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Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1
Research ArticleHepatologyVirology Open Access | 10.1172/JCI171533 Ming Zeng,1 Zizhi Tang,1...
Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis
Research ArticleDermatologyImmunology Open Access | 10.1172/JCI171088 Satoshi Nakamizo,1,2 ...
Bone-derived PDGF-BB drives brain vascular calcification in male mice
Aged mice develop brain calcification primarily in the thalamus region. Brain calcification is commonly detected in elder...
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity
Research ArticleDevelopmentReproductive biology Open Access | 10.1172/JCI161701 Adriana Lofrano...
Does activating brown fat contribute to important metabolic benefits in humans? Yes!
Research on mouse FA metabolism has shown how triglyceride-rich lipoproteins (TRL) are taken up through a sequence of tis...
High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance
Research LetterCOVID-19Infectious disease Open Access | 10.1172/JCI173715 Fang Yun Lim,1,2 ...
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T
Research ArticleMetabolismTherapeutics Open Access | 10.1172/JCI163464 Kentaro Ito,1,2 Go T...
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Research ArticleVaccines Open Access | 10.1172/JCI166827 Atsushi Kawai,1,2 Nagisa Tokunoh,2...
Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters
Clinical MedicineAutoimmunityDermatology Open Access | 10.1172/JCI166357 Dawoon Han,1 A Yeo...
The gift of preexisting immunity for developing an alternative vaccine strategy
The SARS-CoV-2 pandemic brought an immense advancement in vaccine development, resulting in the worldwide distribution of...
Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets
Research ArticleCell biologyOncology Open Access | 10.1172/JCI168146 Ricardo Cruz-Acuña,1 S...
Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen
Research ArticleMetabolismVascular biology Open Access | 10.1172/JCI172600 Ye Yang,1,2 Anne...
Recruitment of naive CD4+ T cells by the recombinant zoster vaccine correlates with persistent immunity
Research ArticleVaccines Open Access | 10.1172/JCI172634 Kerry J. Laing,1 Emily S. Ford,1,2...
Advances in understanding the mechanism of action of adult vaccines
Since the development of vaccines for herpes zoster (HZ), there has been increasing recognition of its importance, especi...
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Research ArticleCell biologyOncology Open Access | 10.1172/JCI168277 Callum Beach,1 David M...
Human brown adipose tissue is not enough to combat cardiometabolic diseases
A multi-organ response drives the large increase in whole body energy expenditure during experimental cold-exposure condi...
Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis
To study the role of endothelial ADAM10 in S. aureus sepsis, we generated transgenic mice that enable endothelial cell–sp...
Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing
Research ArticleGastroenterology Open Access | 10.1172/JCI170771 Rizwan Ahmad,1 Balawant Ku...
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1–positive regulator for tumor immune evasion
Identification of ATXN3 as a PD-L1–positive regulator through unbiased CRISPR screening. To identify the specific deubiqu...
USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis
Research ArticleAutoimmunityImmunology Open Access | 10.1172/JCI169365 Aiting Wang,1,2,3 Ha...
Human brown fat and metabolic disease: a heated debate
In parallel to the studies of rodent thermogenic adipose tissue, efforts to understand the importance of BAT in humans ha...
Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract
1Department of Microbiology and Immunology,2Department of Pathology, and3Department of Pediatrics, University of Iowa, ...
Intracytoplasmic sperm injection induces transgenerational abnormalities in mice
Research ArticleReproductive biologyStem cells Open Access | 10.1172/JCI170140 Mito Kanatsu-Shi...
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models
Research ArticleCell biologyTherapeutics Open Access | 10.1172/JCI162148 Supreet Agarwal,1 ...
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression
Research ArticleImmunologyOncology Open Access | 10.1172/JCI163802 Zhihong Chen,1,2,3 Bruno...
FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters
Research ArticleOncologyStem cells Open Access | 10.1172/JCI166666 Mengjiao Li,1 Tatsunori ...
Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies
Research ArticleHematologyOncology Open Access | 10.1172/JCI170169 Stephen Jun Fei Chong,1 ...
Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
Clinical MedicineEndocrinologyMetabolism Open Access | 10.1172/JCI173495 Andrew A. Welch,1 ...
Recent advances in lung organoid development and applications in disease modeling
Lung organoids derived from AdSCs are attractive models for investigating epithelial stem cell potential and cellular int...
A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models
Research ArticleNeuroscienceTherapeutics Open Access | 10.1172/JCI164792 Susumu Ikenoshita,1,2 ...
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