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The molecular principles underlying diverse functions of the SLC26 family of proteins
The molecular principles underlying diverse functions of the SLC26 family of proteins
Author links open overlay panel, AbstractMammalian SLC26 proteins are membrane-based anion transporters that belong to the...
The sensor of the bacterial histidine kinase CpxA is a novel dimer of extracytoplasmic Per-ARNT-Sim (PAS) domains
The sensor of the bacterial histidine kinase CpxA is a novel dimer of extracytoplasmic Per-ARNT-Sim (PAS) domains
Timothy H. S. Cho: Conceptualization, Investigation, Visualization, Methodology, Writing – Original Draft Cameron Murray: ...
Biochemical characterization of E. coli DnaC variants that alter DnaB helicase loading onto DNA
Biochemical characterization of E. coli DnaC variants that alter DnaB helicase loading onto DNA
Author links open overlay panel, AbstractDNA replication in E. coli starts with loading of the replicative helicase, DnaB,...
Immunometabolic crosstalk in Aedes fluviatilis Wolbachia pipientis symbiosis
Immunometabolic crosstalk in Aedes fluviatilis Wolbachia pipientis symbiosis
Author links open overlay panel, , , , , , , , , , ABSTRACTWolbachia pipientis is a maternally transmitted symbiotic bacte...
Functional identification of bacterial spermine, thermospermine, norspermine, norspermidine, spermidine, and N1-aminopropylagmatine synthases
Functional identification of bacterial spermine, thermospermine, norspermine, norspermidine, spermidine, and N1-aminopropylagmatine synthases
Spermine synthase is an aminopropyltransferase that adds an aminopropyl group to the essential polyamine spermidine to for...
The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
Author links open overlay panel, , , , , , , , , , , AbstractProtein phosphatase 2A (PP2A) is an essential serine/threonin...
Phospholamban inhibits the cardiac calcium pump by interrupting an allosteric activation pathway
Phospholamban inhibits the cardiac calcium pump by interrupting an allosteric activation pathway
allosteric regulationbiosensorcalcium ATPasecalcium transportcardiac musclefluorescence resonance energy transfer (FRET)mo...
Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria
Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria
KEYWORDSCoenzyme Q10 (CoQ10)UbiquinoneMitochondrial respiratory chain complexMitochondrial therapeuticsMembrane lipidBioen...
Pathogenic residue insertion in a neuronal nicotinic receptor alters intra- and inter-subunit interactions that tune channel gating
Pathogenic residue insertion in a neuronal nicotinic receptor alters intra- and inter-subunit interactions that tune channel gating
Research Article Collection: Molecular Bases of DiseasePathogenic residue insertion in a neuronal nicotinic receptor alter...
ARV1 deficiency induces lipid bilayer stress and enhances rDNA stability by activating the unfolded protein response in Saccharomyces cerevisiae
ARV1 deficiency induces lipid bilayer stress and enhances rDNA stability by activating the unfolded protein response in Saccharomyces cerevisiae
The stability of ribosomal DNA (rDNA) is maintained through transcriptional silencing by the NAD+-dependent histone deacet...
Ykt6 functionally overlaps with vacuolar and exocytic R-SNAREs in the yeast Saccharomyces cerevisiae
Ykt6 functionally overlaps with vacuolar and exocytic R-SNAREs in the yeast Saccharomyces cerevisiae
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex forms a 4-helix coiled-coil bund...
Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases
Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases
Keywordseosinophilancestral RNaseancestral sequence reconstructionRNase 2RNase 3eosinophil-derived neurotoxineosinophil ca...
Impaired malin expression and interaction with partner proteins in Lafora disease
Impaired malin expression and interaction with partner proteins in Lafora disease
Author links open overlay panel, , , , , , ABSTRACTLafora disease (LD) is an autosomal recessive myoclonus epilepsy with o...
Mitotic spindle positioning protein (MISP) preferentially binds to aged F-actin
Mitotic spindle positioning protein (MISP) preferentially binds to aged F-actin
Author links open overlay panel, , ABSTRACTActin bundling proteins crosslink filaments into polarized structures that shap...
Spatial organization of bacterial sphingolipid synthesis enzymes
Spatial organization of bacterial sphingolipid synthesis enzymes
Author links open overlay panel, , AbstractSphingolipids are produced by nearly all eukaryotes where they play significant...
TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells
TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells
Author links open overlay panel, , , , , , , , , AbstractHigher demand for nutrients including glucose is characteristic o...
A novel system to determine activity of individual uridine 5'-diphospho-glucuronosyltransferase (UGT) isoforms: recombinant UGT-beads
A novel system to determine activity of individual uridine 5'-diphospho-glucuronosyltransferase (UGT) isoforms: recombinant UGT-beads
Key Wordshuman glucuronosyltransferaserecombinant UGTenzyme kineticsmagnetizable beadsrUGT-beadsBSAfatty acidsimmobilizati...
Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae
Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae
Author links open overlay panel, , , , , , , , AbstractThe major human pathogen Streptococcus pneumoniae encounters the im...
Utility of protein-protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display
Utility of protein-protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display
Over the past three decades a diverse collection of small protein domains have been used as scaffolds to generate general-...
A proteomics-based survey reveals thrombospondin-4 as a ligand regulated by the mannose receptor in the injured lung
A proteomics-based survey reveals thrombospondin-4 as a ligand regulated by the mannose receptor in the injured lung
KeywordsEndocytosismacrophagemass spectrometry (MS)protein turnoverproteomicsurokinase plasminogen activator-associated pr...
Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells
Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells
Author links open overlay panel, , , , , , , , , , , AbstractSignificant advances have been made in reprogramming various ...
Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis
Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis
Author links open overlay panel, , , AbstractMethanogens are essential for the complete remineralization of organic matter...
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex
Author links open overlay panel, , , , , Abstract:The γ-secretase complexes are intramembrane cleaving proteases involved ...
Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
Key wordsMycobacteriumprotein structureredox homeostasis ErgothioneineErgothioneine-Biosynthesis C-S lyaseMsEgtENcEgt2The ...
Matrixed CDR-grafting: a neoclassical framework for antibody humanization and developability
Matrixed CDR-grafting: a neoclassical framework for antibody humanization and developability
Author links open overlay panel, , , , , , , , ABSTRACT:Discovery and optimization of a biotherapeutic monoclonal antibody...
Structure, dynamics and stability of the smallest and most complex 71 protein knot
Structure, dynamics and stability of the smallest and most complex 71 protein knot
Proteins can spontaneously tie a variety of intricate topological knots through twisting and threading of the polypeptide ...
Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores
Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores
Author links open overlay panel, , , ABSTRACTUropathogenic E. coli (UPEC) secrete multiple siderophore types to scavenge e...
Transcriptional Regulation of FACT Involves Coordination of Chromatin Accessibility and CTCF Binding
Transcriptional Regulation of FACT Involves Coordination of Chromatin Accessibility and CTCF Binding
Author links open overlay panel, , , , , , , , , , AbstractHistone chaperone FACT is well known to promote chromatin recov...
Structural characterization and functional insights into the Type II Secretion System of the poly-extremophile Deinococcus radiodurans
Structural characterization and functional insights into the Type II Secretion System of the poly-extremophile Deinococcus radiodurans
Author links open overlay panel, , , , , AbstractThe extremophile bacterium D. radiodurans boasts a distinctive cell envel...
Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs
Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs
KeywordsFIBCD1crystal structurebinding studieschitininnate immunityficolinshost-pathogen interactionstructural biologyThe ...
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