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Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment
Multi-omics analyses, cell experiments, and network pharmacology tools identified key proteins and candidate drugs for alopecia areata treatment
Alopecia Areata (AA) is an inflammatory non-cicatricial alopecia with a high prevalence. Some patients with AA show an inf...
Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer
Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer
Identifying the population at risk of rapid progression from hormone-sensitive prostate cancer (HSPC) to lethal castration...
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis
There is insufficient attention to the pathogenesis of abnormal radiological changes and molecular mechanism in the parasp...
Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study
Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study
The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has...
Decreased proliferation of HepG2 liver cancer cells in vitro and exhibited proteomic changes in vivo in subjects with metabolic syndrome and metabolic dysfunction-associated steatotic liver disease who performed four-week dawn-to-dusk dry fasting
Decreased proliferation of HepG2 liver cancer cells in vitro and exhibited proteomic changes in vivo in subjects with metabolic syndrome and metabolic dysfunction-associated steatotic liver disease who performed four-week dawn-to-dusk dry fasting
Four-week dawn-to-dusk dry fasting (DDDF) was previously shown to have a potent anti-inflammatory effect and induce an ant...
SPOT: spatial proteomics through on-site tissue-protein-labeling
SPOT: spatial proteomics through on-site tissue-protein-labeling
Spatial proteomics seeks to understand the spatial organization of proteins in tissues or at different subcellular localiz...
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities
COVID19 is a pandemic that has affected millions around the world since March 2020. While many patients recovered complete...
Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers
Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers
Mucosal healing is the therapeutic target for ulcerative colitis (UC). While amino acids (AAs) and the gut microbiota are ...
Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling
Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling
Alternative N-glycosylation of serum proteins has been observed in colorectal cancer (CRC), esophageal squamous cell carci...
Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target
Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target
The vitreous humor serves as a window into the physiological and pathological processes of the eye, particularly the retin...
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To en...
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insigh...
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA
Clinical samples are irreplaceable, and their transformation into searchable and reusable digital biobanks is critical for...
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycopr...
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Colorectal Cancer (CRC) is a prevalent form of cancer, and the effectiveness of the main postoperative chemotherapy treatm...
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas
Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Bio...
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
Cell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interact...
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Metabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is als...
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), t...
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver ...
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) ...
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
The organ perfusion solution (perfusate), collected at clinically and temporally significant stages of the organ preservat...
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
The tyrosine kinase inhibitor sunitinib is an effective first-line treatment for patients with advanced renal cell carcino...
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
Prostate cancer (PCa) is the second most common cancer in males worldwide. The risk stratification of PCa is mainly based ...
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Histones posttranslational modification represent an epigenetic mechanism that regulate gene expression and other cellular...
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understa...
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed...
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-...
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement, especially the kidneys. Howev...
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