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The structural biology of type III CRISPR-Cas systems
The structural biology of type III CRISPR-Cas systems
The CRISPR-Cas system is a widespread RNA-guided adaptive immune system found in both bacteria (50 %) and archaea (90 %) (...
MarkerDetector: A method for robust fiducial marker detection in electron micrographs using wavelet-based template
MarkerDetector: A method for robust fiducial marker detection in electron micrographs using wavelet-based template
Electron tomography (ET) is an important tool for investigating the internal organization of cells at a resolution of a fe...
A deep learning approach to the automatic detection of alignment errors in cryo-electron tomographic reconstructions
A deep learning approach to the automatic detection of alignment errors in cryo-electron tomographic reconstructions
Electron tomography is an imaging technique that allows for the elucidation of three-dimensional structural information of...
Cryo-forum: A framework for orientation recovery with uncertainty measure with the application in cryo-EM image analysis
Cryo-forum: A framework for orientation recovery with uncertainty measure with the application in cryo-EM image analysis
Proteins, which are large and intricate molecules, are fundamental to all forms of life and perform a plethora of function...
DeepQs: Local quality assessment of cryo-EM density map by deep learning map-model fit score
DeepQs: Local quality assessment of cryo-EM density map by deep learning map-model fit score
In recent years, there has been a tremendous increase in the number of high-resolution 3D macromolecular maps generated by...
Accurate, automatic determination of astigmatism and phase with Ctfplotter in IMOD
Accurate, automatic determination of astigmatism and phase with Ctfplotter in IMOD
Cryo-electron tomography (cryoET) with subtomogram averaging has proved to be a powerful method for determining molecular ...
Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation
Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation
Prenyltransferases are crucial biosynthetic enzymes found in all branches of life. In primary metabolism, prenyltransferas...
A strained N-capping motif in α-helices of βαβ-units
A strained N-capping motif in α-helices of βαβ-units
The N-cap and C-cap are amino acid residues that form the first and last hydrogen bonds between the α-helix backbone amide...
Focused ion beam-SEM 3D study of osteodentin in the teeth of the Atlantic wolfish Anarhichas lupus
Focused ion beam-SEM 3D study of osteodentin in the teeth of the Atlantic wolfish Anarhichas lupus
The evolutionary histories of dentin and bone are closely intertwined and must be considered together(Sire and Kawasaki, 2...
Characterization of a new extra-axonemal structure in the Giardia intestinalis flagella
Characterization of a new extra-axonemal structure in the Giardia intestinalis flagella
Giardia intestinalis is a parasite that causes giardiasis, a diarrheal disease in humans and animals. It is one of the mos...
Control of crystal growth during coccolith formation by the coccolithophore Gephyrocapsa oceanica
Control of crystal growth during coccolith formation by the coccolithophore Gephyrocapsa oceanica
KeywordsCoccolithophores, biomineralization, cryo-transmission electron microscopyFocused-ion beam scanning electron micro...
Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis
Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis
AbbreviationsFabHβ-Ketoacyl-ACP synthase IIIFASIIbacterial fatty acid synthesisKeywordsBacillus subtilisFabHAFabHBCrystal ...
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite
T. Gopinath: . Kyungsoo Shin: Writing – review & editing, Writing – original draft, Formal analysis, Data curation. Ye...
Deep Generative Priors for Biomolecular 3D Heterogeneous Reconstruction from Cryo-EM Projections
Deep Generative Priors for Biomolecular 3D Heterogeneous Reconstruction from Cryo-EM Projections
KeywordsSingle-particle analysisCryogenic electron microscopyProtein conformational variationDeep generative modelsData av...
Effects of Xylanase A double mutation on substrate specificity and structural dynamics
Effects of Xylanase A double mutation on substrate specificity and structural dynamics
Enzyme activity is traditionally studied with a major focus on the active site and how its structure contributes to the en...
Comprehensive structural overview of the C-terminal ligand-binding domains of the TetR family regulators
Comprehensive structural overview of the C-terminal ligand-binding domains of the TetR family regulators
TetR family regulators (TFRs) represent a large group of one-component bacterial signal transduction systems which recogni...
ColabSeg: An interactive tool for editing, processing, and visualizing membrane segmentations from cryo-ET data
ColabSeg: An interactive tool for editing, processing, and visualizing membrane segmentations from cryo-ET data
KeywordsCryo-electron tomography (Cryo-ET)Electron microscopySegmentationLipid membranesImage analysisData availabilityThe...
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information
Single particle cryo-electron microscopy (cryo-EM) is a technique that can provide detailed structural information on the ...
Exploring the Folding Landscape of Leptin: Insights into Threading Pathways
Exploring the Folding Landscape of Leptin: Insights into Threading Pathways
In the last 30 years, the role of protein topology has emerged with increased interest as new entanglements and loop cross...
The 3D organization of the mineralized scales of the sturgeon has structures reminiscent of dentin and bone: A FIB-SEM study
The 3D organization of the mineralized scales of the sturgeon has structures reminiscent of dentin and bone: A FIB-SEM study
Bone of dermal origin is considered to be phylogenetically older than bone that forms the endoskeleton as no mineralized t...
Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases
Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases
Lactate dehydrogenases (LDHs) (EC 1.1.1.27) and Malate dehydrogenases (MalDHs) (EC 1.1.1.37) belong to a wide group of 2-k...
Classification of helical polymers with deep-learning language models
Classification of helical polymers with deep-learning language models
Many macromolecules in biological systems exist in the form of helical polymers, such as amyloid fibrils (Fitzpatrick et a...
From in-silico screening to in-vitro evaluation: Enhancing the detection of Microcystins with engineered PP1 mutant variants
From in-silico screening to in-vitro evaluation: Enhancing the detection of Microcystins with engineered PP1 mutant variants
Ensuring the innocuity and quality of water is a pressing challenge in a world where the anthropogenic footprint has reach...
Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM
Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM
KeywordsSuper-resolutionCorrelative light and electron microscopycryoCLEMSingle Particle AnalysisData availabilityThe cryo...
Predicting virus Fitness: Towards a structure-based computational model
Predicting virus Fitness: Towards a structure-based computational model
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Cevik et al., 2020, Wu et al., 2020, ...
Crystal Structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG
Crystal Structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG
Keywordsσ / anti-σ pairStreptomyces tsukubaensisCrystal structuresECF56Data availabilityPDB references: Streptomyces tsuku...
Announcement: Journal of Structural Biology- Paper of the Year 2022
Announcement: Journal of Structural Biology- Paper of the Year 2022
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Morphological and genetic mechanisms underlying the plasticity of the coral Porites astreoides across depths in Bermuda
Morphological and genetic mechanisms underlying the plasticity of the coral Porites astreoides across depths in Bermuda
Tropical coral reefs have undergone global declines due to rapidly changing climate and the accumulation of anthropogenic ...
Beyond the Surface: Investigation of Tumorsphere morphology using volume electron microscopy
Beyond the Surface: Investigation of Tumorsphere morphology using volume electron microscopy
The advent of volume electron microscopy (vEM) has provided unprecedented insights into cellular and subcellular organizat...
Sulisobenzone is a potent inhibitor of the global transcription factor Cra
Sulisobenzone is a potent inhibitor of the global transcription factor Cra
Prokaryotes have elaborate mechanisms to deal with the regulation of the gene expression process by the action of the tran...
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