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Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1
Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1
CC is one of the most common types of cancers in women, and for advanced CC, the median survival is a mere 16.8 months [6]...
Unlocking the ‘ova’-coming power: immunotherapy’s role in shaping the future of ovarian cancer treatment
Unlocking the ‘ova’-coming power: immunotherapy’s role in shaping the future of ovarian cancer treatment
Ovarian cancer is a prominent cancer worldwide with a relatively low survival rate for women diagnosed. Many individuals a...
Regulation of the P53 tumor suppressor gene and the Mcl-2 oncogene expression by an active herbal component delivered through a smart thermo-pH-sensitive PLGA carrier to improve Osteosarcoma treatment
Regulation of the P53 tumor suppressor gene and the Mcl-2 oncogene expression by an active herbal component delivered through a smart thermo-pH-sensitive PLGA carrier to improve Osteosarcoma treatment
Osteosarcoma (OS), a lethal malignancy, has witnessed an escalating incidence rate. Contemporary therapeutic strategies fo...
A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis
A therapeutical insight into the correlation between circRNAs and signaling pathways involved in cancer pathogenesis
Pre-messenger RNA molecules are back-spliced to create circular RNAs, which are non-coding RNA molecules. After a thorough...
The combined anti-tumor effects of 5-fluorouracil and neurokinin receptor inhibitor, aprepitant, against colorectal cancer: In vitro and in vivo study
The combined anti-tumor effects of 5-fluorouracil and neurokinin receptor inhibitor, aprepitant, against colorectal cancer: In vitro and in vivo study
Colorectal cancer (CRC) is one of the world’s largest health concerns with growing global incidence and mortality. T...
Selective targeting or reprogramming of intra-tumoral Tregs
Selective targeting or reprogramming of intra-tumoral Tregs
Regulatory T cells (Tregs) are critical immunosuppressive cells that are frequently present in the tumor microenvironment ...
CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
Inflammation disrupts bone metabolism and leads to bone damage. C-reactive protein (CRP) is a typical inflammation marker....
Advancements in biosensors for cancer detection: revolutionizing diagnostics
Advancements in biosensors for cancer detection: revolutionizing diagnostics
Cancer stands as the reigning champion of life-threatening diseases, casting a shadow with the highest global mortality ra...
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Urothelial Carcinoma of Bladder is complex disease with high mortality and recurrence rates. Current standard regimes have...
Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity
Lenvatinib is a multitargeted tyrosine kinase inhibitor capable of promoting apoptosis, suppressing angiogenesis, inhibiti...
Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia
Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia
Relapsed or refractory acute myeloid leukemia (AML) is associated with poor outcomes and resistance to therapy. The additi...
TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma
TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma
Tripartite motif–containing 29 (TRIM29), also known as the ataxia telangiectasia group D-complementing (ATDC) gene, ...
Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells
Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells
Breast cancer progression, metastasis and recurrence are largely driven by breast cancer stem cells (BCSCs), which constit...
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Jaber OI, Kirby PA. Alveolar soft part sarcoma. Arch Pathol Lab Med. 2015;139:1459–62.Article  CAS  PubMed  ...
Exploring the Potential of Essential Oil from Plectranthus amboinicus Leaves against Breast Cancer: In vitro and In silico Analysis
Exploring the Potential of Essential Oil from Plectranthus amboinicus Leaves against Breast Cancer: In vitro and In silico Analysis
Plectranthus amboinicus leaves were subjected to hydrodistillation to obtain essential oil (EO). Phytochemical analysis us...
An effective treatment approach of liposomally encapsulated metformin in colon cancer
An effective treatment approach of liposomally encapsulated metformin in colon cancer
Metformin is a drug that is widely used in the treatment of type-2 diabetes and its anticarcinogenic effect has been detec...
Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway
Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway
Prostate cancer is one of the most common cancers in men. Given the diverse nature of prostate cancer and its tendency to ...
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
In developing new cancer medications, attention has been focused on novel epigenetic medicines called histone deacetylase ...
Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for various cancers for decades. ...
Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment
Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment
Immunotherapies using immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T-cell therapy have achieved...
Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion
Upregulation of CELSR1 expression promotes ovarian cancer cell proliferation, migration, and invasion
Cadherin epidermal growth factor and laminin-G seven-pass G-type receptor 1 (CELSR1) is a planar cell polarity protein inv...
Enhanced therapeutic efficacy of doxorubicin/cyclophosphamide in combination with pitavastatin or simvastatin against breast cancer cells
Enhanced therapeutic efficacy of doxorubicin/cyclophosphamide in combination with pitavastatin or simvastatin against breast cancer cells
Fighting breast tumors mandates finding different agents devoid of chemotherapy side effects. Repurposing existing drugs, ...
Emerging treatment approaches for triple-negative breast cancer
Emerging treatment approaches for triple-negative breast cancer
Approximately, 15% of global breast cancer cases are diagnosed as triple-negative breast cancer (TNBC), identified as the ...
n-3 PUFAs synergistically enhance the efficacy of doxorubicin by inhibiting the proliferation and invasion of breast cancer cells
n-3 PUFAs synergistically enhance the efficacy of doxorubicin by inhibiting the proliferation and invasion of breast cancer cells
Breast cancer stands as a prominent contributor to cancer-related fatalities among women globally, characterized by an unf...
Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3
Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3
We previously reported that chitosan nanoparticle-encapsulated Naringenin (CS-NPs/NAR) could scavenge free radicals at low...
Comprehensive genomic profiling for oncological advancements by precision medicine
Comprehensive genomic profiling for oncological advancements by precision medicine
Considerable advancements in next generation sequencing (NGS) techniques have sparked the use of comprehensive genomic pro...
Examining the effect of activated cytotoxic (CD8+) T-cell exosomes to the lung cancer
Examining the effect of activated cytotoxic (CD8+) T-cell exosomes to the lung cancer
Lung cancer continues to be a major health problem worldwide owing to its incidence, and causes physical, psychological, s...
Efficacy and safety of Huachansu combined with adjuvant chemotherapy in resected colorectal cancer patients: a prospective, open-label, randomized phase II study
Efficacy and safety of Huachansu combined with adjuvant chemotherapy in resected colorectal cancer patients: a prospective, open-label, randomized phase II study
Although some studies in China have suggested Huachansu (HCS) combined with chemotherapy is effective in the treatment of ...
Mechanism of anticancer effect of ETP-45658, a PI3K/AKT/mTOR pathway inhibitor on HT-29 Cells
Mechanism of anticancer effect of ETP-45658, a PI3K/AKT/mTOR pathway inhibitor on HT-29 Cells
The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers, including colon cancer, making i...
Cancer stemness kinase inhibitor amcasertib: a promising therapeutic agent in ovarian cancer stem and cancer cell models with different genetic profiles
Cancer stemness kinase inhibitor amcasertib: a promising therapeutic agent in ovarian cancer stem and cancer cell models with different genetic profiles
Ovarian cancer, often referred to as the ‘silent killer,’ is a significant contributor to mortality rates. Eme...
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