SCI时时刷

search
+
Preparation and formulation of progesterone para-aminobenzoic acid co-crystals with improved dissolution and stability
Preparation and formulation of progesterone para-aminobenzoic acid co-crystals with improved dissolution and stability
The crystal structure of a new Progesterone (PROG) co-crystal with para-aminobenzoic acid (PABA) showing enhanced solution...
Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo
Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo
The discovery that the bacterial defense mechanism, CRISPR-Cas9, can be reprogrammed as a gene editing tool has revolution...
Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug
Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug
Glaucoma is a neurodegenerative disorder, which causes damage to the retinal ganglion cell and optic nerve in the posterio...
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
An inhalation-based Biopharmaceutics Classification System for pulmonary drugs (iBCS) holds the perspective to allow for s...
In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
Peptic ulcer disease (PUD) is one of the most common digestive disorder affecting the mucosal integrity of the stomach and...
Polymeric microneedles for the eye: An overview of advances and ocular applications for minimally invasive drug delivery
Polymeric microneedles for the eye: An overview of advances and ocular applications for minimally invasive drug delivery
Visual impairment and low visual acuity are global health concerns. The WHO reports that over 2.2 billion people suffer fr...
Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
Nucleic acids have been envisioned as a drug for decades. The development has faced early setbacks due to the risks associ...
Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements
Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements
KeywordsAnti-pollution productsCigarette smokeElectron paramagnetic resonance spectroscopyConfocal Raman microspectroscopy...
Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles
Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles
Neutral and positively charged archaeal ether lipids (AEL) have been studied for their utilization as novel delivery syste...
The role of phospholipids in drug delivery formulations – Recent advances presented at the Researcher’s Day 2023 Conference of the Phospholipid Research Center Heidelberg
The role of phospholipids in drug delivery formulations – Recent advances presented at the Researcher’s Day 2023 Conference of the Phospholipid Research Center Heidelberg
The Phospholipid Research Center (PRC) hosted its biennial Researcher's Day Conference from July 3–5, 2023, in Bad Dürkhei...
Rapid characterization of physical properties for the pharmaceutical pellet cores based on NIR spectroscopy and ensemble learning
Rapid characterization of physical properties for the pharmaceutical pellet cores based on NIR spectroscopy and ensemble learning
As one kind of the multi-particulate dosage forms, the sustained-release pellets are becoming increasingly popular due to ...
Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malaria
Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malaria
Malaria persists to be a prominent medical concern and poses a profound impact on health and socio-economic well-being acr...
Long acting tariquidar loaded stearic acid-modified hydroxyapatite enhances brain penetration and antitumor effect of temozolomide
Long acting tariquidar loaded stearic acid-modified hydroxyapatite enhances brain penetration and antitumor effect of temozolomide
Glioblastoma (GBM) is one of the most aggressive and common primary brain tumors in adults with median survival time less ...
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties
In the last decade, the incidence of bacterial skin infections has been increasing at an alarming pace, establishing an im...
Personalised oral dosage forms using an ultra-compact tablet press at the point of care
Personalised oral dosage forms using an ultra-compact tablet press at the point of care
Over the last 10 years there is an increasing need for the design of personalised medicines at the point of care (PoC) tha...
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury
Myocardial infarction is the leading cause of heart failure and mortality worldwide. While thrombolytic therapy and percut...
Kinetics of RNA-LNP delivery and protein expression
Kinetics of RNA-LNP delivery and protein expression
Lipid nanoparticles (LNPs) provide a facilitating platform for mRNA-based delivery [1], [2], [3]. The tremendous success o...
RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials
RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials
RNA-based therapeutics have been explored for a broad spectrum of applications, with clinical and FDA-approved drugs targe...
Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via Twin-Screw granulation for improved safety and effectiveness
Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via Twin-Screw granulation for improved safety and effectiveness
Opioids are frequently prescribed and considered effective for managing chronic pain, leading to a steady increase in thei...
Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
Over the last decades, lipid nanoparticles (LNPs) have evolved to become the most advanced nonviral platform for safe and ...
Enzymatic degradation pattern of polysorbate 20 impacts interfacial properties of monoclonal antibody formulations
Enzymatic degradation pattern of polysorbate 20 impacts interfacial properties of monoclonal antibody formulations
Polysorbate 20 (PS20) is widely used to maintain protein stability in biopharmaceutical formulations. However, PS20 is sus...
Comments on “Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water”
Comments on “Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water”
Volume 193, December 2023, Pages 306-307Author links open overlay panel, AbstractThis communication highlights the signifi...
Responses to comments on “Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water” (Eur. J. Pharm. Biopharm. 2023, 193, 1–15)
Responses to comments on “Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water” (Eur. J. Pharm. Biopharm. 2023, 193, 1–15)
Volume 193, December 2023, Pages 308-309Author links open overlay panel, Section snippetsDeclaration of Competing Interest...
Mucoactive drugs and multiple applications in pulmonary disease therapy
Mucoactive drugs and multiple applications in pulmonary disease therapy
In healthy individuals, mucus is secreted by airway epithelial cells and submucosal glands and plays a major role in preve...
Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology
Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consol...
Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells
Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. More effective and less toxic therapies are urgen...
Herbal active ingredient-loaded poly(ω-pentadecalactone-co-δ-valerolactone)/gelatin nanofibrous membranes
Herbal active ingredient-loaded poly(ω-pentadecalactone-co-δ-valerolactone)/gelatin nanofibrous membranes
Human skin keeps the internal fluid homeostasis and provides a barrier against damages caused by environmental factors (e....
Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations
Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations
Molecular mobility in form of alpha and beta relaxations is considered crucial for characterization of amorphous lyophiliz...
Multi-cavity molecular descriptor interconnections: Enhanced protocol for prediction of serum albumin drug binding
Multi-cavity molecular descriptor interconnections: Enhanced protocol for prediction of serum albumin drug binding
Human serum albumin (HSA) constitutes more than 60 % (by mass) of proteins in human blood plasma [1]. It is a monomeric, g...
Combination techniques towards novel drug delivery systems manufacturing: 3D PCL scaffolds enriched with tetracycline-loaded PVP nanoparticles
Combination techniques towards novel drug delivery systems manufacturing: 3D PCL scaffolds enriched with tetracycline-loaded PVP nanoparticles
The additive manufacturing, in which two or more materials come together and the structures are formed with a 3D printer, ...
阅读更多
format_indent_increase