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KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis
KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis
Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent insights into ferroptosis have opened new avenue...
Microglial activation is inhibited by selective anti-seizure medications
Microglial activation is inhibited by selective anti-seizure medications
To investigate the anti-inflammatory properties of anti-seizure medications (ASMs) administered to patients with drug-resi...
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming
Pulmonary inflammation is closely associated with macrophage polarization and lipid metabolic reprogramming. Miconazole (M...
Advances in fibroblast-based cardiac reprogramming in the treatment of heart disease
Advances in fibroblast-based cardiac reprogramming in the treatment of heart disease
Due to population aging and a wide range of risk factors, coupled with the limited regenerative capacity of the myocardium...
Impact of sepsis on bone marrow mesenchymal stem cells and its implications for hematopoiesis and immunosuppression
Impact of sepsis on bone marrow mesenchymal stem cells and its implications for hematopoiesis and immunosuppression
Septic patients often exhibit disruption of the normal hematopoiesis, leading to hematological abnormalities such as anaem...
A systematic review of novel Phosphodiesterase-4 inhibitors in the treatment of psoriasis
A systematic review of novel Phosphodiesterase-4 inhibitors in the treatment of psoriasis
Psoriasis is a chronic immune-mediated skin disease that significantly impacts patients’ quality of life due to its ...
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis
Interleukin-17 (IL-17) has emerged as a key cytokine at the intersection of inflammation and thrombosis, potentially playi...
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress
Sepsis-Associated Encephalopathy (SAE) is a severe neurological complication of sepsis, where neuroinflammation plays a cr...
Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study
Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study
Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recogn...
Mechanistic study on the inhibition of triple-negative breast cancer progression by LncRNA TFAP2A-AS1 through the regulation of miR-6892/PHGDH
Mechanistic study on the inhibition of triple-negative breast cancer progression by LncRNA TFAP2A-AS1 through the regulation of miR-6892/PHGDH
The roles of long non-coding RNAs (lncRNAs) in the progression of various human tumors have been extensively studied. Howe...
The role of absent in melanoma 2 (AIM2) in cardiovascular diseases
The role of absent in melanoma 2 (AIM2) in cardiovascular diseases
Cardiovascular diseases (CVDs) are a group of conditions that significantly affect human health and are among the leading ...
Histamine regulates the activity and the expression of the Na/H exchanger (NHE)3 in human epithelial HK-2 cells
Histamine regulates the activity and the expression of the Na/H exchanger (NHE)3 in human epithelial HK-2 cells
Investigate the potential role of histamine and its receptors on the functional expression of the sodium/hydrogen (Na+/H+)...
Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives
Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives
Itaconate, a mitochondrial metabolite generated from cis-aconitate via IRG1 (ACOD1), has emerged as a key immunometabolic ...
Cannabinoids in preclinical research of sepsis: a scoping review
Cannabinoids in preclinical research of sepsis: a scoping review
Sepsis is a global health problem that ends millions of lives and costs billions of dollars in treatment and management ev...
Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context
Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context
Traumatic spinal cord injury (SCI) is a severe clinical challenge, often leading to long-term sensory, motor, and autonomi...
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression
Xiaoqinglong Decoction (XQLD) is a traditional oriental medicine. Modified- Xiaoqinglong Decoction (M-XQLD) was establishe...
The impact of aspirin on PD-L1 expression and alteration of M2 polarization in non-small cell lung cancer
The impact of aspirin on PD-L1 expression and alteration of M2 polarization in non-small cell lung cancer
Although aspirin is one of the best characterized drugs for the therapeutic effects on coagulation and inflammation, there...
Tuberculosis-infected macrophage exosomal miR-125b-5p induces osteoporosis by targeting IGF2 through the PI3K/AKT pathway
Tuberculosis-infected macrophage exosomal miR-125b-5p induces osteoporosis by targeting IGF2 through the PI3K/AKT pathway
Tuberculosis (TB) is a major infectious disease that can lead to systemic complications, including osteoporosis, particula...
A pain from the nose to the head: neurological commitment during long COVID
A pain from the nose to the head: neurological commitment during long COVID
Long COVID is a debilitating illness with multi-systemic symptoms that affects at least 10% of individuals who have had CO...
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
Chronic inflammation is well recognized as a key factor related to renal function deterioration in patients with diabetic ...
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Cardiovascular diseases (CVDs) continue to be a substantial global healthcare burden despite considerable progress in ther...
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy sup...
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
Particulate matter (PM) exposure has been proposed as one of the causes of steroid resistance. However, studies investigat...
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
This study seeks to elucidate the role and molecular mechanisms of IL-8 in nasal epithelial cell pyroptosis and its impact...
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized...
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
Hyperoxia-induced brain injury is a severe neurological complication that is often accompanied by adverse long-term progno...
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Sepsis-associated encephalopathy (SAE) often results from neuroinflammation. Recent studies have shown that brain platelet...
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane...
The role of celastrol in inflammation and diseases
The role of celastrol in inflammation and diseases
Celastrol is one of the main active ingredients extracted from the plant Tripterygium wilfordii Hook F. A growing number o...
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Hypertrophic scar (HS) is a severe skin fibrosis. Transplanting stem cells carrying anti-fibrotic cytokine genes, like int...
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