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Decision architecture randomisation: extremely efficient clinical trials that preserve clinician and patient choice?
Decision architecture randomisation: extremely efficient clinical trials that preserve clinician and patient choice?
Healthcare is full of choices between standard-of-care approaches where one might be better but we do not know which. Exam...
The Six Steps of SDM: linking theory to practice, measurement and implementation
The Six Steps of SDM: linking theory to practice, measurement and implementation
Shared decision-making (SDM) has gained acceptance as a preferred and ideal method for medical decision-making.1 2 As SDM ...
Towards transparency: adoption of WHO best practices in clinical trial registration and reporting among top medical research funders in the USA
Towards transparency: adoption of WHO best practices in clinical trial registration and reporting among top medical research funders in the USA
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Patient-reported effects of hospital-wide implementation of shared decision-making at a university medical centre in Germany: a pre-post trial
Patient-reported effects of hospital-wide implementation of shared decision-making at a university medical centre in Germany: a pre-post trial
IntroductionShared decision-making (SDM) is considered the apex of patient-centred, evidence-based healthcare. Much has be...
Does the format of result presentation and type of conclusion in Cochrane plain language summaries matter? A randomised controlled trial
Does the format of result presentation and type of conclusion in Cochrane plain language summaries matter? A randomised controlled trial
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Catalogue of bias: racial bias
Catalogue of bias: racial bias
Racial bias is a distortion arising from systemic, institutional, interpersonal or individual forms of explicit (conscious...
Introduction of allergenic food to infants and allergic and autoimmune conditions: a systematic review and meta-analysis
Introduction of allergenic food to infants and allergic and autoimmune conditions: a systematic review and meta-analysis
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Reducing the residue of retractions in evidence synthesis: ways to minimise inappropriate citation and use of retracted data
Reducing the residue of retractions in evidence synthesis: ways to minimise inappropriate citation and use of retracted data
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSAuthors, editors, publishers, research institutions, funding agenci...
Visualisation of evidence for shared decision making
Visualisation of evidence for shared decision making
Why does it matter?Consistent with the principles of evidence-based medicine, effectively communicating evidence (includin...
Talk to me, but rather: talk to each other
Talk to me, but rather: talk to each other
During a yearly routine check-up for my alopecia in a hospital on the other side of the country, a small cancerous mass wa...
When does the placebo effect have an impact on network meta-analysis results?
When does the placebo effect have an impact on network meta-analysis results?
IntroductionMany definitions have been proposed for placebo, from ‘a medicine given more to please than to benefit’ in the...
Dynamic intervention strategies await inclusion in clinical evidence synthesis
Dynamic intervention strategies await inclusion in clinical evidence synthesis
In the first half of this year, an article about the next generation of evidence-based medicine1 was published in Nature  ...
Is a one-size-fits-all '12-month rule appropriate when it comes to the last search date in systematic reviews?
Is a one-size-fits-all '12-month rule appropriate when it comes to the last search date in systematic reviews?
SRs are a recognised research approach for identifying, synthesising and analysing published evidence on topics of interes...
Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
Because individual patients weigh benefits and harms differently, it is important to provide quantitative information abou...
Living health technology assessments: how close to living reality?
Living health technology assessments: how close to living reality?
IntroductionHealthcare decision-makers are exploring more responsive, innovative processes in the wake of the COVID-19 pan...
Detection bias in open-label trials of anticancer drugs: a meta-epidemiological study
Detection bias in open-label trials of anticancer drugs: a meta-epidemiological study
are validated by studies that overcome this limitation, it is desirable to establish central reviewers in oncological open...
Piloting a new method to estimate action thresholds in medicine through intuitive weighing
Piloting a new method to estimate action thresholds in medicine through intuitive weighing
IntroductionThe threshold approach in clinical decision-makingWhen confronted with diagnostic uncertainty clinicians will ...
Re-evaluating the role of pilot trials in informing effect and sample size estimates for full-scale trials: a meta-epidemiological study
Re-evaluating the role of pilot trials in informing effect and sample size estimates for full-scale trials: a meta-epidemiological study
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Cleara...
Bias, quality and reporting in health research: differences and tools for appraisal
Bias, quality and reporting in health research: differences and tools for appraisal
Bias is generally defined as a systematic error or deviation from the truth in research results, which leads to underestim...
Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial
Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial
IntroductionFunctional dyspepsia is a frequently occurring disorder that can be caused by a variety of factors, with no ev...
Rapid reviews methods series: Guidance on literature search
Rapid reviews methods series: Guidance on literature search
WHAT IS ALREADY KNOWN ON THIS TOPICCompared with systematic reviews, rapid reviews (RR) often abbreviate or limit the lite...
Catalogue of bias: novelty bias
Catalogue of bias: novelty bias
Novelty bias is the tendency for an intervention to appear better when it is new. It is also known as the ‘novel agent eff...
How caring for my child with cancer changed my approach to clinical care and research
How caring for my child with cancer changed my approach to clinical care and research
I am a clinical psychologist who specialises in helping children with medical illnesses and their families. I am also a mo...
Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment
Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment
WHAT IS ALREADY KNOWN ON THIS TOPICCompared with full systematic reviews, rapid reviews (RRs) often omit dual processes or...
Relationship between the conflicts of interest and the results of meta-analyses of homoeopathy trials
Relationship between the conflicts of interest and the results of meta-analyses of homoeopathy trials
In the absence of robust trials supporting the efficacy of homoeopathy, people who criticise or, on the contrary, defend h...
Exploring advanced methods for network meta-analysis
Exploring advanced methods for network meta-analysis
High-quality systematic reviews (SRs) of both new and existing health technologies are vital to inform clinical practices ...
What is the place in therapy for nirmatrelvir/ritonavir?
What is the place in therapy for nirmatrelvir/ritonavir?
The COVID-19 pandemic presents substantial challenges for governments and providers keen to provide effective treatments. ...
Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology
Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology
Shared decision making and service designTreatment decision-making can be complex, notably when there are multiple treatme...
Challenges to delivering evidence-based management for long COVID
Challenges to delivering evidence-based management for long COVID
Early on in the COVID-19 pandemic, scientists forewarned of a potential medium to long-term post-acute sequelae in patient...
Plain language summaries: enhancing patient-centred care and improving accessibility of health research
Plain language summaries: enhancing patient-centred care and improving accessibility of health research
As part of the Open Science movement, plain language summaries (PLSs) could make scientific research more understandable a...
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