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Emerging rejuvenation strategies—Reducing the biological age
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Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
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Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration
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Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation
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Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
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Late‐life exercise mitigates skeletal muscle epigenetic aging
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The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish
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Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy
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Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
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A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis
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Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
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Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
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Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span
Abstract Diet regulates complex life-history traits such as longevity. For optimal lifespan, organisms employ intricate ad...
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Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging
Abstract DNA methylation alterations play mechanistic roles in aging; however, the epigenetic regulators/mediators causall...
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Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes
Abstract Metformin, the most commonly prescribed anti-diabetes medication, has multiple reported health benefits, includin...
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Phenotype correlations reveal the relationships of physiological systems underlying human ageing
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Nogo receptor impairs the clearance of fibril amyloid‐β by microglia and accelerates Alzheimer’s‐like disease progression
Abstract Alzheimer's disease (AD) is characterized by the progressive accumulation of β-amyloid (Aβ)-containin...
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Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
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Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice
Abstract The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying liver aging remain unclear....
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α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
Abstract The cell-to-cell transfer of α-synuclein (α-Syn) greatly contributes to Parkinson's disease (PD) path...
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Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging
Abstract Somatopause refers to the gradual declines in growth hormone (GH) and insulin-like growth factor-1 throughout agi...
Aging Cell
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α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
Abstract SNCA protein product, α-synuclein, is widely renowned for its role in synaptogenesis and implication in bot...
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Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies
Abstract Age-related memory impairment (AMI) occurs in many species, including humans. The underlying mechanisms are not f...
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Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease
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Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation
Abstract Adiponectin (APN) deficiency has also been associated with Alzheimer-like pathologies. Recent studies have illumi...
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miR‐125a‐5p increases cellular DNA damage of aging males and perturbs stage‐specific embryo development via Rbm38‐p53 signaling
Abstract An increasing number of men are fathering children at an older age than in the past. While advanced maternal age ...
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Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
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