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The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress t...
Bone marrow progenitor-like cells against leukemia cure
Bone marrow progenitor-like cells against leukemia cure
Relapse in T cell acute lymphoblastic leukemia (T-ALL) constitutes a challenge. A subclonal population of bone marrow prog...
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphobla...
Anti-metastatic extracellular vesicles carrying DNA
Anti-metastatic extracellular vesicles carrying DNA
Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. N...
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EV...
Using machine learning to translate tumor dependencies
Using machine learning to translate tumor dependencies
Cancer dependency maps have accelerated the discovery of essential genes and potential drug targets. Here we used machine ...
Predicting the risk of prostate cancer recurrence through the lens of evolution
Predicting the risk of prostate cancer recurrence through the lens of evolution
Current prostate cancer risk predictors are not able to fully capture a patient’s risk of recurrence at the time of ...
AI-assisted detection of lymph node metastases safely reduces costs and time
AI-assisted detection of lymph node metastases safely reduces costs and time
Our non-randomized single-center clinical trial demonstrates the safety, cost-saving and time-saving potential of artifici...
γδ T cells as critical anti-tumor immune effectors
γδ T cells as critical anti-tumor immune effectors
While the effector cells that mediate anti-tumor immunity have historically been attributed to αβ T cells and na...
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Combination approaches are needed to strengthen and extend the clinical response to KRASG12C inhibitors (KRASG12Ci). Here,...
Enhanced precision in immunotherapy
Enhanced precision in immunotherapy
Recent advancements in targeted immune checkpoint blockade (ICB) therapy have reshaped cancer treatment paradigms. However...
SOS1 inhibitor combinations overcome KRAS inhibitor resistance
SOS1 inhibitor combinations overcome KRAS inhibitor resistance
Combining SOS1 inhibitors with KRAS inhibitors improved the depth and durability of response in lung and colorectal cancer...
Author Correction: Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues
These authors contributed equally: Zijie Feng, Xin HeDepartment of Cancer Biology, Abramson Family Cancer Research Institu...
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these ce...
Author Correction: Breaking the performance ceiling for neoantigen immunogenicity prediction
Authors and AffiliationsAchilles Therapeutics Ltd, London, UKHugh O’Brien, Max Salm, Laura T. Morton, Felix O’Farrell, Pab...
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors
Tailoring optimal treatment for individual cancer patients remains a significant challenge. To address this issue, we deve...
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemoge...
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple my...
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of...
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
In this prospective, interventional phase 1 study for individuals with advanced sarcoma, we infused autologous HER2-specif...
First, novel and paradigm-shifting
First, novel and paradigm-shifting
In delineating scientific findings, authors should avoid assertions of primacy and novelty, in favor of measured descripti...
A deep dive into transmissible cancer evolution in bivalve mollusks
A deep dive into transmissible cancer evolution in bivalve mollusks
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and ...
Myeloma evades T cell-engaging therapies
Myeloma evades T cell-engaging therapies
Chimeric antigen receptor T cells and T cell-redirecting bispecific antibody therapies are changing the landscape of myelo...
Endothelium directs fat remodeling in cachexia
Endothelium directs fat remodeling in cachexia
Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cach...
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function...
Turning a failing PhD around
Turning a failing PhD around
Charles Swanton obtained a PhD from the Imperial Cancer Research Fund Laboratories (now the Francis Crick Institute) in 19...
Targeting network circuitry in glioma
Targeting network circuitry in glioma
The nervous system regulates cancer progression, and the importance of neuron–glioma communication in tumor growth i...
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