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Structure, function and evolution of the HerA subfamily proteins
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Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals
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miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9
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DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines
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Exploring the removal of Spo11 and topoisomerases from DNA breaks in S. cerevisiae by human Tyrosyl DNA Phosphodiesterase 2
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DNA synthesis across DNA hairpins by human PrimPol
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The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity
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Induction of homologous recombination by site-specific replication stress
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Tolerating DNA damage by repriming: Gap filling in the spotlight
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Stressed? Break-induced replication comes to the rescue!
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From the TOP: Formation, recognition and resolution of topoisomerase DNA protein crosslinks
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Transcription reprogramming and endogenous DNA damage
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From rest to repair: Safeguarding genomic integrity in quiescent cells
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C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks
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An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
Cellular metabolism contributes to the production of reactive nitrogen intermediates (RNI), and reactive oxygen species (R...
What are the DNA lesions underlying formaldehyde toxicity?
What are the DNA lesions underlying formaldehyde toxicity?
The simplest and most reactive naturally occurring aldehyde is formaldehyde (CH2O). It has been known since the 1940’s tha...
DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
Volume 138, June 2024, 103677Author links open overlay panelJing Ge a, Le P. Ngo a, Simran Kaushal a, Ian J. Tay a, Elina ...
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
The polymerase δ (Polδ) is a critical enzyme responsible for synthesizing nascent DNA strands in the eukaryotic genome [1]...
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
Radiotherapy is one of the key treatment modalities for cancer, responsible for ∼ 50% of cancer cures. DNA damage response...
Genomic stress and impaired DNA repair in Alzheimer disease
Genomic stress and impaired DNA repair in Alzheimer disease
Alzheimer disease (AD) was first described in 1906 by German psychiatrist and neuroanatomist Dr. Alois Alzheimer [1]. In t...
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to ...
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97 (also known as VCP), are essential fo...
The role of rRNA in maintaining genome stability
The role of rRNA in maintaining genome stability
Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled n...
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an att...
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
DNA is considered a major target for ionizing radiation (IR)-based therapies [1], [2], [3]. Exposure of cells to IR has lo...
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP (cGAMP) synthase (cGAS) - stimulator of in...
Somatic Mutation Patterns at Ig and Non-Ig Loci
Somatic Mutation Patterns at Ig and Non-Ig Loci
AbbreviationsAadenosine (in RNA) and deoxyadenosine (in DNA)A>>Tmutations in DNA at A exceed mutations at TA-to-Iade...
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
SWI/SNF complexes are a conserved eukaryotic family of chromatin remodelling activities. In mammalian cells, this family c...
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (Fig. 1 A), is an approved...
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