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Functional nucleic acid-powered hybrid nanocarriers for synchronized targeted delivery of dual-solubility therapeutics
Combination chemotherapy for malignant tumors effectively overcomes monotherapy resistance through multi-pathway synergist...
Bak inserts into Mcl-1-puma and Mcl-1-BimL dimers to form hetero-trimers analyzed using quantitative live-cell FRET imaging
The B cell leukemia-2 (Bcl-2) protein family, including antiapoptotic members (Bcl-2, Bcl-xL, Bcl-w, Mcl-1, and A1) and pr...
Enhanced exogenous RNAi by loop-ended double-stranded RNA in plants
Exogenous RNA interference (exoRNAi) has emerged as a promising tool for gene silencing in plants, yet a robust and effici...
Cellular engineering strategies for soluble and secretory recombinant human insulin production in Pseudomonas fluorescens and batch bioreactor study
Diabetes, a metabolic disorder, ranks among the top 10 leading causes of death globally (Lin et al., 2020). Blood glucose ...
Efficient production of Ergothioneine via an optimized allogenous assembly of the ERG synthesis pathway in Escherichia coli BL21
Ergothioneine (ERG), also referred to as 2-mercaptohistidine trimethylbetaine, was initially discovered and isolated from ...
Integrative in-silico models for mammalian cell cultures in single-use bioreactors: Bridging hydrodynamics, kinetics, and process control across scales
Scaling-up of a bioprocess involves replicating the cell growth behavior observed in laboratory-scale vessels within large...
Improved methanol utilization of Komagataella phaffii by rebuilding metabolic network based on new alcohol-aldehyde transformation system
Methanol, as an alternative to sugar, is a renewable one-carbon source that can be obtained from CO2 or methane through ch...
Enhanced cascade biosynthesis of D-phenyllactic acid using metal-organic framework-encapsulated co-expressing E. coli
In recent years, rising living standards have made food safety a top consumer concern. The food industry mainly uses potas...
High-throughput flow cytometry-based titration of a live attenuated rotavirus vaccine
Vaccine potency is a critical quality attribute to ensure vaccine’s safety and efficacy. The standard potency assay for va...
Novel approaches to engineering autolysis: A scalable alternative for recovery of bioproducts.
For any bioprocess where the product is expressed intracellularly, cell lysis is an essential unit operation to release th...
Heterologous expression of L-lactate dehydrogenase in Chlorella pyrenoidosa: A beginning for poly(L-lactic acid) biosynthesis from CO2 by eukaryotic microalgae
Lactic acid has significant applications in food and beverage manufacturing (Rawoof et al., 2021), and it naturally occurs...
The CRISPR Cas patent files, part 3: Prime Editing and integrase-based variants
The epic patent disputes regarding CRISPR Cas9 and, to a lesser extent, CRISPR Cas12a, have somehow overcast a new patent ...
Characterization of 3D-printed acrylonitrile butadiene styrene and polylactic acid carrier-beads for Gluconobacter oxydans immobilization
Given the impending scarcity, rising costs, and environmental impact of fossil fuels, there is growing interest in utilizi...
Untargeted metabolomics profiling reveals carbon source-dependent rhamnolipid congener production in Burkholderia thailandensis E264
Rhamnolipid (RL) is a glycolipid biosurfactant containing rhamnose and β-hydroxylated fatty acid chains with diverse struc...
Conventional to bacteria-based cancer therapy through bacterial components and drug delivery approaches: Pre-clinical, clinical, and future progression
One of the most feared and common causes of mortality in the world is cancer, which has had a serious impact on people and...
Characterisation of chikungunya virus neutralising monoclonal antibodies expressed in tobacco plants
Chikungunya virus (CHIKV) causes a debilitating musculoskeletal disease, characterised by flu-like symptoms, rash, and sev...
Microwave-assisted biogenic synthesis of pure copper oxide nanoparticles by Lepidium sativum L. leaves extract: Characterization and evaluation of antibacterial activity
Nanotechnology is swiftly becoming a revolutionary scientific discipline focused on the synthesis, characterization, and d...
Novel polygalacturonase PG-BG31 prevents biofilm formation and increases antibiotic efficacy against catheter-associated Escherichia coli
Escherichia coli is a Gram-negative, facultatively anaerobic bacterium commonly found in the gut of humans and animals, wh...
Application of a novel virus-like particle platform to the development of Neisseria vaccines
Development of vaccines against meningococcal meningitis has been driven by the identification of protective protein antig...
Acid-triggered ultralong hydrogen release from AB-loaded hollow mesoporous silica nanoparticles enhances salt tolerance in sweetpotato
Soil salinization is a critical challenge for worldwide agriculture, impairing crop growth and reducing yields while hinde...
Efficient production of spermidine from Bacillus amyloliquefaciens by enhancing synthesis pathway, blocking degradation pathway and increasing precursor supply
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Mechanism of rhamnolipid promoting the degradation of polycyclic aromatic hydrocarbons by gram-positive bacteria—Enhance transmembrane transport and electron transfer
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Markerless deletion of the putative type I and III restriction-modification systems in the cellulolytic bacterium Clostridium cellulovorans using a codBA-based counterselection technique
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Engineering Saccharomyces cerevisiae for continuous secretory production of hEGF in biofilm
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Digital holographic microscopy is suitable for lipid accumulation analysis in single cells of Yarrowia lipolytica
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Comparative analysis of substrate- and regio-selectivity of HpaB monooxygenases and their application to hydroxydaidzein synthesis
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A pump-free microfluidic co-culture system for investigating NK cell-tumor spheroid interactions in flow conditions
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Engineering Saccharomyces boulardii for cell surface display of heterologous protein
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Development of an advanced acetaldehyde detection solution based on yeast and bacterial surface display technology
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Efficient production of RNA in Saccharomyces cerevisiae through inducing high level transcription of functional ncRNA-SRG1
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