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Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice
Research ArticleTransplantation Open Access | 10.1172/JCI177460 Nana Talvard-Balland,1,2 ...
Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses
TCR activation induces VEGF-B expression and secretion in T cells. To assess the autocrine metabolic regulators for T cel...
LOXL2-induced PEAR1 Ser891 phosphorylation suppresses CD44 degradation and promotes triple-negative breast cancer metastasis
Sex as a biological variable. This study exclusively examined female human breast tissue microarrays and female mice, bec...
Decoding the decline: unveiling drivers of sarcopenia
Conserved across a majority of mammalian species, sarcopenia is the age-related loss of skeletal muscle mass and function...
Human genetics and epigenetics of alcohol use disorder
While the field of AUD genetics has made considerable progress, substantial gaps persist (similar to other psychiatric di...
Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics
Research ArticleAgingMuscle biology Open Access | 10.1172/JCI172890 Haiming L. Kerr,1,2 K...
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication
Research ArticleEndocrinology Open Access | 10.1172/JCI178303 Hui Wang,1 Shanshan Guo,1 ...
CDKL3 is a targetable regulator of cell cycle progression in cancers
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI178428 Haijiao Zhang,1 ...
Peripheral gating of mechanosensation by glial diazepam binding inhibitor
Research ArticleNeuroscience Open Access | 10.1172/JCI176227 Xinmeng Li,1 Arthur Silveira...
It’s good to know what to BACE the specificity of your inhibitors on
A recent breakthrough in the treatment of the initial stages of Alzheimer’s disease (AD) is marked by the first approved ...
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice
Research ArticleEndocrinology Open Access | 10.1172/JCI176136 Charanya Muralidharan,1 Fei...
The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling
Research ArticleAging Open Access | 10.1172/JCI170550 Andree Schmidt,1,2,3,4 Brian Hrupka...
MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction
Research ArticlePulmonologyTransplantation Open Access | 10.1172/JCI168393 Natalie M. Walker,...
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
Original citation: J Clin Invest. 2024;134(10):e173278. https://doi.org/10.1172/JCI173278 Citation for this corrigendum: ...
Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease
Research ArticleGastroenterologyInflammation Open Access | 10.1172/JCI173835 Bo-Jun Ke,1 ...
Potentiation of BKCa channels by cystic fibrosis transmembrane conductance regulator correctors VX-445 and VX-121
In the human airway, activation of basolateral KCa3.1 promotes transepithelial Cl– secretion across WT and corrected F508...
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Neutrophils decrease Ca2+-associated proteins and cellular proliferation in hepatocytes without cellular damage. To mimic...
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
Research ArticleInflammationNeuroscience Open Access | 10.1172/JCI177692 Marcel S. Woo,1 ...
SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm
Research ArticleVascular biology Open Access | 10.1172/JCI173690 Tianyu Song,1,2 Shuang Z...
SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm
SLC44A2, also known as CTL2 (choline transporter–like protein 2), is a gene located on chromosome 19p13.2 with 24 exons. ...
Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1
Research ArticleHepatologyVirology Open Access | 10.1172/JCI171533 Ming Zeng,1 Zizhi Tang,1...
Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis
Research ArticleDermatologyImmunology Open Access | 10.1172/JCI171088 Satoshi Nakamizo,1,2 ...
Bone-derived PDGF-BB drives brain vascular calcification in male mice
Aged mice develop brain calcification primarily in the thalamus region. Brain calcification is commonly detected in elder...
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity
Research ArticleDevelopmentReproductive biology Open Access | 10.1172/JCI161701 Adriana Lofrano...
Does activating brown fat contribute to important metabolic benefits in humans? Yes!
Research on mouse FA metabolism has shown how triglyceride-rich lipoproteins (TRL) are taken up through a sequence of tis...
High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance
Research LetterCOVID-19Infectious disease Open Access | 10.1172/JCI173715 Fang Yun Lim,1,2 ...
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T
Research ArticleMetabolismTherapeutics Open Access | 10.1172/JCI163464 Kentaro Ito,1,2 Go T...
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Research ArticleVaccines Open Access | 10.1172/JCI166827 Atsushi Kawai,1,2 Nagisa Tokunoh,2...
Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters
Clinical MedicineAutoimmunityDermatology Open Access | 10.1172/JCI166357 Dawoon Han,1 A Yeo...
The gift of preexisting immunity for developing an alternative vaccine strategy
The SARS-CoV-2 pandemic brought an immense advancement in vaccine development, resulting in the worldwide distribution of...
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