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Passive leg raising uncovers venous congestion: dynamic fluid intolerance and the Doppler Starling curve
Passive leg raising uncovers venous congestion: dynamic fluid intolerance and the Doppler Starling curve
First, Morosanu explicitly enrolled only patients with a ‘safe’ and, potentially, ‘effective’ profile as the 40 included h...
Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial
Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial
Postextubation respiratory failure (PRF) frequently complicates weaning from mechanical ventilation and may increase morbi...
The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II
The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II
Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex and early phenomenon w...
Critical thresholds of long-pressure reactivity index and impact of intracranial pressure monitoring methods in traumatic brain injury
Critical thresholds of long-pressure reactivity index and impact of intracranial pressure monitoring methods in traumatic brain injury
Moderate-to-severe traumatic brain injury (TBI) has a global mortality rate of about 30%, resulting in acquired life-long ...
Mechanical versus manual cardiopulmonary resuscitation (CPR): an umbrella review of contemporary systematic reviews and more
Mechanical versus manual cardiopulmonary resuscitation (CPR): an umbrella review of contemporary systematic reviews and more
High-quality cardiopulmonary resuscitation (CPR) can restore spontaneous circulation (ROSC) and neurological function and ...
Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study
Alteration in early resting‑state functional MRI activity in comatose survivors of cardiac arrest: a prospective cohort study
This study aimed to explore the characteristics of abnormal regional resting-state functional magnetic resonance imaging (...
Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images
Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images
This study aimed to develop an automated method to measure the gray-white matter ratio (GWR) from brain computed tomograph...
Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest
Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest
The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurologi...
Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which refle...
Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies
Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies
Anemia is a hallmark of critical illness, which is largely inflammatory driven. We hypothesized that the use of anti-infla...
Early administration of high protein for critically ill patients with acute kidney injury?
Early administration of high protein for critically ill patients with acute kidney injury?
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Reflections from the bedside: a nursing perspective on three decades of intensive care
Reflections from the bedside: a nursing perspective on three decades of intensive care
Since critical care’s inception in the 1950s, nursing has been central in its development. Critical care nurses were and r...
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted in...
Do critical illness survivors with multimorbidity need a different model of care?
Do critical illness survivors with multimorbidity need a different model of care?
There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous...
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtrat...
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, wit...
Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients
Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Targeting the host response in sepsis: current approaches and future evidence
Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death wo...
Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockabl...
Critical illness among patients experiencing homelessness: a retrospective cohort study
Critical illness among patients experiencing homelessness: a retrospective cohort study
To understand the epidemiology and healthcare use of critically ill patients experiencing homelessness compared to critica...
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis
Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its pred...
Iron as an emerging therapeutic target in critically ill patients
Iron as an emerging therapeutic target in critically ill patients
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases...
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study
To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients. In t...
Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leadi...
Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes
Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-po...
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest. We po...
Effects of lower versus higher oxygen targets on out-of-hospital cardiac arrest
Effects of lower versus higher oxygen targets on out-of-hospital cardiac arrest
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critica...
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