (OMIM #242840) characterized by agen...
Microglial Necroptosis Mediated by RIPK3 Leads to Retinal Ganglion Cell Apoptosis Through the Release of FGF2 After Ischemia/Reperfusion
Microglial Necroptosis Mediated by RIPK3 Leads to Retinal Ganglion Cell Apoptosis Through the Release of FGF2 After Ischemia/Reperfusion
The aim of this study was to explore the function of receptor-interacting protein kinase 3 (RIPK3) on retinal neuron damag...
Phytosterols from Rosaceae Species as Dual Modulators of Neuroinflammation and Induced Pluripotency
Phytosterols from Rosaceae Species as Dual Modulators of Neuroinflammation and Induced Pluripotency
Neuroinflammation is a central pathological hallmark of numerous neurodegenerative disorders, often linked to oxidative st...
Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury
Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury
Spinal cord injury (SCI), a traumatic type of central nervous system injury, is closely associated with neuronal apoptosis...
Targeting the Gut-Brain Axis Through Insulin-like Growth Factors: Therapeutic Implications and Future Directions
Targeting the Gut-Brain Axis Through Insulin-like Growth Factors: Therapeutic Implications and Future Directions
The gut-brain axis represents a sophisticated bidirectional communication network connecting the gastrointestinal tract an...
Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome
Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome
Patients with schizophrenia (SCZ) exhibit a significantly higher prevalence of metabolic syndrome (MetS), suggesting a pot...
Hypocitrullinemia as an Early Diagnostic Biomarker for Mitochondrial Diseases
Hypocitrullinemia as an Early Diagnostic Biomarker for Mitochondrial Diseases
MT-ATP6 mitochondrial diseases are a group of disorders inherited from the maternal lineage caused by pathogenic variants ...
Accuracy of a novel ultrasound biomicroscope for measuring corneal epithelial thickness and agreement with an SD-OCT based device
This study evaluates the repeatability and reproducibility of the Insight 100 VHF-UBM in both healthy and post-T-PRK eyes,...
Macular thickness is associated with pathologically confirmed diabetic nephropathy
MethodsThis study included adult patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) who had un...
SpecNet: A hyperspectral band-learning method for slice-level differentiation of fibroadenoma and phyllodes tumor
ObjectiveThis retrospective single-center study aimed to explore the discriminative potential of visible–near-infrared (40...
Improvement of antibacterial potency of riboflavin mediated photodynamic therapy by potassium iodide against Aggregatibacter actinomycetemcomitans biofilm formed on orthodontic miniscrews: An in vitro study
Volume 56, December 2025, 105268Author links open overlay panel, , , , Highlights•The addition of potassium iodide (KI) en...
Machine learning predictive model based on the corneal biomechanics of clinical data
Volume 56, December 2025, 105262Author links open overlay panelHighlight•Collected multidimensional preoperative and posto...
Antimicrobial blue light reduced the growth of Pseudomonas aeruginosa and activated glyoxylate cycle and denitrification
Volume 56, December 2025, 105276Author links open overlay panel, , , , , Highlights•Antimicrobial blue light reduced the n...
Corneal epithelial remodeling following myopic ray-tracing-guided laser-assisted in situ keratomileusis: A clinical study
Volume 56, December 2025, 105257Author links open overlay panel, , , , , , , , , , , Highlights•First mapping of epithelia...
The effect of two different types of daily disposable monofocal contact lenses on ocular wavefront aberrations
MethodsThis study included 34 eyes from 17 patients aged 18 to 40 years (mean age: 27.12±8.3 years) with identical myopic ...
Half-time photodynamic therapy for serous pigment epithelium detachment: anatomical and functional outcomes
Volume 56, December 2025, 105269Author links open overlay panel, , , , , , , Highlights•HtPDT effectively treats serous PE...
Topographic correlation of retinal vascularity and electrophysiology in Nepalese high myopes: Insights for early detection and monitoring
BackgroundmfERG and OCTA parameters have been widely used in myopes to study retinal changes in the myopic retina. However...
Integrating novel OCT-based choroidal imaging: A multimodal nomogram for predicting intravenous glucocorticoid response in thyroid-associated ophthalmopathy
PurposeThis study aimed to develop a clinically accessible, cost-effective nomogram model to predict intravenous glucocort...
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