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Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) emerges from mutant KRAS-harboring but dormant low-grade pancreatic intraepithelia...
Will it be a turning point?
Will it be a turning point?
Sarah-Maria Fendt received her doctoral degree from ETH Zurich, Switzerland, and she conducted her postdoctoral research a...
Author Correction: Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory/relapsed large B cell lymphoma: a phase 1 trial
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Tumor-infiltrating lymphocyte therapies in gastrointestinal cancer
Immunotherapy that targets immune checkpoints such as PD-1 and PD-L1 has revolutionized treatment for several solid tumors...
Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international trial
Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international trial
Sentinel lymph node (SLN) biopsy with ultrastaging is standard in endometrial and vulvar cancers, whereas systematic pelvi...
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages
Resistance to cyclin-dependent kinase 4/6 (CDK4/CDK6) inhibitors leads to treatment failure and disease progression in wom...
An unexpected career in cancer metabolism
An unexpected career in cancer metabolism
Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Gene...
Highlights from the 2025 ASCO Annual Meeting
The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting convened a global community of oncology professionals...
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress t...
Bone marrow progenitor-like cells against leukemia cure
Bone marrow progenitor-like cells against leukemia cure
Relapse in T cell acute lymphoblastic leukemia (T-ALL) constitutes a challenge. A subclonal population of bone marrow prog...
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphobla...
Anti-metastatic extracellular vesicles carrying DNA
Anti-metastatic extracellular vesicles carrying DNA
Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. N...
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EV...
Using machine learning to translate tumor dependencies
Using machine learning to translate tumor dependencies
Cancer dependency maps have accelerated the discovery of essential genes and potential drug targets. Here we used machine ...
Predicting the risk of prostate cancer recurrence through the lens of evolution
Predicting the risk of prostate cancer recurrence through the lens of evolution
Current prostate cancer risk predictors are not able to fully capture a patient’s risk of recurrence at the time of ...
AI-assisted detection of lymph node metastases safely reduces costs and time
AI-assisted detection of lymph node metastases safely reduces costs and time
Our non-randomized single-center clinical trial demonstrates the safety, cost-saving and time-saving potential of artifici...
γδ T cells as critical anti-tumor immune effectors
γδ T cells as critical anti-tumor immune effectors
While the effector cells that mediate anti-tumor immunity have historically been attributed to αβ T cells and na...
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Combination approaches are needed to strengthen and extend the clinical response to KRASG12C inhibitors (KRASG12Ci). Here,...
Enhanced precision in immunotherapy
Enhanced precision in immunotherapy
Recent advancements in targeted immune checkpoint blockade (ICB) therapy have reshaped cancer treatment paradigms. However...
SOS1 inhibitor combinations overcome KRAS inhibitor resistance
SOS1 inhibitor combinations overcome KRAS inhibitor resistance
Combining SOS1 inhibitors with KRAS inhibitors improved the depth and durability of response in lung and colorectal cancer...
Author Correction: Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues
These authors contributed equally: Zijie Feng, Xin HeDepartment of Cancer Biology, Abramson Family Cancer Research Institu...
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these ce...
Author Correction: Breaking the performance ceiling for neoantigen immunogenicity prediction
Authors and AffiliationsAchilles Therapeutics Ltd, London, UKHugh O’Brien, Max Salm, Laura T. Morton, Felix O’Farrell, Pab...
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors
Tailoring optimal treatment for individual cancer patients remains a significant challenge. To address this issue, we deve...
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemoge...
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple my...
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of...
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