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Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities ...
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized ...
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly...
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated w...
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 ...
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Immunosenescence is the age-related changes in the immune system, namely, progressively higher levels of circulating infla...
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponenti...
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
To examine whether physical activity can mitigate the mortality risk associated with disability in activities of daily liv...
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
The aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation...
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging
The frailty index (FI) uses a deficit accumulation approach to derive a single, comprehensive, and replicable indicator of...
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease
First-degree relatives of Alzheimer’s disease patients constitute a key population in the search for early markers. ...
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senescent cell number increases with age in different tissues, leading to greater senescent cell load, proinflammatory str...
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Older adults with cognitive impairment (CI) are twice as likely to fall compared to the general older adult population. Tr...
Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults
Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults
Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of...
Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment
Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment
Many studies have shown that the prevalence of degenerative spinal cord compression increases with age. However, most case...
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis
Colitis, a subtype of inflammatory bowel disease (IBD), is a multifactorial disorder characterized by chronic inflammation...
Fear extinction is impaired in aged rats
Fear extinction is impaired in aged rats
Normal aging is accompanied by broad loss of cognitive function in humans and rodents, including declines in cognitive fle...
Cardiorespiratory fitness is associated with cognitive performance in 80 + -year-olds: Detangling processing levels
Cardiorespiratory fitness is associated with cognitive performance in 80 + -year-olds: Detangling processing levels
Cardiorespiratory fitness is known to protect against cognitive decline in older adults. Specifically, it has been shown t...
Frontal–temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults
Frontal–temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults
Aging is a major risk for cognitive decline and transition to dementia. One well-known age-related change involves decreas...
Physical Exercise on Physical and Cognitive Function in Institutionalized Older Adults with Dementia: A Systematic Review
Physical Exercise on Physical and Cognitive Function in Institutionalized Older Adults with Dementia: A Systematic Review
Dementia affects 50 million people worldwide and that number may treble by 2050, yet there are not many studies for this p...
Eldercaring Conflict Checklist (ECC): Development, Pilot, and Initial Validation of Scale
Eldercaring Conflict Checklist (ECC): Development, Pilot, and Initial Validation of Scale
Unresolved family conflicts regarding caring for older adults can devastate their overall health, well-being, and the qual...
Mediating Role of Self-Efficacy in the Relationship Between Social Support and Perceived Stress Among Caregivers of Older Patients Under Hemodialysis
Mediating Role of Self-Efficacy in the Relationship Between Social Support and Perceived Stress Among Caregivers of Older Patients Under Hemodialysis
The study aimed to explore the relationship between social support and perceived stress, considering self-efficacy as a me...
Positive Impact of an Educational Brochure on Follow-up for a Formal Hearing Evaluation
Positive Impact of an Educational Brochure on Follow-up for a Formal Hearing Evaluation
AbstractBackground and Objectives. Half of older persons experience serious hearing loss, yet it remains under-assessed in...
The effects of the built environment on the mental health of older adults: A case study in Hangzhou, China
The effects of the built environment on the mental health of older adults: A case study in Hangzhou, China
AbstractBackground and Objectives. This study examines the association between the built environment and mental health amo...
Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
Genotoxic and cytotoxic drugs, widely used in anticancer therapy, target proliferating cells and induce cell death through...
Association between Telomere Length and Geriatric Status in Centenarians
Association between Telomere Length and Geriatric Status in Centenarians
Aim: To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. M...
Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts
Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts
Background: The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity and act...
Senolytic Drugs: Implications for Clinical Practice
Senolytic Drugs: Implications for Clinical Practice
Studying the mechanisms of aging is one of the most important goals of modern science. A significant amount of data on the...
Brain Aging
Brain Aging
Brain aging is part of the aging of the whole body, largely determining the success of general aging and the quality of li...
Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease
Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease
In spite of numerous studies, pathogenesis of the sporadic (not inherited) form of Alzheimer’s disease (AD) still re...
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