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A bacterial neoantigen cancer vaccine
Neoantigen cancer vaccines hold great promise for cancer treatment but are often limited by the immunosuppressive tumor en...
First proof-of-mechanism for RNA editing in humans
The first clinical results for an RNA-editing oligonucleotide designed to correct a disease-causing single-base mutation i...
Shot in the arm for biotech fuels
The US Department of Energy (DOE) in October conditionally committed nearly $3 billion to two companies to scale up the pr...
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Directed evolution of engineered virus-like particles with improved production and transduction efficiencies
Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene...
Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Editor’s pick: Gate Bioscience
Editor’s pick: Gate Bioscience
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year....
Bezos backs taste-good lab proteins
Jeff Bezos is bankrolling two new centers to research and develop sustainable proteins that taste good and can be produced...
Precise and versatile genome editing with click editors
Precise and versatile genome editing with click editors
We developed click editors, comprising HUH endonucleases, DNA-dependent DNA polymerases and CRISPR–Cas9 nickases, wh...
Editor’s pick: Indapta Therapeutics
Editor’s pick: Indapta Therapeutics
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year....
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases
Genome editing technologies based on DNA-dependent polymerases (DDPs) could offer several benefits compared with other typ...
Author Correction: Quantifying bias introduced by sample collection in relative and absolute microbiome measurements
In the original published version of this article, there was a 10-fold error in the 16S rRNA gene standard curves. This wa...
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants
Population-scale databases have expanded to millions of protein-coding variants, yet insight into their mechanistic conseq...
A mini-colon models colon cancer and its microenvironment
A mini-colon models colon cancer and its microenvironment
A mini-colon device mimics colorectal tumors and their interactions with neighboring healthy tissue, stromal cells and imm...
Supercharging T cell therapy with cancer mutations
T cell therapies are still hindered by poor T cell persistence and function, making them largely ineffective against solid...
US bill targets Chinese biotechs
The United States is seeking to prevent four Chinese biotech companies from doing business in the country, citing them as ...
A retrotransposon for site-specific gene transfer
A retrotransposon for site-specific gene transfer
An engineered retrotransposon achieves targeted gene transfer into the human genome.
Making genome editing a success story in Africa
Making genome editing a success story in Africa
Mistrust surrounding genetic engineering — fed by ethical concerns, fears of unintended consequences and a lack of transpa...
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Spatially resolved gene expression profiling provides insight into tissue organization and cell–cell crosstalk; howe...
De novo and somatic structural variant discovery with SVision-pro
De novo and somatic structural variant discovery with SVision-pro
Long-read-based de novo and somatic structural variant (SV) discovery remains challenging, necessitating genomic compariso...
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limite...
Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
Department Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, USAJohannes L. Zakrzewski, David Suh, O...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
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