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Secretory autophagy mediates lysosomal and autophagic degradation for α-synuclein proteostasis
Author links open overlay panel, , AbstractAutophagy has two distinct pathways, degradation and secretion. Autophagic degr...
Improvement of the potency of a N1-methylpseudouridine-modified self-amplifying RNA through mutations in the RNA-dependent-RNA-polymerase
Author links open overlay panel, , , , , , , , ABSTRACTmRNA technology has widely incorporated modified nucleotides to tem...
Functional analysis of amino acid substitutions within human AGT1 in a cell-based platform to support the diagnosis of primary hyperoxaluria type 1
Primary hyperoxaluria type 1 (PH1) is caused by the functional deficit of alanine:glyoxylate aminotransferase (AGT1), resu...
Two stages of substrate discrimination dictate selectivity in the E. coli MetNI-Q ABC transporter system
Author links open overlay panel, , , , AbstractThe Escherichia coli MetNI-Q importer, an ATP-binding cassette (ABC) transp...
Dimerization of Cdc13 is essential for dynamic DNA exchange on telomeric DNA
Author links open overlay panel, , , ABSTRACTEukaryotic single-stranded DNA (ssDNA) binding proteins (ssBPs) protect telom...
O-GlcNAcylation of Fatty Acid Synthase is required for its proper subcellular localization, expression level and activity
Author links open overlay panel, , , , , , , , , , , AbstractFatty Acid Synthase (FASN) is involved in various fundamental...
Conformations of the three gates in S. cerevisiae topoisomerase II and their response to DNA, nucleotide and etoposide
Eukaryotic topoisomerase II (Topo II) catalyzes DNA relaxation and decatenation in an ATP-dependent reaction. Topo II is a...
Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication
Author links open overlay panel, , , , , , , AbstractHerpes Simplex Virus replicates by forming DNA concatemers using a si...
Cu/Zn-superoxide dismutase naturally fused with a β-propeller lactonase in Deinococcus radiodurans
Author links open overlay panel, , , , , , ABSTRACTCu/Zn-superoxide dismutase (Cu/Zn-SOD) is an antioxidant enzyme widely ...
A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110401Author links open overlay panel, , , α- and β-tubul...
Aberrant activation of IL-6/JAK/STAT3/FOSL1 signaling induces renal abnormalities in a Xenopus model of Joubert syndrome-related disorders
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110413Author links open overlay panel, , , , , , , , , , ...
Cathepsin K as a key regulator of myocardial fibrosis in dilated cardiomyopathy and a promising therapeutic target
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110421Author links open overlay panel, , , , , , , , , , ...
Understanding the substrate recognition and catalytic mechanism of 2-O-methyl fucosidases from glycoside hydrolase family 139
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110407Author links open overlay panel, , , , , , , , , , ...
Maintenance of proper phosphatidylinositol-4-phosphate level by Stt4 and Sac1 contributes to vesicular transport to and from the plasma membrane
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110410Author links open overlay panel, , , , , , Growing ...
Molecular basis for Gβγ-SNARE-mediated inhibition of synaptic vesicle fusion
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110377Author links open overlay panel, , , , , , , , , , ...
TFAP2C drives cisplatin resistance in bladder cancer by upregulating YAP and activating β-catenin signaling
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110387Author links open overlay panel, , , , , Cisplatin-...
The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110412Author links open overlay panel, , , Star-PAP is a ...
First-in-class inhibitors of Nsp15 endoribonuclease of SARS-CoV-2: Modeling, synthesis, and enzymatic assay of thiazolidinedione and rhodanine analogs
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110409Author links open overlay panel, , , , , , , , Duri...
An anti-CD47 antibody binds to a distinct epitope in a novel metal ion-dependent manner to minimize cross-linking of red blood cells
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110420Author links open overlay panel, , , , , , , , , , ...
Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer
Journal of Biological ChemistryVolume 301, Issue 8, August 2025, 110414Author links open overlay panel, , , , , , , , , , ...
The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils
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The NEDD4-binding protein N4BP1 degrades mRNA substrates through the coding sequence independent of nonsense-mediated decay
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Duality in disease: How two amino acid substitutions at actin residue 312 result in opposing forms of cardiomyopathy
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Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration
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RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition in vitro
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Structural profiles of the full phagocyte NADPH oxidase unveiled by combining computational biology and experimental knowledge
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Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors
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Bidirectional transfer of a small membrane-impermeable molecule between the Caenorhabditis elegans intestine and germline
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Structure–function analysis of tRNA t6A-catalysis, assembly, and thermostability of Aquifex aeolicus TsaD2B2 tetramer in complex with TsaE
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Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii
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