SCI Abstract

search
+
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
Chronic inflammation is well recognized as a key factor related to renal function deterioration in patients with diabetic ...
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Cardiovascular diseases (CVDs) continue to be a substantial global healthcare burden despite considerable progress in ther...
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy sup...
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
Particulate matter (PM) exposure has been proposed as one of the causes of steroid resistance. However, studies investigat...
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
This study seeks to elucidate the role and molecular mechanisms of IL-8 in nasal epithelial cell pyroptosis and its impact...
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized...
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
Hyperoxia-induced brain injury is a severe neurological complication that is often accompanied by adverse long-term progno...
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Sepsis-associated encephalopathy (SAE) often results from neuroinflammation. Recent studies have shown that brain platelet...
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane...
The role of celastrol in inflammation and diseases
The role of celastrol in inflammation and diseases
Celastrol is one of the main active ingredients extracted from the plant Tripterygium wilfordii Hook F. A growing number o...
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Hypertrophic scar (HS) is a severe skin fibrosis. Transplanting stem cells carrying anti-fibrotic cytokine genes, like int...
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage
Sclerostin (SOST) is traditionally regarded as an osteocyte-derived secreted glycoprotein that regulates bone mineralizati...
Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice
Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice
We aimed to understand the potential therapeutic and anti-inflammatory effects of the phosphodiesterase-4 (PDE4) inhibitor...
ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration
ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration
One of the etiologic components of degenerative spinal illnesses is intervertebral disc degeneration (IVDD), and the accom...
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues
The aberrant expression of α defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the d...
Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells
Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells
In skin lesions of atopic dermatitis (AD), a chronic inflammatory skin disease, mast cells beyond other immune cells are p...
Silicone breast implant-associated pathologies and T cell-mediated responses
Silicone breast implant-associated pathologies and T cell-mediated responses
Silicone breast implants elicit a foreign body response (FBR) defined by a complex cascade of various immune cells. Studie...
HMGB1: key mediator in digestive system diseases
HMGB1: key mediator in digestive system diseases
High Mobility Group Box 1 (HMGB1), a multifunctional non-histone protein, and its involvement in various physiological and...
Serine metabolism in macrophage polarization
Serine metabolism in macrophage polarization
Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of ...
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Atherosclerosis, characterized by abnormal arterial lipid deposition, is an age-dependent inflammatory disease and contrib...
Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
Oncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with up...
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by hyperplastic synovium, pannus formation, immun...
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
Increased O-linked β-N-acetylglucosamine (O-GlcNAc) stimulation has been reported to protect against sepsis associate...
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Sepsis may often result in acute lung injury (ALI), with a high mortality and morbidity. Available evidence indicates that...
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Postoperative cognitive dysfunction (POCD) is a neurological complication occurring after anesthesia and surgery. Neuroinf...
Effects of neutrophil fate on inflammation
Effects of neutrophil fate on inflammation
Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infe...
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
Kidney stones commonly occur with a 50% recurrence rate within 5 years, and can elevate the risk of chronic kidne...
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typi...
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 muta...
Application of omics in Sjögren’s syndrome
Application of omics in Sjögren’s syndrome
The pathogenesis, diagnosis, and treatment of Sjögren’s syndrome (SS) face many challenges, and there is an urg...
Load More
format_indent_increase