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Influence of cognitive and emotional factors on motor dual-task performance in nursing home residents. The mediating and moderating roles of cognition, concerns about falling, well-being, and depressive symptoms. A cross-sectional observational study
BackgroundThis study aimed (1) to compare walking performance under single (ST) and dual-task (DT) conditions with varying...
Associations between the oral microbiome, number of teeth and frailty among American adults: A cross-sectional study from NHANES 2009–2012
BackgroundThe intricate interrelationship between oral health, the number of teeth, oral microbiota, and frailty remains l...
Mechanistic insights into EIF6 as a target of Apigenin in alleviating chondrocyte senescence
PurposeApigenin, a flavonoid found in edible plants, has demonstrated therapeutic potential in various diseases, but its r...
Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis
Volume 203, May 2025, 112729Author links open overlay panel, , , , Highlights•Rheumatoid arthritis and sarcopenia share 25...
Age related gut microbiota regulates energy-related metabolism to influence natural aging phenotypes in the heart
Volume 203, May 2025, 112734Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Aging induced changes ...
Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques
As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related...
Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community
PurposeTo examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 com...
Age-related peculiarities of antibody-mediated humoral immune response following SARS-CoV-2 infection
Thousands of articles were published about the COVID-19 disease and hundreds about the immune response. But still little i...
Corrigendum to “Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition” [Exp. Gerontol. Volume 89 (2017), 45–56]
Volume 203, May 2025, 112733Author links open overlay panelJingxing Zhang a, Qiong Cai a, Ming Jiang c, Yigang Liu a, Hua ...
Sarcopenic obesity is associated with long-term trajectories of physical activity and sedentary behavior
Volume 204, 1 June 2025, 112752Author links open overlay panel, , Highlights•Sarcopenic obesity is associated with adverse...
Molecular mechanism of melatonin-mediated mitophagy regulating proline production to ameliorate skin aging
Collagen loss is one of the major contributor to signs of skin aging such as dryness, roughness, and wrinkle formation, wh...
Association of blood ethylene oxide levels with osteoarthritis and rheumatoid arthritis: Evidence from NHANES (2013–2020)
ObjectivesOsteoarthritis (OA) and rheumatoid arthritis (RA) are common conditions with important public health implication...
Balancing benefits and risks of aerobic exercise for aging and musculoskeletal health
BackgroundLong-term exercise is recognized as one of the most effective means of maintaining health after aging, but the r...
miRNA and piRNA differential expression profiles in Alzheimer's disease: A potential source of pathology and tool for diagnosis
Alzheimer's Disease (AD) is the most prevalent form of dementia and one of the leading causes of death in the United State...
Long-term prognostic value of CRP–albumin–lymphocyte index in elderly patients with heart failure with preserved ejection fraction
BackgroundHeart failure with preserved ejection fraction (HFpEF) is a complex and heterogeneous clinical condition charact...
Effects of Bufexamac, a class IIb HDAC inhibitor, on behavior and neuropathological features in an Aβ-induced rat model of Alzheimer's disease
It has been suggested that Alzheimer's disease (AD), a progressive neurological condition, can potentially be treated thro...
Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway
BackgroundIntervertebral disc degeneration (IVDD) represents a prevalent degenerative pathology of the spinal, primarily p...
Age at menarche and risk of non-alcoholic fatty liver disease: Insights from the NHANES 2017–2020 and Mendelian randomization analyses
Volume 204, 1 June 2025, 112748Author links open overlay panel, , , , , , , , , Highlights•Age at menarche (AAM) is consid...
UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosis
Osteoporosis is a prevalent public health issue and the underlying mechanism is an imbalance in bone remodeling. Excessive...
Sarcopenia index based on serum creatinine and cystatin C is associated with all-cause mortality in patients aged 50 and over with hip fracture
BackgroundSarcopenia index (SI), calculated as serum creatinine/cystatin C × 100, has emerged as a potential marker for mu...
scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages
scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages
The increased incidence of inflammatory diseases, infectious diseases, autoimmune disorders, and tumors in elderly individ...
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents
As older age and having certain comorbidities can influence humoral responses to vaccination, we studied antibody response...
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats
Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from ou...
Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART
Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART
Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, res...
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
The characteristics of ulcerative colitis (UC) in the elderly are quite different from the young population. Mitochondrial...
Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging
Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging
There is currently no standardized protocol for the measurement of gait speed in older adults, particularly regarding the ...
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering gut microbiota can allev...
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The gut microbiome is recognized as a pivotal factor in the pathophysiology of sarcopenia—a condition marked by the ...
Utilisation and Outcome of Cranial CT Imaging in Older Adults Attending ED Following a Fall
Utilisation and Outcome of Cranial CT Imaging in Older Adults Attending ED Following a Fall
Healthcare demand from falls in older adults is increasing, but guidance from the literature is lacking on the value of ne...
Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent fr...
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