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Supercharging T cell therapy with cancer mutations
T cell therapies are still hindered by poor T cell persistence and function, making them largely ineffective against solid...
US bill targets Chinese biotechs
The United States is seeking to prevent four Chinese biotech companies from doing business in the country, citing them as ...
A retrotransposon for site-specific gene transfer
A retrotransposon for site-specific gene transfer
An engineered retrotransposon achieves targeted gene transfer into the human genome.
Making genome editing a success story in Africa
Making genome editing a success story in Africa
Mistrust surrounding genetic engineering — fed by ethical concerns, fears of unintended consequences and a lack of transpa...
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Spatially resolved gene expression profiling provides insight into tissue organization and cell–cell crosstalk; howe...
De novo and somatic structural variant discovery with SVision-pro
De novo and somatic structural variant discovery with SVision-pro
Long-read-based de novo and somatic structural variant (SV) discovery remains challenging, necessitating genomic compariso...
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limite...
Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
Department Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, USAJohannes L. Zakrzewski, David Suh, O...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
A bacterial assist for CAR-T cells
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Precise intraoperative brain tumor classification
Central nervous system (CNS) tumors are a leading cause of cancer-related deaths, particularly among children, and the pri...
Antibody engineering
Recent patents relating to the manufacture and design of engineered immunoglobulin polypeptides.
NKs for lupus poised for trial
Nkarta is charting a course for its allogeneic chimeric antigen receptor (CAR) natural killer cell (NK) therapy in autoimm...
Chan Zuckerberg hubs multiply
In October, the Chan Zuckerberg Initiative (CZI) launched two new biohubs: one in New York and another in Chicago. The bio...
Most effective malaria vaccine yet
A new malaria vaccine for children is the first to meet the World Health Organization’s (WHO) 75% protection target. The v...
Brain imaging turned inside out
Brain imaging turned inside out
Neural connectivity in brain tissue is imaged by labeling the extracellular space.
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are commo...
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