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Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis
Targeting cellular metabolism is becoming a critical approach for stopping cancer progression. Limited information is avai...
Effect of PRKD3 on cell cycle in gastric cancer progression and downstream regulatory networks
Effect of PRKD3 on cell cycle in gastric cancer progression and downstream regulatory networks
Protein kinase D3 (PRKD3), belonging to the protein kinase D family, significantly influences tumor development and progre...
Identification of Isovitexin as a novel CYP17A1 inhibitor through virtual screening and evaluation of its anti-cancer effects in MCF-7 breast cancer cells
Identification of Isovitexin as a novel CYP17A1 inhibitor through virtual screening and evaluation of its anti-cancer effects in MCF-7 breast cancer cells
Over 75% of breast cancers are hormone receptor positive and are associated with better prognosis after treatment, when co...
Vitamin D3 and its active form calcitriol suppress erythroleukemia through upregulation of CHAC1 and downregulation of NOTCH1
Vitamin D3 and its active form calcitriol suppress erythroleukemia through upregulation of CHAC1 and downregulation of NOTCH1
Vitamin D3 (VD3) and its active form calcitriol (Ca) exhibit anti-neoplastic activity against several types of cancer, alt...
Enhancing KRAS G12D inhibitor sensitivity in pancreatic cancer through SHP2/PI3K pathway
Enhancing KRAS G12D inhibitor sensitivity in pancreatic cancer through SHP2/PI3K pathway
Pancreatic cancer with the KRAS G12D mutation, found in 40% of cases, is challenging to treat. MRTX1133, a non-covalent KR...
Targeting TGF-β: a promising strategy for cancer therapy
Targeting TGF-β: a promising strategy for cancer therapy
Transforming growth factor β (TGF-β) has important role in regulating the cellular processes including cell grow...
Microenvironment-based immunotherapy in oral cancer: a comprehensive review
Microenvironment-based immunotherapy in oral cancer: a comprehensive review
Oral cancer, a prevalent form of head and neck malignancy, accounts for 4% of global cancer cases. The most common type, o...
Alternative use of droxidopa for treating cervical cancer: inhibiting transferase, cell cycle signalling, and transport proteins via multitarget docking, DFT, MD simulations, and binding free energy studies
Alternative use of droxidopa for treating cervical cancer: inhibiting transferase, cell cycle signalling, and transport proteins via multitarget docking, DFT, MD simulations, and binding free energy studies
Cervical cancer develops due to the uncontrolled growth of abnormal cells in the cervix, mainly triggered by a persistent ...
Noncoding RNA (ncRNA)-mediated regulation of TLRs: critical regulator of inflammation in tumor microenvironment
Noncoding RNA (ncRNA)-mediated regulation of TLRs: critical regulator of inflammation in tumor microenvironment
Toll-like receptors (TLRs) are central components of the innate immune system as they recognize molecular patterns associa...
Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells
Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells
Overexpression of Mcl-1 causes hepatocellular carcinoma resistance to Bcl-2 inhibitors, but there are currently no direct ...
Curcumin-gold nanoshell mediated near-infrared irradiation on human ovarian cancer cell: in vitro study
Curcumin-gold nanoshell mediated near-infrared irradiation on human ovarian cancer cell: in vitro study
Ovarian cancer is considered a predominant female reproductive malignancy and poses a significant threat due to its 80R...
Mesoporous polydopamine nanoparticles coated with metal-polyphenol networks for demethylation therapy of lung cancer
Mesoporous polydopamine nanoparticles coated with metal-polyphenol networks for demethylation therapy of lung cancer
The treatment of lung cancer with azacitidine (AZA) is urgently in need of a novel delivery material due to its limitation...
Warhead-bearing natural compounds for multi-pathway irreversible inhibition to overcome drug resistance in colorectal cancer
Warhead-bearing natural compounds for multi-pathway irreversible inhibition to overcome drug resistance in colorectal cancer
Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths globally, with approximately 930000 fata...
Targeting immune cells in tumor microenvironment in triple negative breast cancer therapy: future perspective to overcome doxorubicin resistance and toxicity
Targeting immune cells in tumor microenvironment in triple negative breast cancer therapy: future perspective to overcome doxorubicin resistance and toxicity
Triple negative breast cancer (TNBC) has high recurrence and low survival rates among breast cancer types. So far, TNBC tr...
Curcumin suppresses malignant behaviors of ovarian cancer through regulation of tumor-associated macrophages
Curcumin suppresses malignant behaviors of ovarian cancer through regulation of tumor-associated macrophages
Curcumin, a natural polyphenol with established anti-tumor properties, has shown therapeutic potential in ovarian cancer. ...
Therapeutic potential of microbiome modulation in reproductive cancers
Therapeutic potential of microbiome modulation in reproductive cancers
The human microbiome, a complex ecosystem of microbial communities, plays a crucial role in physiological processes, and e...
Genetic analysis of HPV-16 L1 gene mutations and computational screening of therapeutic inhibitors for cervical cancer treatment
Genetic analysis of HPV-16 L1 gene mutations and computational screening of therapeutic inhibitors for cervical cancer treatment
Cervical cancer, the fourth most common carcinoma in women worldwide, is predominantly caused by persistent infection with...
YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1
YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1
Hepatocellular carcinoma (HCC) ranks as the sixth most prevalent cancer worldwide. The epithelial-mesenchymal transition (...
The role of kinesin superfamily proteins in hepatocellular carcinoma
The role of kinesin superfamily proteins in hepatocellular carcinoma
The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challeng...
Glycolytic pathway analysis and gene expression profiles of combination of aloe vera and paclitaxel on non-small cell lung cancer and breast cancer
Glycolytic pathway analysis and gene expression profiles of combination of aloe vera and paclitaxel on non-small cell lung cancer and breast cancer
The purpose of this study is to enhance the effectiveness of known anticancer medications using natural compounds. The stu...
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells
Cervical cancer, CC, is one of the malignant cancers in women worldwide. Many studies about the genesis and progression of...
Modulation of the tumor microenvironment in non-muscle-invasive bladder cancer by OncoTherad® (MRB-CFI-1) nanoimmunotherapy: effects on tumor-associated macrophages, tumor-infiltrating lymphocytes, and monoamine oxidases
Modulation of the tumor microenvironment in non-muscle-invasive bladder cancer by OncoTherad® (MRB-CFI-1) nanoimmunotherapy: effects on tumor-associated macrophages, tumor-infiltrating lymphocytes, and monoamine oxidases
Non-muscle-invasive bladder cancer (NMIBC) presents management challenges due to its high recurrence rate and a complex tu...
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Pheochromocytomas and paragangliomas (PCCs/PGLs) are uncommon neuroendocrine tumors with a significant genetic tendency. A...
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Risk management and self-management strategies for breast cancer-related lymphedema (BCRL) must balance best-evidence guid...
Essential components of the maintenance phase of complex decongestive therapy
Essential components of the maintenance phase of complex decongestive therapy
Complex decongestive therapy is the current gold standard for non-surgical clinical lymphedema management and consists of ...
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The identification of effective therapeutic modalities to manage lymphedema secondary to cancer is a high priority among p...
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
The cGAS-STING signaling pathway is indeed a pivotal component of the immune system and serve as a crucial link between in...
Salvianolic acid B inhibits the growth and metastasis of A549 lung cancer cells through the NDRG2/PTEN pathway by inducing oxidative stress
Salvianolic acid B inhibits the growth and metastasis of A549 lung cancer cells through the NDRG2/PTEN pathway by inducing oxidative stress
Salvianolic acid B (Sal B) has demonstrated anticancer activity against various types of cancer. However, the underlying m...
Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy
Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy
Transcripts longer than 200 nucleotides that are not translated into proteins are known as long non-coding RNAs, or lncRNA...
Multifaceted role of erlotinib in various cancer: nanotechnology intervention, patent landscape, and advancements in clinical trials
Multifaceted role of erlotinib in various cancer: nanotechnology intervention, patent landscape, and advancements in clinical trials
Erlotinib (ELB) is a tyrosine kinase inhibitor that targets the activity of Epidermal Growth Factor Receptor (EGFR) protei...
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