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Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland
Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland
In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary signifi...
The impact of long COVID on health-related quality of life in patients 6 months after discharge with severe COVID-19
The impact of long COVID on health-related quality of life in patients 6 months after discharge with severe COVID-19
This study investigates the relationship between long COVID and health-related quality of life (HRQOL) in patients dischar...
Costimulatory receptors in the channel catfish: CD28 family members and their ligands
Costimulatory receptors in the channel catfish: CD28 family members and their ligands
The CD28-B7 interaction is required to deliver a second signal necessary for T-cell activation. Additional membrane recept...
Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation
Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation
Microglia cells are activated in response to different stress signals. Several metabolic adaptations underlie microglia ac...
Determination for KIR genotype and allele copy number via real-time quantitative PCR method
Determination for KIR genotype and allele copy number via real-time quantitative PCR method
Killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) play crucial roles in regulating NK cell ...
Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells
Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of...
Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles
Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles
In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding...
Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study
Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on blood pressure using Mendelian...
Lack of Syndecan-1 promotes the pathogenesis of experimental rheumatoid arthritis
Lack of Syndecan-1 promotes the pathogenesis of experimental rheumatoid arthritis
Syndecan-1 (Sdc-1), a transmembrane heparan sulfate protein, is implicated in several pathophysiological processes includi...
A novel hemizygous CD40L mutation of X-linked hyper IgM syndromes and compound heterozygous DOCK8 mutations of hyper IgE syndromes in two Chinese families
A novel hemizygous CD40L mutation of X-linked hyper IgM syndromes and compound heterozygous DOCK8 mutations of hyper IgE syndromes in two Chinese families
X-linked hyper-immunoglobulin M (X-HIGM) syndrome and autosomal recessive hyper-immunoglobulin E syndrome (HIES) are rare ...
Evolutionary divergence of TLR9 through ancestral sequence reconstruction
Evolutionary divergence of TLR9 through ancestral sequence reconstruction
The transmembrane pattern recognition receptor, Toll-like receptor (TLR), are best known for their roles in innate immunit...
Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto’s thyroiditis in a group of Iranian patients
Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto’s thyroiditis in a group of Iranian patients
One of the probable hypotheses for the onset of autoimmunity is molecular mimicry. This study aimed to determine the HLA-I...
B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study
B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study
Hypogammaglobulinemia without B-cells is a subgroup of inborn errors of immunity (IEI) which is characterized by a signifi...
Immunoglobulin genes and severity of COVID-19
Immunoglobulin genes and severity of COVID-19
There is tremendous interindividual and interracial variability in the outcome of SARS-CoV-2 infection, suggesting the inv...
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of auto...
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. ...
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Yersinia pestis is a historically important vector-borne pathogen causing plague in humans and other mammals. Contemporary...
The KIR2DL1 intermediate upstream element participates in gene activation
The KIR2DL1 intermediate upstream element participates in gene activation
The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of ...
Macroevolution of avian T cell receptor C segments using genomic data
Macroevolution of avian T cell receptor C segments using genomic data
All jawed vertebrates have four T cell receptor (TCR) chains expressed by thymus-derived lymphocytes that play a significa...
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based ...
Genomic view of the origins of cell-mediated immunity
Genomic view of the origins of cell-mediated immunity
NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)–type immunoglobulin super...
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Regulating natural killer (NK) cell responses in hematological malignancies largely depend on molecular interactions betwe...
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Since its initial discovery over 50 years ago, understanding the evolution of the vertebrate RAG- mediated adapti...
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
T-helper 17 (Th17) cells are a subset of CD4+ helper T cells that produce interleukin 17 (IL-17) and play a crucial role i...
Prof. Dr. Jan Klein (1936-2023)
Prof. Dr. Jan Klein (1936-2023)
Jan Klein was born in 1936 in Stemplovec, a small town in the Czech Republic. Quite f...
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Controlling CD4+ immune cell infiltration of the brain is a leading aim in designing therapeutic strategies for a range of...
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and sim...
Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis
Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis
The programmed death-1 (PD-1) pathway has been shown to deliver an inhibitory signal, and aberrant expression of the PD-1 ...
Correction to: Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Correction to: Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
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