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Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Clinical samples are irreplaceable, and their transformation into searchable and reusable digital biobanks is critical for...
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycopr...
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Colorectal Cancer (CRC) is a prevalent form of cancer, and the effectiveness of the main postoperative chemotherapy treatm...
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Bio...
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
Cell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interact...
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Metabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is als...
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), t...
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver ...
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) ...
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
The organ perfusion solution (perfusate), collected at clinically and temporally significant stages of the organ preservat...
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
The tyrosine kinase inhibitor sunitinib is an effective first-line treatment for patients with advanced renal cell carcino...
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
Prostate cancer (PCa) is the second most common cancer in males worldwide. The risk stratification of PCa is mainly based ...
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Histones posttranslational modification represent an epigenetic mechanism that regulate gene expression and other cellular...
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understa...
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed...
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-...
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement, especially the kidneys. Howev...
Redefining serological diagnostics with immunoaffinity proteomics
Redefining serological diagnostics with immunoaffinity proteomics
Serological diagnostics is generally defined as the detection of specific human immunoglobulins developed against viral, b...
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors
Meningiomas are the most prevalent primary brain tumors. Due to their increasing burden on healthcare, meningiomas have be...
Development of an ID-LC–MS/MS method using targeted proteomics for quantifying cardiac troponin I in human serum
Development of an ID-LC–MS/MS method using targeted proteomics for quantifying cardiac troponin I in human serum
Cardiac troponin is a complex protein consisting of the three subunits I, T and C located in heart muscle cells. When the ...
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. New drug targets and proteins that would assi...
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
The molecular pathology of diffuse large B cell lymphoma (DLBCL) has been extensively studied. Among DLBCL subtypes, the p...
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy
Differentiating between a normal intrauterine pregnancy (IUP) and abnormal conditions including early pregnancy loss (EPL)...
New mechanisms and biomarkers of lymph node metastasis in cervical cancer: reflections from plasma proteomics
New mechanisms and biomarkers of lymph node metastasis in cervical cancer: reflections from plasma proteomics
Lymph node metastasis (LNM) and lymphatic vasculature space infiltration (LVSI) in cervical cancer patients indicate a poo...
Correction to: Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis
Correction to: Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis
Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis
Multiple sclerosis (MS) remains a highly unpredictable disease. Many hope that fluid biomarkers may contribute to better s...
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various disciplines of laboratory medicine t...
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disea...
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis
The detection of SARS-CoV-2 biomarkers by real time PCR (rRT-PCR) has shown that the sensitivity of the test is negatively...
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