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Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis
Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. The aim of this study was to explore the ef...
BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/β-catenin pathway
BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/β-catenin pathway
The function of Biliverdin Reductase A (BLVRA) in hepatocellular carcinoma (HCC) cells proliferation, invasion and migrati...
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines
Acute myeloid leukemia (AML) is a form of blood cancer that arise as a result of clonal proliferation of malignant myeloid...
LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling
LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling
Acute myeloid leukemia (AML) is a hematologic disease associated with genetic abnormalities. This study aimed to explore t...
The lncRNA lnc-TSI antagonizes sorafenib resistance in hepatocellular carcinoma via downregulating miR-4726-5p expression and upregulating KCNMA1 expression
The lncRNA lnc-TSI antagonizes sorafenib resistance in hepatocellular carcinoma via downregulating miR-4726-5p expression and upregulating KCNMA1 expression
Acquired drug resistance is a main reason for limiting the application of sorafenib in HCC treatment. This study aimed to ...
Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis
Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis
The histone lysine demethylase 3 A (KDM3A) is vital for the regulation of cancer physiology and pathophysiology. ...
VNS improves VSMC metabolism and arteriogenesis in infarcted hearts through m/n-AChR-Akt-SDF-1α in adult male rats
VNS improves VSMC metabolism and arteriogenesis in infarcted hearts through m/n-AChR-Akt-SDF-1α in adult male rats
Vagal nerve stimulation (VNS) provides a novel therapeutic strategy for injured hearts by activating cholinergic anti-infl...
Orientin alleviates ox-LDL-induced oxidative stress, inflammation and apoptosis in human vascular endothelial cells by regulating Sestrin 1 (SESN1)-mediated autophagy
Orientin alleviates ox-LDL-induced oxidative stress, inflammation and apoptosis in human vascular endothelial cells by regulating Sestrin 1 (SESN1)-mediated autophagy
Endothelial cells are a crucial component of the vessel-tissue wall and exert an important role in atherosclerosis (AS). T...
Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap
Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap
Sepsis has a systemic inflammatory response syndrome caused by infection. While neutrophils play contradictory roles in di...
TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells
TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells
Differentiation of lens fiber cells involves a complex interplay of signals from growth factors together with tightly regu...
Overview of the compromised mucosal integrity in celiac disease
Overview of the compromised mucosal integrity in celiac disease
Intestinal epithelium is a dynamic cellular layer that lines the small-bowel and makes a relatively impenetrable barrier t...
Toll-like receptor 3 signaling drives enteric glial cells against dextran sulfate sodium-induced colitis in mice
Toll-like receptor 3 signaling drives enteric glial cells against dextran sulfate sodium-induced colitis in mice
The activation of toll-like receptor 3 (TLR3) has been reported to attenuate astrocytes injury in central nervous system, ...
Regulatory role of N-myc downregulated genes in amelogenesis in rats
Regulatory role of N-myc downregulated genes in amelogenesis in rats
Cytodifferentiation of odontogenic cells, a late stage event in odontogenesis is based on gene regulation. However, studie...
Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer
Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer
Quercetin has been documented to possess a multitude of pharmacological effects, encompassing antioxidant, antiviral, anti...
New insights into the treatment of polycystic ovary syndrome: HKDC1 promotes the growth of ovarian granulocyte cells by regulating mitochondrial function and glycolysis
New insights into the treatment of polycystic ovary syndrome: HKDC1 promotes the growth of ovarian granulocyte cells by regulating mitochondrial function and glycolysis
Polycystic ovary syndrome (PCOS) is an endocrine disease, and its pathogenesis and treatment are still unclear. Hexokinase...
LOC102549726/miR-760-3p network is involved in the progression of ISO-induced pathological cardiomyocyte hypertrophy via endoplasmic reticulum stress
LOC102549726/miR-760-3p network is involved in the progression of ISO-induced pathological cardiomyocyte hypertrophy via endoplasmic reticulum stress
Pathological cardiac hypertrophy (CH) is featured by myocyte enlargement and cardiac malfunction. Multiple signaling pathw...
Investigation of miR-26b and miR-27b expressions and the effect of quercetin on fibrosis in experimental pulmonary fibrosis
Investigation of miR-26b and miR-27b expressions and the effect of quercetin on fibrosis in experimental pulmonary fibrosis
In this study, investigation of the effects of Quercetin on Bleomycin-induced pulmonary fibrosis and fibrosis-associated m...
The circSNX14 functions as a tumor suppressor via the miR-562/ LATS2 pathway in hepatocellular carcinoma cells
The circSNX14 functions as a tumor suppressor via the miR-562/ LATS2 pathway in hepatocellular carcinoma cells
Circular RNAs (circRNAs) play critical roles in the initiation and progression of various cancers. However, the potential ...
Mitochondria as a target for exercise-mitigated type 2 diabetes
Mitochondria as a target for exercise-mitigated type 2 diabetes
Type 2 diabetes mellitus (T2DM) is one of most common metabolic diseases and continues to be a leading cause of death worl...
Effects of abnormal expression of CD73 on malignant phenotype of nasopharyngeal carcinoma
Effects of abnormal expression of CD73 on malignant phenotype of nasopharyngeal carcinoma
Cluster of differentiation (CD) 73, encoded by the NT5E gene, plays important enzymatic and non-enzymatic roles in cells. ...
Osteopontin: an essential regulatory protein in idiopathic pulmonary fibrosis
Osteopontin: an essential regulatory protein in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic lung disease characterized by abnormal proliferation and act...
Intra-articular delivery of geraniol encapsulated by pH/redox-responsive nanogel ameliorates osteoarthritis by regulating oxidative stress and inflammation
Intra-articular delivery of geraniol encapsulated by pH/redox-responsive nanogel ameliorates osteoarthritis by regulating oxidative stress and inflammation
Osteoarthritis (OA) remains a challenging condition due to limited drug bioavailability within the avascular and dense car...
The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing
The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing
Alpha-calcitonin gene-related peptide (αCGRP) and substance P (SP) are functionally correlated sensory neuropeptides ...
Serum HBV RNA levels among untreated adults with chronic hepatitis B in distinct immune phases and liver histopathology statuses
Serum HBV RNA levels among untreated adults with chronic hepatitis B in distinct immune phases and liver histopathology statuses
HBV RNA is a novel serum biomarker that reflects intrahepatic HBV covalently closed circular DNA (cccDNA) transcription ac...
Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation
Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation
Increasing evidence has indicated that the Golgi apparatus (GA) is involved in the development of cerebral ischemia–...
Dynamic patterns of histone lactylation during early tooth development in mice
Dynamic patterns of histone lactylation during early tooth development in mice
Histone lactylation on its lysine (K) residues has been reported to have indispensable roles in lung fibrosis, embryogenes...
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway
Endoplasmic reticulum oxidoreductin 1α (ERO1α) is an oxidase that exists in the endoplasmic reticulum and plays ...
Three-dimensional visualization of the lymphatic, vascular and neural network in rat lung by confocal microscopy
Three-dimensional visualization of the lymphatic, vascular and neural network in rat lung by confocal microscopy
In order to demonstrate the intricate interconnection of pulmonary lymphatic vessels, blood vessels, and nerve fibers, the...
USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination
USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination
Cancer cell stemness contributes significantly to intrahepatic cholangiocarcinoma (ICC) progression. However, the roles of...
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs
Sepsis is a serious inflammatory disease caused by bacterial infection. Cardiovascular dysfunction and remodeling are seri...
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