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An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities
Cellular metabolism contributes to the production of reactive nitrogen intermediates (RNI), and reactive oxygen species (R...
What are the DNA lesions underlying formaldehyde toxicity?
What are the DNA lesions underlying formaldehyde toxicity?
The simplest and most reactive naturally occurring aldehyde is formaldehyde (CH2O). It has been known since the 1940’s tha...
DNA repair deficiencies and neurodegeneration
DNA repair deficiencies and neurodegeneration
Neurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer’s Disease i...
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176–103202]
Volume 138, June 2024, 103677Author links open overlay panelJing Ge a, Le P. Ngo a, Simran Kaushal a, Ian J. Tay a, Elina ...
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates
The polymerase δ (Polδ) is a critical enzyme responsible for synthesizing nascent DNA strands in the eukaryotic genome [1]...
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors
Radiotherapy is one of the key treatment modalities for cancer, responsible for ∼ 50% of cancer cures. DNA damage response...
Genomic stress and impaired DNA repair in Alzheimer disease
Genomic stress and impaired DNA repair in Alzheimer disease
Alzheimer disease (AD) was first described in 1906 by German psychiatrist and neuroanatomist Dr. Alois Alzheimer [1]. In t...
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to ...
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks
The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97 (also known as VCP), are essential fo...
The role of rRNA in maintaining genome stability
The role of rRNA in maintaining genome stability
Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled n...
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an att...
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
DNA is considered a major target for ionizing radiation (IR)-based therapies [1], [2], [3]. Exposure of cells to IR has lo...
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP (cGAMP) synthase (cGAS) - stimulator of in...
Somatic Mutation Patterns at Ig and Non-Ig Loci
Somatic Mutation Patterns at Ig and Non-Ig Loci
AbbreviationsAadenosine (in RNA) and deoxyadenosine (in DNA)A>>Tmutations in DNA at A exceed mutations at TA-to-Iade...
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
SWI/SNF complexes are a conserved eukaryotic family of chromatin remodelling activities. In mammalian cells, this family c...
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (Fig. 1 A), is an approved...
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
Anna V. Yudkina: Methodology, Formal analysis, Investigation, Resources, Data Curation, Writing - Original Draft, Visualiz...
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
Genomic integrity is critical to maintain the normal function of organisms. Pathological DNA double strand breaks (DSBs) h...
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
Renal cell carcinoma (RCC) is a malignancy in the urinary system originating from the renal tubular epithelium with a high...
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
ADP-ribosyl transferase Diptheria toxin-like 1 (ARTD1), also known as Poly(ADP-ribose) polymerase 1 (PARP1), is a 116 kDa,...
The entanglement of DNA damage and pattern recognition receptor signaling
The entanglement of DNA damage and pattern recognition receptor signaling
Cells are under constant pressure to suppress DNA damage originating from both exogenous and endogenous sources. Cellular ...
The impact of chromatin on double-strand break repair: Imaging tools and discoveries
The impact of chromatin on double-strand break repair: Imaging tools and discoveries
Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the DNA. Accurate repair of this...
DNA Repair Deficiency and the Immune Microenvironment: A Pathways Perspective
DNA Repair Deficiency and the Immune Microenvironment: A Pathways Perspective
Living organisms are constantly exposed to endogenous and exogenous agents that have the potential to damage cellular DNA....
Regulation of DNA damage-induced HLA class I presentation
Regulation of DNA damage-induced HLA class I presentation
Radiotherapy and DNA damage-based chemotherapy targeting tumor cells are potential partners of immune checkpoint inhibitor...
Telomeres as hotspots for innate immunity and inflammation
Telomeres as hotspots for innate immunity and inflammation
53BP1Tumor Protein P53 Binding Protein 1AGSAicardi-goutières syndromeALTAlternative lengthening of telomeresalt-EJAlternat...
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
Eukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory response...
UvrD-like Helicase Hmi1 Has an ATP Independent Role in Yeast Mitochondrial DNA Maintenance
UvrD-like Helicase Hmi1 Has an ATP Independent Role in Yeast Mitochondrial DNA Maintenance
ATP production via oxidative phosphorylation is arguably the most prominent function of mitochondria. In all eukaryotes, a...
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses
Cells possess an inherent and evolutionarily conserved ability to detect and respond to the presence of foreign and pathol...
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way
Alzheimer’s disease (AD) is defined neuropathologically by a progressively deposition of amyloid β (Aβ) in parenchyma and ...
Multi-scale cellular imaging of DNA double strand break repair
Multi-scale cellular imaging of DNA double strand break repair
AbbreviationsCNNconvolutional neural networkDNA-PAINTDNA-based Point Accumulation for Imaging in Nanoscale TopographyDSBDN...
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